Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channels
https://pubmed.ncbi.nlm.nih.gov/31523707/ Sci Adv. 2019 Sep 6;5(9):eaaw2459. doi: 10.1126/sciadv.aaw2459. eCollection 2019 Sep. Mark A Skylar-Scott 1 2, Sebastien G M Uzel 1 2, Lucy L Nam 1 2, John H Ahrens 1 2, Ryan L Truby 1 2, Sarita Damaraju 1 2, Jennifer A Lewis 1 2 PMID: 31523707 PMCID: PMC6731072 DOI: 10.1126/sciadv.aaw2459 AbstractEngineering organ-specific tissues for therapeutic applications is a grand challenge, requiring the fabrication and maintenance of densely cellular constructs composed of ~108 cells/ml. Organ building blocks …