Early host immune responses in a human organoid-derived gallbladder monolayer to Salmonella Typhi strains from patients with acute and chronic infections: a comparative analysis

댓글 달기 / BioGems, ROCK inhibitor, Small Molecules, Y-27632 / 글쓴이

Y-27632 ; 1293823 ; Front Immunol. 2024 Mar 12:15:1334762. doi: 10.3389/fimmu.2024.1334762. eCollection 2024 Rosângela Salerno-Goncalves 1, Haiyan Chen 1, Andrea C Bafford 2, Mariana Izquierdo 1, Juan Carlos Hormazábal 3, Rosanna Lagos 3, Hervé Tettelin 4, Adonis D’Mello 4, Jayaum S Booth 1, Alessio Fasano 5, Myron M Levine 1, Marcelo B Sztein 1 6 Affiliations expand Abstract Salmonella enterica serovar Typhi (S. Typhi), a human-restricted pathogen, invades the host through the gut to cause typhoid fever. Recent calculations of the …

Early host immune responses in a human organoid-derived gallbladder monolayer to Salmonella Typhi strains from patients with acute and chronic infections: a comparative analysis 더 보기 »

Protocol for the establishment and characterization of an endometrial-derived epithelial organoid and stromal cell co-culture system

댓글 달기 / Small Molecules / 글쓴이

#A 83-01 ; #Nicotinamide ; #9094360 ; #9899208 ; STAR Protoc. 2024 Feb 15;5(1):102894. Jason A Rizo 1, Thomas E Spencer 2, Andrew M Kelleher 3 Abstract Postnatal development of the uterus involves the specification of undifferentiated epithelium into uterine-type epithelium. That specification is regulated by stromal-epithelial interactions as well as intrinsic cell-specific transcription factors and gene regulatory networks. Here, …

Protocol for the establishment and characterization of an endometrial-derived epithelial organoid and stromal cell co-culture system 더 보기 »

The effector program of human CD8 T cells supports tissue remodeling

댓글 달기 / Small Molecules / 글쓴이

#A 83-01 ;  #9094360 ; J Exp Med. 2024 Feb 5;221(2):e20230488. doi: 10.1084/jem.20230488. Michael Delacher # 1 2 3 4, Lisa Schmidleithner # 1 2, Malte Simon # 1 5 6, Philipp Stüve # 1 2, Lieke Sanderink 1 2, Agnes Hotz-Wagenblatt 7, Marina Wuttke 1 2, Kathrin Schambeck 1 2, Brigitte Ruhland 1 2, Veronika Hofmann 1 2, Sebastian Bittner 1 2, Uwe Ritter 1 2, Asmita Pant 1 2, Sara Salome Helbich 3 4, Morten Voss 3 4, Niels A Lemmermann 4 8 9, Lisa Bessiri-Schake 3 4, Toszka Bohn 3 4, Andreas Eigenberger 10, Ayse Nur Menevse 1 11, Claudia Gebhard 1, Nicholas Strieder 1, Hinrich Abken 1 12, Michael Rehli 1 13, Jochen Huehn 14 15 16, Philipp Beckhove 1 11 13, Thomas Hehlgans 1 2, Henrik Junger 17, Edward K Geissler 17, Lukas Prantl 10, Jens M Werner 17, Christian Schmidl 1, Benedikt Brors 5 18 6 19 20, Charles D Imbusch 3 4 6, Markus Feuerer 1 2 …

The effector program of human CD8 T cells supports tissue remodeling 더 보기 »

Three-Dimensional Cell Culture of Epididymal Basal Cells and Organoids: A Novel Tool for Toxicology

댓글 달기 / ROCK inhibitor, Small Molecules, Y-27632 / 글쓴이

#Y-27632 ; #1293823 ; #ROCK inhibitor ; Curr Protoc. 2024 Jan;4(1):e975. doi: 10.1002/cpz1.975. Julie Dufresne 1, Mary Gregory 1, Laurie Pinel 1, Daniel G Cyr 1 Affiliations expand Abstract Spermatozoa are formed in the testis but must transit through the epididymis to acquire motility and the ability to fertilize. The epididymis is a single convoluted tubule comprising several anatomically and physiologically distinct regions. …

Three-Dimensional Cell Culture of Epididymal Basal Cells and Organoids: A Novel Tool for Toxicology 더 보기 »

Engineered cocultures of iPSC-derived atrial cardiomyocytes and atrial fibroblasts for modeling atrial fibrillation

댓글 달기 / Small Molecules / 글쓴이

#Dexamethasone ; #5000222 ; Sci Adv. 2024 Jan 19;10(3):eadg1222. doi: 10.1126/sciadv.adg1222. Grace E Brown 1, Yong Duk Han 1, Ashlin R Michell 1, Olivia T Ly 1 2, Carlos G Vanoye 3, Emanuele Spanghero 1, Alfred L George Jr 3, Dawood Darbar 1 2 4 5, Salman R Khetani 1 Abstract Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia treatable with antiarrhythmic drugs; however, patient responses remain highly variable. Human induced pluripotent stem cell-derived …

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Regulated intestinal microbiota and gut immunity to ameliorate type 1 diabetes mellitus: A novel mechanism for stem cell-based therapy

댓글 달기 / Small Molecules, Stem cell research / 글쓴이

# Phorbol 12-myristate 13-acetate (PMA) ; #Ionomycin Calcium Salt ; #Brefeldin A; #1652981 ; #5608212 ; #2031560 Biomed Pharmacother. 2024 Jan:170:116033. doi: 10.1016/j.biopha.2023.116033.  Shu-Juan Zheng 1, Yi Luo 2, Jian-Bin Wang 2, Xue-Mei Chen 3, Yan Xu 2, Jian-Hui Xiao 4 Abstract Although stem cell transplantation is an effective strategy in the treatment of type 1 diabetes mellitus (T1DM), the mechanisms underlying its therapeutic effects remain unclear. …

Regulated intestinal microbiota and gut immunity to ameliorate type 1 diabetes mellitus: A novel mechanism for stem cell-based therapy 더 보기 »

Epigenetic repression of CHCHD2 enhances survival from single cell dissociation through attenuated Rho A kinase activity

댓글 달기 / ROCK inhibitor, Small Molecules, Y-27632 / 글쓴이

#Y-27632 ; #1293823 ; Jumee Kim # 1, Eun-Ji Kwon # 1, Yun-Jeong Kim 1, Dayeon Kim 1, Yoon-Ze Shin 1, Dayeon Gil 2 3, Jung-Hyun Kim 2 3, Hyoung Doo Shin 4 5, Lyoung Hyo Kim 6, Mi-Ok Lee 7, Young-Hyun Go 8 9, Hyuk-Jin Cha 10 11 Abstract During in vitro culture, human pluripotent stem cells (hPSCs) often acquire survival advantages characterized by decreased susceptibility to mitochondrial cell death, known as “culture adaptation.” This adaptation is associated with genetic and epigenetic abnormalities, including …

Epigenetic repression of CHCHD2 enhances survival from single cell dissociation through attenuated Rho A kinase activity 더 보기 »

SMYD3 promotes endometrial cancer through epigenetic regulation of LIG4/XRCC4/XLF complex in non-homologous end joining repair

댓글 달기 / Small Molecules / 글쓴이

#BrdU  ; #5911439 ; Oncogenesis. 2024 Jan 8;13(1):3. doi: 10.1038/s41389-023-00503-0. Yujia Huang # 1, Ming Tang # 2, Zhiyi Hu # 1, Bailian Cai 1, Guofang Chen 1, Lijun Jiang 1, Yan Xia 1, Pujun Guan 3, Xiaoqi Li 4, Zhiyong Mao 1, Xiaoping Wan 5, Wen Lu 6 Abstract Endometrial cancer (EC) stands as one of the most prevalent malignancies affecting the female genital tract, witnessing a rapid surge in incidence globally. Despite the well-established association of histone methyltransferase SMYD3 …

SMYD3 promotes endometrial cancer through epigenetic regulation of LIG4/XRCC4/XLF complex in non-homologous end joining repair 더 보기 »

Endometrial organoids: a reservoir of functional mitochondria for uterine repair

댓글 달기 / ROCK inhibitor, Small Molecules, Y-27632 / 글쓴이

#Y-27632 ; #Nicotinamide ; #1293823 ; #9899208 ; Theranostics. 2024 Jan 1;14(3):954-972. doi: 10.7150/thno.90538. Sun-Young Hwang 1, Danbi Lee 1, Gaeun Lee 1, Jungho Ahn 2, Yu-Gyeong Lee 1, Hwa Seon Koo 3, Youn-Jung Kang 1 2 Abstract Background: Asherman’s syndrome (AS) is a dreadful gynecological disorder of the uterus characterized by intrauterine adhesion with severe fibrotic lesions, resulting in a damaged basalis layer with infertility. Despite extensive research on …

Endometrial organoids: a reservoir of functional mitochondria for uterine repair 더 보기 »

The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor

댓글 달기 / BioGems, Small Molecules, Stem cell research / 글쓴이

#SB431542 ; #dorsomorphin ; #cAMP ;  #3014193 ; #8666430 ; #6099240 ;  Debbra Y Knorr 1, Ignacio Rodriguez Polo 2 3 4 5, Hanna S Pies 1, Nicola Schwedhelm-Domeyer 1, Stephanie Pauls 1, Rüdiger Behr 3 4, Ralf Heinrich 1 Affiliations expand Free PMC article Abstract The evolutionary conserved orphan cytokine receptor-like factor 3 (CRLF3) has been implicated in human disease, vertebrate hematopoiesis and insect neuroprotection. While its specific functions are elusive, experimental …

The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor 더 보기 »

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