Abnormal developmental trajectory and vulnerability to cardiac arrhythmias in tetralogy of Fallot with DiGeorge syndrome

댓글 달기 / BioGems, ROCK inhibitor, Small Molecules, Stem cell research, Y-27632 / 글쓴이

#Y-27632 ; #1293823 ; Cells 2023, 12(18), 2319; https://doi.org/10.3390/cells12182319 Chun-Ho Chan 1, Yin-Yu Lam 1, Nicodemus Wong 1, Lin Geng 1, Jilin Zhang 2, Virpi Ahola 2, Aman Zare 2, Ronald Adolphus Li 2 3, Fredrik Lanner 4 5 6, Wendy Keung 3, Yiu-Fai Cheung 7 8 9 Affiliations expand Abstract Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. Ventricular dysfunction and cardiac arrhythmias are well-documented complications in patients with repaired TOF. Whether intrinsic abnormalities exist in TOF …

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Modeling of FAN1-Deficient Kidney Disease Using a Human Induced Pluripotent Stem Cell-Derived Kidney Organoid System

댓글 달기 / BioGems, ROCK inhibitor, Small Molecules, Stem cell research, Y-27632 / 글쓴이

#Y-27632 ; #1293823 ; Commun Biol. 2023 Sep 22;6(1):969. doi: 10.1038/s42003-023-05344-6. Sun Woo Lim, Dohyun Na, Hanbi Lee, Xianying Fang, Sheng Cui, Yoo Jin Shin, Kang In Lee, Jae Young Lee, Chul Woo Yang and Byung Ha Chung Abstract Karyomegalic interstitial nephritis (KIN) is a genetic kidney disease caused by mutations in the FANCD2/FANCI-Associated Nuclease …

Modeling of FAN1-Deficient Kidney Disease Using a Human Induced Pluripotent Stem Cell-Derived Kidney Organoid System 더 보기 »

Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy

댓글 달기 / BioGems, CHIR 99021, Small Molecules, WNT pathway / 글쓴이

#CHIR 99021 ; #2520691 ; J Clin Invest. 2023 Aug 10;e171356. doi: 10.1172/JCI171356. Meha Kabra 1, Pawan K Shahi 1, Yuyuan Wang 2, Divya Sinha 3, Allison Spillane 1, Gregory A Newby 4, Shivani Saxena 3, Yao Tong 2, Yu Chang 1, Amr A Abdeen 2, Kimberly L Edwards 3, Cole O Theisen 3, David R Liu 4, David M Gamm 3, Shaoqin Gong 2, Krishanu Saha 2, Bikash R Pattnaik 1 Affiliations expand Free article Abstract Clinical genome editing is emerging for rare disease treatment, but one of …

Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy 더 보기 »

Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk

댓글 달기 / BioGems, Small Molecules / 글쓴이

#A 83-01 ;  #9094360 ; Med. 2023 Aug 11;4(8):554-579.e9. doi: 10.1016/j.medj.2023.07.004. Juan S Gnecco 1, Alexander Brown 2, Kira Buttrey 3, Clara Ives 2, Brittany A Goods 4, Lauren Baugh 2, Victor Hernandez-Gordillo 3, Megan Loring 5, Keith B Isaacson 5, Linda G Griffith 6 Affiliations expand Abstract Background: The human endometrium undergoes recurring cycles of growth, differentiation, and breakdown in response to sex hormones. Dysregulation of epithelial-stromal communication during hormone-mediated signaling may be linked to …

Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk 더 보기 »

Single-cell transcriptomic analysis uncovers the origin and intratumoral heterogeneity of parotid pleomorphic adenoma

댓글 달기 / BioGems, Small Molecules / 글쓴이

#A 83-01 ;  #9094360 ; Int J Oral Sci. 2023 Sep 7;15(1):38. doi: 10.1038/s41368-023-00243-2. Xiuyun Xu # 1 2 3, Jiaxiang Xie # 1 2 3, Rongsong Ling 4, Shengqi Ouyang 1 2 3, Gan Xiong 1 2 3, Yanwen Lu 1 2 3, Bokai Yun 1 2 3, Ming Zhang 1 2 3, Wenjin Wang 1 2 3, Xiqiang Liu 5, Demeng Chen 6, Cheng Wang 7 8 9 Affiliations expand Free PMC article Abstract Pleomorphic adenoma (PA) is the most common benign tumour in the salivary gland and has high morphological complexity. However, the origin and intratumoral …

Single-cell transcriptomic analysis uncovers the origin and intratumoral heterogeneity of parotid pleomorphic adenoma 더 보기 »

A critical role for heme synthesis and succinate in the regulation of pluripotent states transitions

댓글 달기 / BioGems, CHIR 99021, Small Molecules, WNT pathway / 글쓴이

#CHIR 99021 ; #2520691 ; Elife. 2023 Jul 10;12:e78546. doi: 10.7554/eLife.78546. Damien Detraux 1 2, Marino Caruso 1, Louise Feller 1, Maude Fransolet 1, Sébastien Meurant 1, Julie Mathieu 2 3, Thierry Arnould 1, Patricia Renard 1 Affiliations expand Free PMC article Abstract Using embryonic stem cells (ESCs) in regenerative medicine or in disease modeling requires a complete understanding of these cells. Two main distinct developmental states of ESCs have been stabilized in …

A critical role for heme synthesis and succinate in the regulation of pluripotent states transitions 더 보기 »

Human iPS cell-derived sensory neurons can be infected by SARS-CoV-2

댓글 달기 / BioGems, CHIR 99021, Small Molecules, WNT pathway / 글쓴이

#CHIR 99021 ; #2520691 ; iScience 26, 107690, September 15, 2023 Anthony Flamier 1, Punam Bisht 1, Alexsia Richards 1, Danielle L Tomasello 1, Rudolf Jaenisch 1 2 Affiliations expand Free PMC article Abstract COVID-19 has impacted billions of people since 2019 and unfolded a major healthcare crisis. With an increasing number of deaths and the emergence of more transmissible variants, it is crucial to better …

Human iPS cell-derived sensory neurons can be infected by SARS-CoV-2 더 보기 »

Glioma Stem Cells Are Sensitized to BCL-2 Family Inhibition by Compromising Histone Deacetylases

댓글 달기 / BioGems, Small Molecules / 글쓴이

# Propidium iodide ; # 60910-00 ;  Int. J. Mol. Sci. 2023, 24(18), 13688; https://doi.org/10.3390/ijms241813688 Aran Merati 1,Spandana Kotian 1,Alexus Acton 1,William Placzek 1ORCID,Erin Smithberger 2,3,Abigail K. Shelton 2,3,C. Ryan Miller 2,3ORCID andJosh L. Stern 1,2,*1Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA2O’Neal Comprehensive Cancer Center, Birmingham, AL 35294, …

Glioma Stem Cells Are Sensitized to BCL-2 Family Inhibition by Compromising Histone Deacetylases 더 보기 »

The immune and metabolic treatment approach of using testosterone on mice models of liver injury

댓글 달기 / BioGems, Flow cytometry / 글쓴이

# Anti-mouse NK1.1 ; #83712–70 Front Pharmacol. 2023 Aug 8;14:1219709. doi: 10.3389/fphar.2023.1219709. Johnny Amer 1, Ahmad Salhab 2, Hadeel Snobar 3, Yazan Alhabil 4 Affiliations expand Free PMC article Abstract Background: Natural killer (NK) cells showed an anti-fibrotic effect; however, their function is thought to be impaired in advanced liver injury. In the current study, we aimed to assess the immune and metabolic impact of …

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UCHL1 alleviates apoptosis in chondrocytes via upregulation of HIF‑1α‑mediated mitophagy

댓글 달기 / BioGems, Buffers and Solutions / 글쓴이

#Annexin V Apoptosis Detection Kit ;  #62700 ;  Int J Mol Med. 2023 Oct;52(4):99. doi: 10.3892/ijmm.2023.5302 Qiqian Yan 1, Shanwei Shi 1, Yang Ge 1, Shuangquan Wan 1, Mingfei Li 1, Maoquan Li 1 Affiliations expand Abstract Stem cell‑based tissue engineering has shown significant potential for rapid restoration of injured cartilage tissues. Stem cells frequently undergo apoptosis because of the prevalence of oxidative stress and inflammation in …

UCHL1 alleviates apoptosis in chondrocytes via upregulation of HIF‑1α‑mediated mitophagy 더 보기 »

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