Upregulated ECM genes and increased synaptic activity in Parkinson’s human DA neurons with PINK1/ PRKN mutations

댓글 달기 / BioGems, CHIR 99021, Small Molecules, Stem cell research / 글쓴이

#L-Ascorbic Acid ; #Dibutyryl-cAMP, sodium salt ; #LDN193189 Hydrochloride ; #Purmorphamine ; #SAG ; #CHIR 99021 ; # 5088177 ; #1698950 ; #1066208 ; #4831086 ; #9128694 ; #2520691 ; NPJ Parkinsons Dis. 2024 May 18;10(1):103. Utkarsh Tripathi 1, Idan Rosh 1, Ran Ben Ezer 1, Ritu Nayak 1, Yara Hussein 1, Ashwani Choudhary 1, Jose Djamus 1, Andreea Manole 2, Henry Houlden 3, Fred H Gage 2, Shani Stern 4 Affiliations expand Abstract Parkinson’s disease (PD) …

Upregulated ECM genes and increased synaptic activity in Parkinson’s human DA neurons with PINK1/ PRKN mutations 더 보기 »

Substrate mechanics unveil early structural and functional pathology in iPSC micro-tissue models of hypertrophic cardiomyopathy

댓글 달기 / BioGems, CHIR 99021, ROCK inhibitor, Small Molecules, Stem cell research, WNT pathway, Y-27632 / 글쓴이

#Y-27632 ; #CHIR 99021 ; #IWP2 ; #1293823 ; #2520691 ; #6866167 ; iScience, 2024, 109954. Jingxuan Guo 1, Huanzhu Jiang 2, David Schuftan 2, Jonathan D. Moreno 4, Ghiska Ramahdita 1 3, Lavanya Aryan 2, Druv Bhagavan 2, Jonathan Silva 2, Nathaniel Huebsch 2 3 5 6 Summary Hypertension is a major cause of morbidity and mortality in patients with hypertrophic cardiomyopathy (HCM), suggesting a potential role for mechanics in HCM pathogenesis. Here, we developed an in vitro physiological model to investigate how mechanics acts together with …

Substrate mechanics unveil early structural and functional pathology in iPSC micro-tissue models of hypertrophic cardiomyopathy 더 보기 »

Photoactivatable Aptamer-CRISPR Nanodevice Enables Precise Profiling of Interferon-Gamma Release in Humanized Mice

댓글 달기 / BioGems, Small Molecules, Stem cell research / 글쓴이

#Phorbol 12-myristate 13-acetate (PMA) ; #Ionomycin Calcium Salt ; #Brefeldin A ;  #1652981 ; #5608212 ; #2031560 ;   ACS Nano. 2024 Jan 30;18(4):3826-3838. Zheng Liu 1, Xiang Duan 2, Yangfang Yun 1, Siqi Li 2, Zhiyuan Feng 1, Jiayin Zhan 1, Ran Liu 1, Yan Li 2, Jingjing Zhang 1 Affiliations expand Abstract Real-time dynamic imaging of immunoactivation-related cytokines is crucial for evaluating the efficacy of immune checkpoint blockade therapy and optimizing the …

Photoactivatable Aptamer-CRISPR Nanodevice Enables Precise Profiling of Interferon-Gamma Release in Humanized Mice 더 보기 »

Dynamic control of contractile resistance to iPSC-derived micro-heart muscle arrays

댓글 달기 / BioGems, CHIR 99021, Small Molecules, Stem cell research, WNT pathway / 글쓴이

#CHIR 99021 ; #IWP2 ; #2520691 ; #6866167 ; J Biomed Mater Res A. 2024 Apr;112(4):534-548 David Schuftan 1, Yasaman Kargar Gaz Kooh 2, Jingxuan Guo 3, Yuwen Sun 2, Lavanya Aryan 1, Bryce Stottlemire 4, Cory Berkland 4 5, Guy M Genin 3 6, Nathaniel Huebsch 1 6 Affiliations expand Abstract Many types of cardiovascular disease are linked to the mechanical forces placed on the heart. However, our understanding of how mechanical forces exactly affect …

Dynamic control of contractile resistance to iPSC-derived micro-heart muscle arrays 더 보기 »

Optimized and Scalable Precoating-Free Reprogramming of Human Peripheral Blood Mononuclear Cells into iPSCs

댓글 달기 / extracellular matrix and substrate, Stem cell research / 글쓴이

#BG iMatrix-511 Silk ;  #RL511S ; #ECM ; Curr Protoc. 2024 Jan;4(1):e979. doi: 10.1002/cpz1.979. Elisabetta Fiacco 1, Sara Landi 1, Jacopo Zasso 1, Chiara Ambrosini 1, Giovanni Faga 1 Affiliations expand Abstract Human disease modeling has been profoundly transformed by the introduction of human induced pluripotent stem cells (iPSCs), marking the onset of a new era. This ground-breaking development offers a tailored framework for generating …

Optimized and Scalable Precoating-Free Reprogramming of Human Peripheral Blood Mononuclear Cells into iPSCs 더 보기 »

Regulated intestinal microbiota and gut immunity to ameliorate type 1 diabetes mellitus: A novel mechanism for stem cell-based therapy

댓글 달기 / Small Molecules, Stem cell research / 글쓴이

# Phorbol 12-myristate 13-acetate (PMA) ; #Ionomycin Calcium Salt ; #Brefeldin A; #1652981 ; #5608212 ; #2031560 Biomed Pharmacother. 2024 Jan:170:116033. doi: 10.1016/j.biopha.2023.116033.  Shu-Juan Zheng 1, Yi Luo 2, Jian-Bin Wang 2, Xue-Mei Chen 3, Yan Xu 2, Jian-Hui Xiao 4 Abstract Although stem cell transplantation is an effective strategy in the treatment of type 1 diabetes mellitus (T1DM), the mechanisms underlying its therapeutic effects remain unclear. …

Regulated intestinal microbiota and gut immunity to ameliorate type 1 diabetes mellitus: A novel mechanism for stem cell-based therapy 더 보기 »

The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor

댓글 달기 / BioGems, Small Molecules, Stem cell research / 글쓴이

#SB431542 ; #dorsomorphin ; #cAMP ;  #3014193 ; #8666430 ; #6099240 ;  Debbra Y Knorr 1, Ignacio Rodriguez Polo 2 3 4 5, Hanna S Pies 1, Nicola Schwedhelm-Domeyer 1, Stephanie Pauls 1, Rüdiger Behr 3 4, Ralf Heinrich 1 Affiliations expand Free PMC article Abstract The evolutionary conserved orphan cytokine receptor-like factor 3 (CRLF3) has been implicated in human disease, vertebrate hematopoiesis and insect neuroprotection. While its specific functions are elusive, experimental …

The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor 더 보기 »

Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy

댓글 달기 / BioGems, CHIR 99021, Small Molecules, Stem cell research, WNT pathway / 글쓴이

#CHIR 99021 ; #2520691 ; J Clin Invest. 2023 Aug 10;e171356. doi: 10.1172/JCI171356. Meha Kabra 1 2, Pawan K Shahi 1 2, Yuyuan Wang 3 4, Divya Sinha 2 5, Allison Spillane 1, Gregory A Newby 6 7 8, Shivani Saxena 2 3 4, Yao Tong 3 4, Yu Chang 1, Amr A Abdeen 2 3 4, Kimberly L Edwards 2 5, Cole O Theisen 5, David R Liu 6 7 8, David M Gamm 2 5 9, Shaoqin Gong 2 3 4 9, Krishanu Saha 1 2 3 4 10, Bikash R Pattnaik 1 2 9 Affiliations expand Free PMC article Abstract Clinical genome editing is emerging for rare disease treatment, but one …

Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy 더 보기 »

Abnormal developmental trajectory and vulnerability to cardiac arrhythmias in tetralogy of Fallot with DiGeorge syndrome

댓글 달기 / BioGems, ROCK inhibitor, Small Molecules, Stem cell research, Y-27632 / 글쓴이

#Y-27632 ; #1293823 ; Cells 2023, 12(18), 2319; https://doi.org/10.3390/cells12182319 Chun-Ho Chan 1, Yin-Yu Lam 1, Nicodemus Wong 1, Lin Geng 1, Jilin Zhang 2, Virpi Ahola 2, Aman Zare 2, Ronald Adolphus Li 2 3, Fredrik Lanner 4 5 6, Wendy Keung 3, Yiu-Fai Cheung 7 8 9 Affiliations expand Abstract Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. Ventricular dysfunction and cardiac arrhythmias are well-documented complications in patients with repaired TOF. Whether intrinsic abnormalities exist in TOF …

Abnormal developmental trajectory and vulnerability to cardiac arrhythmias in tetralogy of Fallot with DiGeorge syndrome 더 보기 »

Modeling of FAN1-Deficient Kidney Disease Using a Human Induced Pluripotent Stem Cell-Derived Kidney Organoid System

댓글 달기 / BioGems, ROCK inhibitor, Small Molecules, Stem cell research, Y-27632 / 글쓴이

#Y-27632 ; #1293823 ; Commun Biol. 2023 Sep 22;6(1):969. doi: 10.1038/s42003-023-05344-6. Sun Woo Lim, Dohyun Na, Hanbi Lee, Xianying Fang, Sheng Cui, Yoo Jin Shin, Kang In Lee, Jae Young Lee, Chul Woo Yang and Byung Ha Chung Abstract Karyomegalic interstitial nephritis (KIN) is a genetic kidney disease caused by mutations in the FANCD2/FANCI-Associated Nuclease …

Modeling of FAN1-Deficient Kidney Disease Using a Human Induced Pluripotent Stem Cell-Derived Kidney Organoid System 더 보기 »

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