Direct Induction of the Three Pre-implantation Blastocyst Cell Types from Fibroblasts

https://pubmed.ncbi.nlm.nih.gov/31031139/ Cell Stem Cell. 2019 Jun 6;24(6):983-994.e7. doi: 10.1016/j.stem.2019.03.018. Epub 2019 Apr 25. Hana Benchetrit 1, Mohammad Jaber 1, Valery Zayat 1, Shulamit Sebban 1, Avital Pushett 1, Kirill Makedonski 1, Zvi Zakheim 1, Ahmed Radwan 1, Noam Maoz 1, Rachel Lasry 1, Noa Renous 1, Michal Inbar 1, Oren Ram 2, Tommy Kaplan 3, Yosef Buganim 4 PMID: 31031139 PMCID: PMC6561721 DOI: 10.1016/j.stem.2019.03.018 Abstract Following fertilization, totipotent cells undergo asymmetric cell divisions, resulting in three distinct cell types in the late pre-implantation blastocyst: epiblast (Epi), primitive …

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