A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation

댓글 달기 / ROCK inhibitor, Small Molecules, Y-27632 / 글쓴이

https://pubmed.ncbi.nlm.nih.gov/33451982/ Cancer Discov. 2021 Jun;11(6):1562-1581. doi: 10.1158/2159-8290.CD-20-1109. Epub 2021 Jan 15. Yuan-Hung Lo 1, Kevin S Kolahi 2, Yuhong Du 3, Chiung-Ying Chang 2, Andrey Krokhotin 4, Ajay Nair 5, Walter D Sobba 1, Kasper Karlsson 1 6, Sunny J Jones 5, Teri A Longacre 2, Amanda T Mah 1, Bahar Tercan 7, Alexandra Sockell 6, Hang Xu 6, Jose A Seoane 6, Jin Chen 8 9, Ilya Shmulevich 7, Jonathan S Weissman 8, Christina Curtis 6, Andrea Califano 5, Haian Fu 3, Gerald R Crabtree 2 4 10, Calvin J Kuo 11Affiliations expand PMID: 33451982 PMCID: PMC8346515 DOI: 10.1158/2159-8290.CD-20-1109 Abstract Mutations in ARID1A rank among the most common molecular …

A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation 더 보기 »

Induction of alveolar and bronchiolar phenotypes in human lung organoids

댓글 달기 / CHIR 99021, ROCK inhibitor, Small Molecules, WNT pathway, Y-27632 / 글쓴이

Physiol Rep. 2021 Jun;9(11):e14857. doi: 10.14814/phy2.14857. Laurence Hoareau 1 2, Agnete S T Engelsen 3 4, Marianne Aanerud 1 5, Maria Paula Ramnefjell 4 6, Pirjo-Riitta Salminen 7, Fabian Gärtner 5, Thomas Halvorsen 1 2, Helge Raeder 1 2, Mariann H L Bentsen 1 2 PMID: 34110705 PMCID: PMC8191394 DOI: 10.14814/phy2.14857 Abstract Patient-derived organoids have revolutionized biomedical research and therapies by “transferring the patient into the Petri dish”. In vitro access to human lung organoids representing distal lung tissue, i.e. alveolar organoids, …

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SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients

댓글 달기 / Small Molecules, Stem cell research, WNT pathway / 글쓴이

Elife. 2021 Jun 8;10:e67481. doi: 10.7554/eLife.67481. Fei Liang # 1 2, Bo Wang # 3, Juan Geng 3, Guoling You 3, Jingjing Fa 3, Min Zhang 2, Hunying Sun 4, Huiwen Chen 5, Qihua Fu 3, Xiaoqing Zhang 3, Zhen Zhang 2 PMID: 34099102 원본링크: https://pubmed.ncbi.nlm.nih.gov/34099102/ PMCID: PMC8186900 DOI: 10.7554/eLife.67481 Abstract Chromosome 4q deletion is one of the most frequently detected genomic imbalance events in congenital heart disease (CHD) patients. However, a portion of CHD-associated 4q deletions without known CHD genes suggests …

SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients 더 보기 »

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