Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids

댓글 달기 / BioGems, Small Molecules / 글쓴이

Nat Commun. 2021 Dec 15;12(1):7302. doi: 10.1038/s41467-021-27464-5. Alessandro Fiorenzano 1, Edoardo Sozzi 2, Marcella Birtele 2, Janko Kajtez 2, Jessica Giacomoni 2, Fredrik Nilsson 2, Andreas Bruzelius 3, Yogita Sharma 2, Yu Zhang 2, Bengt Mattsson 2, Jenny Emnéus 4, Daniella Rylander Ottosson 3, Petter Storm 2, Malin Parmar 2 PMID: 34911939 PMCID: PMC8674361 DOI: 10.1038/s41467-021-27464-5 Abstract Three-dimensional brain organoids have emerged as a valuable model system for studies of human brain development and pathology. Here we establish a midbrain organoid culture system to study …

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Using hiPSC-CMs to Examine Mechanisms of Catecholaminergic Polymorphic Ventricular Tachycardia

댓글 달기 / ROCK inhibitor, Small Molecules, Y-27632 / 글쓴이

Curr Protoc. 2021 Dec;1(12):e320. doi: 10.1002/cpz1.320. Alia Arslanova 1 2, Sanam Shafaattalab 1 2, Kevin Ye 1 2, Parisa Asghari 3, Lisa Lin 1 2, BaRun Kim 2, Thomas M Roston 4, Leif Hove-Madsen 5, Filip Van Petegem 6, Shubhayan Sanatani 4, Edwin Moore 5, Francis Lynn 1, Mads Søndergaard 7, Yonglun Luo 7, S R Wayne Chen 8, Glen F Tibbits 1 2 9 PMID: 34958715 DOI: 10.1002/cpz1.320 Abstract Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal inherited cardiac arrhythmia condition, triggered by physical or acute emotional stress, that predominantly expresses early …

Using hiPSC-CMs to Examine Mechanisms of Catecholaminergic Polymorphic Ventricular Tachycardia 더 보기 »

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