Decidualization Potency and Epigenetic Changes in Human Endometrial Origin Stem Cells During Propagation

댓글 달기 / BioGems / 글쓴이

Front Cell Dev Biol. 2021 Nov 19;9:765265. doi: 10.3389/fcell.2021.765265. eCollection 2021. Elvina Valatkaitė 1, Raminta Baušytė 1 2, Aida Vitkevičienė 1, Diana Ramašauskaitė 2, Rūta Navakauskienė 1 PMID: 34869358 PMCID: PMC8640123 DOI: 10.3389/fcell.2021.765265 Abstract Human endometrium derived mesenchymal stem cells (hEndSCs) offer a great promise for regenerative medicine and reproductive system disorders treatment methods based on cell therapy due to their broad differentiation potential and highly efficient proliferation. …

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Identifying regulators of parental imprinting by CRISPR/Cas9 screening in haploid human embryonic stem cells

댓글 달기 / Small Molecules / 글쓴이

Nat Commun. 2021 Nov 18;12(1):6718. doi: 10.1038/s41467-021-26949-7. Shiran Bar 1, Dan Vershkov 1, Gal Keshet 1, Elyad Lezmi 1, Naama Meller 1, Atilgan Yilmaz 1, Ofra Yanuka 1, Malka Nissim-Rafinia 2 3, Eran Meshorer 2 3, Talia Eldar-Geva 4 5, Nissim Benvenisty 6 PMID: 34795250 PMCID: PMC8602306 DOI: 10.1038/s41467-021-26949-7 Abstract In mammals, imprinted genes are regulated by differentially methylated regions (DMRs) that are inherited from germ cells, leading to monoallelic expression in accordance with parent-of-origin. Yet, it is largely unknown how imprinted …

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Interleukin-36α inhibits colorectal cancer metastasis by enhancing the infiltration and activity of CD8+ T lymphocytes

댓글 달기 / Buffers and Solutions / 글쓴이

Int Immunopharmacol. 2021 Nov;100:108152. doi: 10.1016/j.intimp.2021.108152. Epub 2021 Sep 21. Xiuyu Wei 1, Yongjie Yao 1, Xiaoxi Wang 1, Jiaxin Sun 1, Wenshan Zhao 2, Lu Qiu 2, Wenjie Zhai 2, Yuanming Qi 2, Yanfeng Gao 3, Yahong Wu 4 PMID: 34555640 DOI: 10.1016/j.intimp.2021.108152 Abstract Colorectal cancer is one of the deadliest cancers, and the discovery of new diagnostic biomarkers and therapeutic targets is vital. Interleukin-36α (IL-36α) is a proinflammatory factor that can initiate the inflammatory …

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Insulin signaling alters antioxidant capacity in the diabetic heart

댓글 달기 / Small Molecules / 글쓴이

Redox Biol. 2021 Nov;47:102140. doi: 10.1016/j.redox.2021.102140. Epub 2021 Sep 20. Satoshi Matsuzaki 1, Craig Eyster 1, Maria F Newhardt 2, Jennifer R Giorgione 1, Caroline Kinter 1, Zachary T Young 1, Michael Kinter 1, Kenneth M Humphries 3 PMID: 34560411 PMCID: PMC8473541 DOI: 10.1016/j.redox.2021.102140 Abstract Diabetic cardiomyopathy is associated with an increase in oxidative stress. However, antioxidant therapy has shown a limited capacity to mitigate disease pathology. The molecular mechanisms responsible for the …

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