The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor

댓글 달기 / BioGems, Small Molecules, Stem cell research / 글쓴이

#SB431542 ; #dorsomorphin ; #cAMP ;  #3014193 ; #8666430 ; #6099240 ;  Debbra Y Knorr 1, Ignacio Rodriguez Polo 2 3 4 5, Hanna S Pies 1, Nicola Schwedhelm-Domeyer 1, Stephanie Pauls 1, Rüdiger Behr 3 4, Ralf Heinrich 1 Affiliations expand Free PMC article Abstract The evolutionary conserved orphan cytokine receptor-like factor 3 (CRLF3) has been implicated in human disease, vertebrate hematopoiesis and insect neuroprotection. While its specific functions are elusive, experimental …

The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor 더 보기 »

Optogenetic induction of alpha-synuclein aggregation in human dopaminergic neurons to model Parkinson’s disease pathology

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#DAPT ; #2088055 ; Eun A Ra 1, Min Seong Kim 1, Gabsang Lee 2 Affiliations expand Free PMC article Abstract Alpha-synuclein (α-syn) aggregation is a principal factor in Parkinson’s disease (PD) onset. Here, we present a protocol for optogenetic induction of α-syn aggregation in human midbrain dopaminergic (mDA) neurons, facilitating a detailed PD pathology study. We describe steps for nucleofection …

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Protocol for capturing trophectoderm stem cells reflecting the blastocyst stage

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#1-oleoyl lysophosphatidic acid ; #2256236 ; Jinwoo Seong 1, Nicolas C Rivron 2 Affiliations expand Free PMC article Abstract Classically, culturing mouse blastocysts with FGF4/TGF-β1, two epiblast-secreted inducers, allows for deriving trophoblast stem cells that comprise fluctuating subpopulations reflecting both pre- and post-implantation stages. However, a more complete combination of inducers (adding LPA, IL11, BMP7, Activin A, 8-Br-cAMP) captures …

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Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis

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#Ionomycin ; #5608212 ; Xinyue Ma 1, Qiuman Wang 1, Chenggong Sun 1, Indu Agarwal 2, Huan Wu 1, Jingying Chen 1, Chen Zhao 1, Gonghua Qi 1, Qiuli Teng 1, Cunzhong Yuan 1, Shi Yan 1, Jiali Peng 1, Rongrong Li 1, Kun Song 1, Qing Zhang 3, Beihua Kong 4 Affiliations expand Free article Abstract Immune checkpoint blockade (ICB) therapies display clinical efficacy in microsatellite instable (MSI) endometrial cancer (EC) treatment, the key mechanism of which is reversing T cell exhaustion and restoration of anti-tumor …

Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis 더 보기 »

Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy

댓글 달기 / BioGems, CHIR 99021, Small Molecules, Stem cell research, WNT pathway / 글쓴이

#CHIR 99021 ; #2520691 ; J Clin Invest. 2023 Aug 10;e171356. doi: 10.1172/JCI171356. Meha Kabra 1 2, Pawan K Shahi 1 2, Yuyuan Wang 3 4, Divya Sinha 2 5, Allison Spillane 1, Gregory A Newby 6 7 8, Shivani Saxena 2 3 4, Yao Tong 3 4, Yu Chang 1, Amr A Abdeen 2 3 4, Kimberly L Edwards 2 5, Cole O Theisen 5, David R Liu 6 7 8, David M Gamm 2 5 9, Shaoqin Gong 2 3 4 9, Krishanu Saha 1 2 3 4 10, Bikash R Pattnaik 1 2 9 Affiliations expand Free PMC article Abstract Clinical genome editing is emerging for rare disease treatment, but one …

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3D-cultured blastoids model human embryogenesis from pre-implantation to early gastrulation stages

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#A 83-01 ;  #9094360 ; Cell Stem Cell. 2023 Sep 7;30(9):1148-1165.e7. doi: 10.1016/j.stem.2023.08.005. Rowan M Karvas 1, Joseph E Zemke 1, Syed Shahzaib Ali 2, Eric Upton 1, Eshan Sane 1, Laura A Fischer 1, Chen Dong 1, Kyoung-Mi Park 1, Fei Wang 3, Kibeom Park 3, Senyue Hao 3, Brian Chew 1, Brittany Meyer 1, Chao Zhou 3, Sabine Dietmann 4, Thorold W Theunissen 5 Abstract Naive human pluripotent stem cells have the remarkable ability to self-organize into blastocyst-like structures (“blastoids”) that model lineage segregation …

3D-cultured blastoids model human embryogenesis from pre-implantation to early gastrulation stages 더 보기 »

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