FUS ALS neurons activate major stress pathways and reduce translation as an early protective mechanism against neurodegeneration

댓글 달기 / BioGems, CHIR 99021, Small Molecules, Stem cell research, WNT pathway / 글쓴이

#CHIR 99021; #Dibutyryl-cAMP; #2520691;  #1698950 Cell Rep. 2023 Jan 24;42(2):112025. doi: 10.1016/j.celrep.2023.112025. Barbara Szewczyk 1, René Günther 2, Julia Japtok 3, Moritz J Frech 1, Marcel Naumann 1, Hyun O Lee 4, Andreas Hermann 5 Affiliations expand Free article Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder causing progressive loss of motor neurons. Mutations in Fused in sarcoma (FUS) leading to its cytoplasmic mislocalization cause a subset of …

FUS ALS neurons activate major stress pathways and reduce translation as an early protective mechanism against neurodegeneration 더 보기 »

Epiblast-like stem cells established by Wnt/β-catenin signaling manifest distinct features of formative pluripotency and germline competence

댓글 달기 / BioGems, CHIR 99021, Small Molecules, Stem cell research, WNT pathway / 글쓴이

# CHIR 99021; # PD0325901; # PD173074 ; # 2520691; # 3911091;  # 2191178 Cell Rep. 2023 Jan 31;42(1):112021. doi: 10.1016/j.celrep.2023.112021. Qing Luo 1, Han-Pin Pui 2, Jiayu Chen 3, Leqian Yu 4, Paulo R Jannig 1, Yu Pei 5, Linxuan Zhao 6, Xingqi Chen 6, Sophie Petropoulos 7, Jorge L Ruas 1, Jun Wu 8, Qiaolin Deng 9 Affiliations expand Free PMC article Abstract Different formative pluripotent stem cells harboring similar functional properties have been recently established to be lineage …

Epiblast-like stem cells established by Wnt/β-catenin signaling manifest distinct features of formative pluripotency and germline competence 더 보기 »

Network-informed discovery of multidrug combinations for ERα+/HER2-/PI3Kα-mutant breast cancer

댓글 달기 / BioGems, ROCK inhibitor, Small Molecules, Stem cell research, Y-27632 / 글쓴이

#Y-27632;  #SB 202190; #1293823;  #1523072 Cell Mol Life Sci. 2023 Mar 3;80(3):80. doi: 10.1007/s00018-023-04730-x. Dina Hany 1 2, Marloes Zoetemelk 3 4 5, Kaushik Bhattacharya 1, Patrycja Nowak-Sliwinska 3 4 5, Didier Picard 6 Affiliations expand Free PMC article Abstract Breast cancer is a persistent threat to women worldwide. A large proportion of breast cancers are dependent on the estrogen receptor α (ERα) for tumor progression. Therefore, targeting ERα with …

Network-informed discovery of multidrug combinations for ERα+/HER2-/PI3Kα-mutant breast cancer 더 보기 »

The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor

댓글 달기 / BioGems, Small Molecules, Stem cell research / 글쓴이

#SB 431542 ;  #dorsomorphin;  #3014193 ;  #8666430 Front Mol Neurosci. 2023 Apr 6;16:1154509. doi: 10.3389/fnmol.2023.1154509 Debbra Y Knorr 1, Ignacio Rodriguez Polo 2 3 4 5, Hanna S Pies 1, Nicola Schwedhelm-Domeyer 1, Stephanie Pauls 1, Rüdiger Behr 3 4, Ralf Heinrich 1 Affiliations expand Free PMC article Abstract The evolutionary conserved orphan cytokine receptor-like factor 3 (CRLF3) has been implicated in human disease, vertebrate hematopoiesis and insect neuroprotection. While its specific functions …

The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor 더 보기 »

Matrigel-based organoid culture of malignant mesothelioma reproduces cisplatin sensitivity through CTR1

댓글 달기 / BioGems, Small Molecules, Stem cell research / 글쓴이

#A 83-01; #9094360 BMC Cancer. 2023 May 31;23(1):487. doi: 10.1186/s12885-023-10966-4. Fumiya Ito # 1, Katsuhiro Kato # 2, Izumi Yanatori 3, Yuki Maeda 1, Toyoaki Murohara 2, Shinya Toyokuni 4 5 Affiliations expand Free PMC article Abstract Organoids are a three-dimensional (3D) culture system that simulate actual organs. Therefore, tumor organoids are expected to predict precise response to chemotherapy in patients. However, to date, few studies have studied the drug …

Matrigel-based organoid culture of malignant mesothelioma reproduces cisplatin sensitivity through CTR1 더 보기 »

A method for differentiating human induced pluripotent stem cells toward functional cardiomyocytes in 96-well microplates.

댓글 달기 / BioGems, extracellular matrix and substrate, Organoid, Stem cell research / 글쓴이

#BG iMatrix-511, #RL511 Sci Rep . 2020 Oct 28;10(1):18498. doi: 10.1038/s41598-020-73656-2. Novin Balafkan 1, Sepideh Mostafavi 1, Manja Schubert 2, Richard Siller 3 4, Kristina Xiao Liang 2, Gareth Sullivan 5 3 4 6, Laurence A Bindoff 7 8 9 Abstract The capacity of pluripotent stem cells both for self-renewal and to differentiate into any cell type have made them a powerful tool for studying human disease. Protocols for efficient differentiation towards cardiomyocytes using …

A method for differentiating human induced pluripotent stem cells toward functional cardiomyocytes in 96-well microplates. 더 보기 »

2023년 상반기 BioGems 제품 인용 논문 리스트 (23.5월 현재)

댓글 달기 / BioGems, Buffers and Solutions, CHIR 99021, Flow cytometry, Organoid, ROCK inhibitor, Small Molecules, Stem cell research, viability dye 780, WNT pathway, Y-27632 / 글쓴이

Impact Factor Journal Name / Citation Product SKK or Cat# Title 　 Pubmed or other links 5월 신규 38.12 Signal Transduct Target Ther. 2023 May 19;8(1):187. doi: 10.1038/s41392-023-01405-8 Gastrin I ; A83-01 1003377;  9094360 FBXW7β loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth https://pubmed.ncbi.nlm.nih.gov/37202390/ 5월 신규 8.755 Cell Prolif. 2023 May;56(5):e13472. doi: 10.1111/cpr.13472. Anti-mouse …

2023년 상반기 BioGems 제품 인용 논문 리스트 (23.5월 현재) 더 보기 »

2023년 BioGems 제품 인용 논문 리스트

댓글 달기 / BioGems, Buffers and Solutions, CHIR 99021, ELISA Kit, extracellular matrix and substrate, Flow cytometry, Media supplements, Organoid, ROCK inhibitor, Small Molecules, Stem cell research, viability dye 780, WNT pathway, Y-27632 / 글쓴이

2023년 12월 말 기준 BioGems 제품 인용 최신 논문 리스트 입니다. (총 145편). No Pub. Date Impact Factor Journal Name / Citation Title Product SKK or Cat# Pubmed or other links Note 146 12월 신규 32.09 Adv Mater. 2023 Dec;35(51):e2304654. doi: 10.1002/adma.202304654. Brain-Targeted Liposomes Loaded with Monoclonal Antibodies Reduce Alpha-Synuclein Aggregation and Improve Behavioral Symptoms …

2023년 BioGems 제품 인용 논문 리스트 더 보기 »

Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models

댓글 달기 / Small Molecules, Stem cell research / 글쓴이

#SU5402 (Biogems, 2159233) Nat Commun. 2022 Nov 17;13(1):7032. doi: 10.1038/s41467-022-34811-7. Hsueh-Fu Wu 1 2, Wenxin Yu 3, Kenyi Saito-Diaz 1, Chia-Wei Huang 2 4, Joseph Carey 5, Frances Lefcort 5, Gerald W Hart 2 4, Hong-Xiang Liu 3, Nadja Zeltner 6 7 8 Affiliations expand Free PMC article Abstract Familial dysautonomia (FD), a rare neurodevelopmental and neurodegenerative disorder affects the sympathetic and sensory nervous system. Although almost all patients harbor a mutation in ELP1, it remains unresolved exactly …

Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models 더 보기 »

Large-Scale Production of Wholly Cellular Bioinks via the Optimization of Human Induced Pluripotent Stem Cell Aggregate Culture in Automated Bioreactors

댓글 달기 / Small Molecules, Stem cell research / 글쓴이

# Y-27632 dihydrochloride (BioGems 21293823) #SB431542 (Biogems 3014193) #LDN193189 (Biogems 1066208) #CHIR99021 (BioGems 2520691) #iWR1 (BioGems 1128234) Adv Healthc Mater. 2022 Oct 31;e2201138 Debbie L L Ho 1, Stacey Lee 1, Jianyi Du 1, Jonathan D Weiss 1, Tony Tam 1, Soham Sinha 1, Danielle Klinger 1, Sean Devine 2, Art Hamfeldt 2, Hope T Leng 1, Jessica E Herrmann 1 3, Mengdi He 4, Lee G Fradkin 1, Tze Kai Tan 5 6 7, David Standish 2, Peter Tomasello 2, Donald Traul 2, Noushin Dianat 8, Rukmini Ladi 2, Quentin Vicard 8, Kishore Katikireddy 2, Mark A Skylar-Scott 1 9 10 Abstract …

Large-Scale Production of Wholly Cellular Bioinks via the Optimization of Human Induced Pluripotent Stem Cell Aggregate Culture in Automated Bioreactors 더 보기 »

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