Generation, genomic characterization, and differentiation of triploid human embryonic stem cells

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#SB 431542; #LDN 193189;  #3014193; #1066208; Guy Haim-Abadi 1, Tamar Golan-Lev 1, Amnon Koren 2, Nissim Benvenisty 3 Affiliations expand Free PMC article Abstract Humans are diploid organisms, and triploidy in human embryos is responsible for ∼10% of spontaneous miscarriages. Surprisingly, some pregnancies proceed to triploid newborns that suffer from many neuro-developmental disorders. To investigate the impact of triploidy on human development, we …

Generation, genomic characterization, and differentiation of triploid human embryonic stem cells 더 보기 »

Single-cell transcriptome sequencing of B-cell heterogeneity and tertiary lymphoid structure predicts breast cancer prognosis and neoadjuvant therapy efficacy

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#10X RBC Lysis Buffer; #64010‐00‐100 Clin Transl Med. 2023 Aug;13(8):e1346. doi: 10.1002/ctm2.1346. Qing Wang 1, Ke Sun 2 3, Rui Liu 1, Ying Song 1, Yafeng Lv 1, Pingping Bi 1, Fuying Yang 1, Sijia Li 1, Jiawen Zhao 1, Xiuqin Li 1, Dong Chen 4, Jialin Mei 5, Rirong Yang 6 7, Kai Chen 2 3, Dequan Liu 1, Shichong Tang 1 Affiliations expand Free PMC article Abstract Background: Breast cancer (BC) is a highly heterogeneous disease, and although immunotherapy has recently increased patient survival in a number of solid …

Single-cell transcriptome sequencing of B-cell heterogeneity and tertiary lymphoid structure predicts breast cancer prognosis and neoadjuvant therapy efficacy 더 보기 »

Epigallocatechin gallate (EGCG) can epigenetically regulate the receptor of advanced glycation end products (RAGE) to ameliorate Osteoarthritis

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#Human IL-6 Pre-Coated ELISA Kit;  Human TNF-α Pre-Coated ELISA Kit; #BGK05231;  BGK01375 J. Funct. Foods,V107,2023,105682,ISSN 1756-4646,https://doi.org/10.1016/j.jff.2023.105682. Xiaoqing Wu ab, Xuanren Shi c, Xiaoyong Chen b, Zhanhai Yin a Abstract Epigallocatechin-3-O-gallate is natural phytochemical of green tea. RAGE upregulation promotes osteoarthritis (OA) progression. Herein, we revealed that EGCG can repress RAGE expression epigenetically to ameliorate OA. Firstly we found that RAGE expression was dose-dependently reduced by EGCG …

Epigallocatechin gallate (EGCG) can epigenetically regulate the receptor of advanced glycation end products (RAGE) to ameliorate Osteoarthritis 더 보기 »

Activation of cAMP (EPAC2) signaling pathway promotes hepatocyte attachment

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#BIO; Dexamethasone; Calcitriol;  Forskolin; IBMX;   #6676296; 5000222; 3220632;  6652995;  2885842  Sci Rep 13, 12352 (2023). https://doi.org/10.1038/s41598-023-39712-3 Abstract Primary Human Hepatocyte (PHH) remains undefeated as the gold standard in hepatic studies. Despite its valuable properties, partial attachment loss due to the extraction process and cryopreservation remained the main hurdle in its application. We hypothesized that we …

Activation of cAMP (EPAC2) signaling pathway promotes hepatocyte attachment 더 보기 »

Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation

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#IWP2; #6866167 Cell Stem Cell. 2023 Jul 6;30(7):973-986.e11. doi: 10.1016/j.stem.2023.05.015. Min Seong Kim 1, Eun A Ra 1, Sin Ho Kweon 1, Bo Am Seo 2, Han Seok Ko 3, Yohan Oh 4, Gabsang Lee 5 Affiliations expand Abstract Human induced pluripotent stem cells (hiPSCs) offer advantages for disease modeling and drug discovery. However, recreating innate cellular pathologies, particularly in late-onset neurodegenerative diseases with accumulated protein aggregates including Parkinson’s …

Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation 더 보기 »

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