Analysis of organoid and immune cell co-cultures by machine learning-empowered image cytometry

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A 83-01 ; Y-27632 ; 9094360 ; 1293823 ; Front Med (Lausanne). 2024 Jan 17:10:1274482. doi: 10.3389/fmed.2023.1274482. eCollection 2023. Philipp Stüve # 1, Benedikt Nerb # 1 2, Selina Harrer 1, Marina Wuttke 1, Markus Feuerer 1 2, Henrik Junger 3, Elke Eggenhofer 3, Bianca Lungu 4, Simina Laslau 4, Uwe Ritter 1 2 Affiliations expand Abstract Organoids are three-dimensional (3D) structures that can be derived from stem cells or adult tissue progenitor cells and exhibit an extraordinary ability to …

Analysis of organoid and immune cell co-cultures by machine learning-empowered image cytometry 더 보기 »

Development of LAG-3/FGL1 blocking peptide and combination with radiotherapy for cancer immunotherapy

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human anti-CD3 (OKT3, Biogems) and human anti-CD28 (CD28.2, Biogems) BioGems ; Acta Pharm Sin B. 2024 Mar;14(3):1150-1165. doi: 10.1016/j.apsb.2023.12.011. Epub 2023 Dec 19. Yuzhen Qian 1, Yixuan Sun 2, Peishang Shi 1, Xiuman Zhou 2, Qiongqiong Zhang 1, Qingyu Dong 2, Shengzhe Jin 1, Lu Qiu 1 2, Xiaoshuang Niu 2, Xiaowen Zhou 1, Wenshan Zhao 1, Yahong Wu 1 3, Wenjie Zhai 1 3, Yanfeng Gao 1 2 Affiliations expand Abstract Aside from antibodies, peptides show great potential as immune checkpoint inhibitors (ICIs) due to several …

Development of LAG-3/FGL1 blocking peptide and combination with radiotherapy for cancer immunotherapy 더 보기 »

Fibroblasts facilitate lymphatic vessel formation in transplanted heart

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10X RBC Lysis Buffer ;  64010-00 ;  Theranostics. 2024; 14(5): 1886–1908. Published online 2024 Feb 24. doi: 10.7150/thno.92103 Hui Gong 1, Ting Wang 1, Xiaotong Sun 1, Yuesheng Zhang 1, Yichao Qiu 2, Wenlong Sun 3, Yue Zhang 3, Peng Teng 2, Yanhua Hu 1, Xiaosheng Hu 1, Liang Ma 2, Qingbo Xu 1, Haige Zhao 2 Affiliations expand Abstract Rationale: Lymphangiogenesis plays a critical role in the transplanted heart. The remodeling of lymphatics in the transplanted heart and the source of …

Fibroblasts facilitate lymphatic vessel formation in transplanted heart 더 보기 »

CIRP increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TLR4-IL-2 signaling in the late phase of sepsis

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 anti-IFN-γ (10 µg/ml; BioGems) BioGems ; Int Immunopharmacol. 2024 Mar 25:132:111924. doi: 10.1016/j.intimp.2024.111924. Zongsheng Wu 1, Xu Liu 1, Wei Huang 1, Jing Chen 1, Songli Li 1, Jie Chao 1, Jianfeng Xie 1, Ling Liu 1, Yi Yang 1, Xiaojing Wu 2, Haibo Qiu 3 Affiliations expand Abstract Background: T helper (Th) cell imbalances have been associated with the pathophysiology of sepsis, including the Th1/Th2 and Th17/T regulatory cells (Treg) paradigms. Cold-inducible RNA-binding protein (CIRP), a novel …

CIRP increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TLR4-IL-2 signaling in the late phase of sepsis 더 보기 »

Early host immune responses in a human organoid-derived gallbladder monolayer to Salmonella Typhi strains from patients with acute and chronic infections: a comparative analysis

댓글 달기 / BioGems, ROCK inhibitor, Small Molecules, Y-27632 / 글쓴이

Y-27632 ; 1293823 ; Front Immunol. 2024 Mar 12:15:1334762. doi: 10.3389/fimmu.2024.1334762. eCollection 2024 Rosângela Salerno-Goncalves 1, Haiyan Chen 1, Andrea C Bafford 2, Mariana Izquierdo 1, Juan Carlos Hormazábal 3, Rosanna Lagos 3, Hervé Tettelin 4, Adonis D’Mello 4, Jayaum S Booth 1, Alessio Fasano 5, Myron M Levine 1, Marcelo B Sztein 1 6 Affiliations expand Abstract Salmonella enterica serovar Typhi (S. Typhi), a human-restricted pathogen, invades the host through the gut to cause typhoid fever. Recent calculations of the …

Early host immune responses in a human organoid-derived gallbladder monolayer to Salmonella Typhi strains from patients with acute and chronic infections: a comparative analysis 더 보기 »

Discovery of a novel small molecule as CD47/SIRPα and PD-1/PD-L1 dual inhibitor for cancer immunotherapy

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anti-human CD3 (OKT3);  anti-human CD28 (CD28.2) ; BioGems ; Cell Commun Signal. 2024 Mar 11;22(1):173. doi: 10.1186/s12964-024-01555-4. Shengzhe Jin # 1, Hongfei Wang # 2, Yang Li # 1, Jingwen Yang 1, Beibei Li 1, Peishang Shi 1, Xiangrui Zhang 1, Xiaowen Zhou 1, Xiuman Zhou 3, Xiaoshuang Niu 3, Menghan Wu 1, Yahong Wu 1 4, Wenjie Zhai 1 4, Yuanming Qi 1, Yanfeng Gao 5, Wenshan Zhao 6 Affiliations expand Abstract Background: Targeting the tumor microenvironment (TME) has emerged as a promising strategy in cancer treatment, particularly through the utilization of …

Discovery of a novel small molecule as CD47/SIRPα and PD-1/PD-L1 dual inhibitor for cancer immunotherapy 더 보기 »

Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells

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LY294002 ; 1543664 ; Cell Rep Med. 2024 Jan 16;5(1):101377. doi: 10.1016/j.xcrm.2023.101377. Jenny Sprooten 1, Isaure Vanmeerbeek 1, Angeliki Datsi 2, Jannes Govaerts 1, Stefan Naulaerts 1, Raquel S Laureano 1, Daniel M Borràs 1, Anna Calvet 1, Vanshika Malviya 3, Marc Kuballa 2, Jörg Felsberg 4, Michael C Sabel 4, Marion Rapp 4, Christiane Knobbe-Thomsen 4, Peng Liu 5, Liwei Zhao 5, Oliver Kepp 5, Louis Boon 6, Sabine Tejpar 7, Jannie Borst 8, Guido Kroemer 9, Susan Schlenner 3, Steven De Vleeschouwer 10, Rüdiger V Sorg 2, Abhishek D Garg 11 Affiliations expand Abstract Current immunotherapies provide limited benefits against T cell-depleted tumors, …

Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells 더 보기 »

Structural basis for the modulation of MRP2 activity by phosphorylation and drugs

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Forskolin ; 6652995 ;  Nat Commun. 2024 Mar 4;15(1):1983. doi: 10.1038/s41467-024-46392-8. Tiziano Mazza 1 2 3, Theodoros I Roumeliotis # 4, Elena Garitta # 5, David Drew 6, S Tamir Rashid 7, Cesare Indiveri 3 8, Jyoti S Choudhary 4, Kenneth J Linton 5, Konstantinos Beis 9 10 Affiliations expand Abstract Multidrug resistance-associated protein 2 (MRP2/ABCC2) is a polyspecific efflux transporter of organic anions expressed in hepatocyte canalicular membranes. MRP2 dysfunction, in Dubin-Johnson syndrome or by off-target inhibition, for …

Structural basis for the modulation of MRP2 activity by phosphorylation and drugs 더 보기 »

ALOX5 drives the pyroptosis of CD4+ T cells and tissue inflammation in rheumatoid arthritis

댓글 달기 / BioGems, Flow cytometry / 글쓴이

Anti-Rat CD28 ; Anti-Rat CD3 ; 10313 ; 05113 ; Sci Signal. 2024 Feb 27;17(825):eadh1178. doi: 10.1126/scisignal.adh1178. Epub 2024 Feb 27. Hao Cai 1, Jianhua Zhang 1, Hua Xu 1, Weiwei Sun 1, Weijie Wu 1, Chen Dong 2, Ping Zhou 3, Chengbin Xue 4, Yunyi Nan 1, Yingchen Ni 1, Xinyuan Wu 1, Zhifeng Gu 2, Minhao Chen 1, Youhua Wang 1 Affiliations expand Abstract Pyroptosis, an inflammatory form of programmed cell death, is linked to the pathology of rheumatoid arthritis (RA). …

ALOX5 drives the pyroptosis of CD4+ T cells and tissue inflammation in rheumatoid arthritis 더 보기 »

Safety and feasibility of anti-CD19 CAR T cells expressing inducible IL-7 and CCL19 in patients with relapsed or refractory large B-cell lymphoma

댓글 달기 / BioGems / 글쓴이

Annexin V apoptosis detection kit ; 62700 ; Cell Discov. 2024 Jan 9;10(1):5. doi: 10.1038/s41421-023-00625-0. Wen Lei # 1 2, Ai Zhao # 3 4, Hui Liu # 1 2, Chunmei Yang 2, Cheng Wei 3, Shanshan Guo 1, Zhilu Chen 5, Qunyi Guo 6, Linjie Li 7, Mingzhe Zhao 8, Gongqiang Wu 9, Guifang Ouyang 10, Ming Liu 11, Jinyi Zhang 12, Jimin Gao 13 14, Wenbin Qian 15 16 Affiliations expand Abstract Although CD19-specific chimeric antigen receptor (CAR) T cells are curative for patients with relapsed or refractory large B-cell lymphoma (R/R LBCL), …

Safety and feasibility of anti-CD19 CAR T cells expressing inducible IL-7 and CCL19 in patients with relapsed or refractory large B-cell lymphoma 더 보기 »

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