TGFβ promotes YAP-dependent AXL induction in mesenchymal-type lung cancer cells

https://pubmed.ncbi.nlm.nih.gov/33207077/ Mol Oncol. 2021 Feb;15(2):679-696. doi: 10.1002/1878-0261.12857. Epub 2020 Dec 5. Jeong-Yun Choi 1, Haeseung Lee 2, Eun-Ji Kwon 1, Hyeon-Joon Kong 1, Ok-Seon Kwon 3, Hyuk-Jin Cha 1 4Affiliations expand PMID: 33207077 PMCID: PMC7858114 DOI: 10.1002/1878-0261.12857 Abstract The acquisition of chemoresistance remains a major cause of cancer mortality due to the limited accessibility of targeted or immune therapies. However, given that severe alterations of molecular features during epithelial-to-mesenchymal transition (EMT) …

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Rapid and Simplified Induction of Neural Stem/Progenitor Cells (NSCs/NPCs) and Neurons from Human Induced Pluripotent Stem Cells (hiPSCs)

https://pubmed.ncbi.nlm.nih.gov/33732801/ Bio Protoc. 2021 Feb 5;11(3):e3914. doi: 10.21769/BioProtoc.3914. Ryutaro Kajihara 1 2 3, Tadahiro Numakawa 1, Takumi Era 1Affiliations expand PMID: 33732801 PMCID: PMC7952933 DOI: 10.21769/BioProtoc.3914 Abstract Human induced pluripotent stem cells (iPSCs) and their progeny displaying tissue-specific characteristics have paved the way for regenerative medicine and research in various fields such as the elucidation of the pathological mechanism of diseases and the discovery of drug …

Rapid and Simplified Induction of Neural Stem/Progenitor Cells (NSCs/NPCs) and Neurons from Human Induced Pluripotent Stem Cells (hiPSCs) 더 보기 »

Discovery of a Novel Long Noncoding RNA Lx8-SINE B2 as a Marker of Pluripotency

https://pubmed.ncbi.nlm.nih.gov/33628268/ Stem Cells Int. 2021 Feb 6;2021:6657597. doi: 10.1155/2021/6657597. eCollection 2021. Fuquan Chen 1, Miao Zhang 1, Xiao Feng 1, Xiaomin Li 1, Haotian Sun 1, Xinyi Lu 1 PMID: 33628268 PMCID: PMC7884122 DOI: 10.1155/2021/6657597 Abstract Pluripotency and self-renewal of embryonic stem cells (ESCs) are marked by core transcription regulators such as Oct4, Sox2, and Nanog. Another important marker of pluripotency is the long noncoding RNA (lncRNA). Here, we …

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