CIRP increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TLR4-IL-2 signaling in the late phase of sepsis
anti-IFN-γ (10 µg/ml; BioGems) BioGems ; Int Immunopharmacol. 2024 Mar 25:132:111924. doi: 10.1016/j.intimp.2024.111924. Zongsheng Wu 1, Xu Liu 1, Wei Huang 1, Jing Chen 1, Songli Li 1, Jie Chao 1, Jianfeng Xie 1, Ling Liu 1, Yi Yang 1, Xiaojing Wu 2, Haibo Qiu 3 Affiliations expand Abstract Background: T helper (Th) cell imbalances have been associated with the pathophysiology of sepsis, including the Th1/Th2 and Th17/T regulatory cells (Treg) paradigms. Cold-inducible RNA-binding protein (CIRP), a novel …