Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy

댓글 달기 / BioGems, CHIR 99021, Small Molecules, Stem cell research, WNT pathway / 글쓴이

#CHIR 99021 ; #2520691 ; J Clin Invest. 2023 Aug 10;e171356. doi: 10.1172/JCI171356. Meha Kabra 1 2, Pawan K Shahi 1 2, Yuyuan Wang 3 4, Divya Sinha 2 5, Allison Spillane 1, Gregory A Newby 6 7 8, Shivani Saxena 2 3 4, Yao Tong 3 4, Yu Chang 1, Amr A Abdeen 2 3 4, Kimberly L Edwards 2 5, Cole O Theisen 5, David R Liu 6 7 8, David M Gamm 2 5 9, Shaoqin Gong 2 3 4 9, Krishanu Saha 1 2 3 4 10, Bikash R Pattnaik 1 2 9 Affiliations expand Free PMC article Abstract Clinical genome editing is emerging for rare disease treatment, but one …

Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy 더 보기 »

Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy

댓글 달기 / BioGems, CHIR 99021, Small Molecules, WNT pathway / 글쓴이

#CHIR 99021 ; #2520691 ; J Clin Invest. 2023 Aug 10;e171356. doi: 10.1172/JCI171356. Meha Kabra 1, Pawan K Shahi 1, Yuyuan Wang 2, Divya Sinha 3, Allison Spillane 1, Gregory A Newby 4, Shivani Saxena 3, Yao Tong 2, Yu Chang 1, Amr A Abdeen 2, Kimberly L Edwards 3, Cole O Theisen 3, David R Liu 4, David M Gamm 3, Shaoqin Gong 2, Krishanu Saha 2, Bikash R Pattnaik 1 Affiliations expand Free article Abstract Clinical genome editing is emerging for rare disease treatment, but one of …

Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy 더 보기 »

A critical role for heme synthesis and succinate in the regulation of pluripotent states transitions

댓글 달기 / BioGems, CHIR 99021, Small Molecules, WNT pathway / 글쓴이

#CHIR 99021 ; #2520691 ; Elife. 2023 Jul 10;12:e78546. doi: 10.7554/eLife.78546. Damien Detraux 1 2, Marino Caruso 1, Louise Feller 1, Maude Fransolet 1, Sébastien Meurant 1, Julie Mathieu 2 3, Thierry Arnould 1, Patricia Renard 1 Affiliations expand Free PMC article Abstract Using embryonic stem cells (ESCs) in regenerative medicine or in disease modeling requires a complete understanding of these cells. Two main distinct developmental states of ESCs have been stabilized in …

A critical role for heme synthesis and succinate in the regulation of pluripotent states transitions 더 보기 »

Human iPS cell-derived sensory neurons can be infected by SARS-CoV-2

댓글 달기 / BioGems, CHIR 99021, Small Molecules, WNT pathway / 글쓴이

#CHIR 99021 ; #2520691 ; iScience 26, 107690, September 15, 2023 Anthony Flamier 1, Punam Bisht 1, Alexsia Richards 1, Danielle L Tomasello 1, Rudolf Jaenisch 1 2 Affiliations expand Free PMC article Abstract COVID-19 has impacted billions of people since 2019 and unfolded a major healthcare crisis. With an increasing number of deaths and the emergence of more transmissible variants, it is crucial to better …

Human iPS cell-derived sensory neurons can be infected by SARS-CoV-2 더 보기 »

Maintenance of adult stem cells from human minor salivary glands via the Wnt signaling pathway

댓글 달기 / BioGems, CHIR 99021, Small Molecules, WNT pathway / 글쓴이

#CHIR 99021 ; #2520691 Stem Cell Res Ther 14, 220 (2023). https://doi.org/10.1186/s13287-023-03445-x Bo Kyoung Kang # 1 2, Zhu Zhu # 1 2, Jian Wang 1, Jia Zhou 1, Shun Yu 3, Xianyu Zhou 1, Zhenmin Zhao 4, Aiguo Xie 5, Lin Lu 6, Jun Yang 7 Affiliations expand Free PMC article Abstract Background: Xerostomia is a salivary gland dysfunction that negatively impacts the life quality of patients; however, there is no effective treatment for xerostomia. Bioengineered organs, generated using …

Maintenance of adult stem cells from human minor salivary glands via the Wnt signaling pathway 더 보기 »

Corrosion Products from Metallic Implants Induce ROS and Cell Death in Human Motoneurons In Vitro

댓글 달기 / BioGems, CHIR 99021, Small Molecules, WNT pathway / 글쓴이

#CHIR 99021; #Dibutyryl-cAMP ; #2520691;  #1698950 J. Funct. Biomater. 2023, 14(8), 392; https://doi.org/10.3390/jfb14080392 Hannes Glaß 1, Anika Jonitz-Heincke 2, Janine Petters 1, Jan Lukas 1 3, Rainer Bader 2, Andreas Hermann 1 3 4 Affiliations expand Free PMC article Abstract Due to advances in surgical procedures and the biocompatibility of materials used in total joint replacement, more and younger patients are undergoing these procedures. Although state-of-the-art joint replacements can last …

Corrosion Products from Metallic Implants Induce ROS and Cell Death in Human Motoneurons In Vitro 더 보기 »

FUS ALS neurons activate major stress pathways and reduce translation as an early protective mechanism against neurodegeneration

댓글 달기 / BioGems, CHIR 99021, Small Molecules, Stem cell research, WNT pathway / 글쓴이

#CHIR 99021; #Dibutyryl-cAMP; #2520691;  #1698950 Cell Rep. 2023 Jan 24;42(2):112025. doi: 10.1016/j.celrep.2023.112025. Barbara Szewczyk 1, René Günther 2, Julia Japtok 3, Moritz J Frech 1, Marcel Naumann 1, Hyun O Lee 4, Andreas Hermann 5 Affiliations expand Free article Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder causing progressive loss of motor neurons. Mutations in Fused in sarcoma (FUS) leading to its cytoplasmic mislocalization cause a subset of …

FUS ALS neurons activate major stress pathways and reduce translation as an early protective mechanism against neurodegeneration 더 보기 »

Epiblast-like stem cells established by Wnt/β-catenin signaling manifest distinct features of formative pluripotency and germline competence

댓글 달기 / BioGems, CHIR 99021, Small Molecules, Stem cell research, WNT pathway / 글쓴이

# CHIR 99021; # PD0325901; # PD173074 ; # 2520691; # 3911091;  # 2191178 Cell Rep. 2023 Jan 31;42(1):112021. doi: 10.1016/j.celrep.2023.112021. Qing Luo 1, Han-Pin Pui 2, Jiayu Chen 3, Leqian Yu 4, Paulo R Jannig 1, Yu Pei 5, Linxuan Zhao 6, Xingqi Chen 6, Sophie Petropoulos 7, Jorge L Ruas 1, Jun Wu 8, Qiaolin Deng 9 Affiliations expand Free PMC article Abstract Different formative pluripotent stem cells harboring similar functional properties have been recently established to be lineage …

Epiblast-like stem cells established by Wnt/β-catenin signaling manifest distinct features of formative pluripotency and germline competence 더 보기 »

Diminished motor neuron activity driven by abnormal astrocytic EAAT1 glutamate transporter activity in spinal muscular atrophy is not fully restored after lentiviral SMN delivery.

댓글 달기 / BioGems, CHIR 99021, ROCK inhibitor, Small Molecules, WNT pathway, Y-27632 / 글쓴이

#SB 431542; LDN 193189; CHIR 99021; DAPT,  #3014193; 1066208; 2520691; 2088055 Glia. 2023 May;71(5):1311-1332. doi: 10.1002/glia.24340. Emily Welby 1, Allison D Ebert  Abstract Spinal muscular atrophy (SMA) is characterized by the loss of the lower spinal motor neurons due to survival motor neuron (SMN) deficiency. The motor neuron cell autonomous and non-cell autonomous disease mechanisms driving early …

Diminished motor neuron activity driven by abnormal astrocytic EAAT1 glutamate transporter activity in spinal muscular atrophy is not fully restored after lentiviral SMN delivery. 더 보기 »

ORGAVADS: establishment of tumor organoids from head and neck squamous cell carcinoma to assess their response to innovative therapies.

댓글 달기 / BioGems, CHIR 99021, Small Molecules, WNT pathway / 글쓴이

#CHIR 99021; # 2520691 BMC Cancer . 2023 Mar 9;23(1):223. doi: 10.1186/s12885-023-10692-x. Marion Perréard 1 2 3, Romane Florent 1 2 4, Jordane Divoux 1 2 4, Jean-Michel Grellard 2 5, Justine Lequesne 2 5, Mélanie Briand 1 2 6, Bénédicte Clarisse 2 5, Nathalie Rousseau 2 7, Esther Lebreton 8, Brice Dubois 2 9, Valentin Harter 2 9, Audrey Lasne-Cardon 2 10, Julien Drouet 2 11, Alisson Johnson 2 12, Anne-Laure Le Page 13, Céline Bazille 13, Corinne Jeanne 2 14, Martin Figeac 15, Nicolas Goardon 2 16, Dominique Vaur 2 16, Emmanuel Micault 3, Maxime Humbert 3, Juliette Thariat 2 17, Emmanuel Babin 1 3, Laurent Poulain 1 2 4, Louis-Bastien Weiswald # 18 19 20, Vianney Bastit # 21 22 Abstract Background: Radiotherapy is one of the cornerstones of the treatment of Head and Neck …

ORGAVADS: establishment of tumor organoids from head and neck squamous cell carcinoma to assess their response to innovative therapies. 더 보기 »

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