Programming Cellular Alignment in Engineered Cardiac Tissue via Bioprinting Anisotropic Organ Building Blocks

댓글 달기 / CHIR 99021, ROCK inhibitor, Small Molecules, WNT pathway, Y-27632 / 글쓴이

# Y-27635, Biogems, # CHIR 99021, Biogems Adv Mater. 2022 Jul;34(26):e2200217. doi: 10.1002/adma.202200217. Epub 2022 May 25. John H Ahrens 1 2, Sebastien G M Uzel 1 2, Mark Skylar-Scott 1 2, Mariana M Mata 1 2, Aric Lu 1 2, Katharina T Kroll 1 2, Jennifer A Lewis 1 2 Abstract The ability to replicate the 3D myocardial architecture found in human hearts is a grand challenge. Here, the fabrication of aligned cardiac tissues …

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Controlling neural territory patterning from pluripotency using a systems developmental biology approach

댓글 달기 / CHIR 99021, Small Molecules, Stem cell research, WNT pathway / 글쓴이

#A83-01 9094360 BioGems, #LDN-193189 1066208 BioGems, #CHIR 99021 Biogems Cat# 2520691, #XAV939 Biogems Cat# 2848932 iScience. 2022 Mar 21;25(4):104133. doi: 10.1016/j.isci.2022.104133. eCollection 2022 Apr 15. Katie E Sears 1 2 3, Keerthi Gullapalli 3, Divya Trivedi 3, Alexander Mihas 2, Michael A Bukys 2 3, Jan Jensen 1 2 3 Abstract Successful manufacture of specialized human cells requires process understanding of directed differentiation. Here, we apply high-dimensional Design of Experiments (HD-DoE) …

Controlling neural territory patterning from pluripotency using a systems developmental biology approach 더 보기 »

Mutant ANP induces mitochondrial and ion channel remodeling in a human iPSC-derived atrial fibrillation model

댓글 달기 / Small Molecules, Stem cell research / 글쓴이

#dexamethasone (Biogems) JCI Insight. 2022 Apr 8;7(7):e155640. doi: 10.1172/jci.insight.155640. Olivia T Ly 1 2, Hanna Chen 1, Grace E Brown 2, Liang Hong 1, Xinge Wang 1 2, Yong Duk Han 2, Mahmud Arif Pavel 1, Arvind Sridhar 1 3, Mark Maienschein-Cline 4, Brandon Chalazan 1, Sang-Ging Ong 1 5, Khaled Abdelhady 6, Malek Massad 6, Lona Ernst Rizkallah 6, Jalees Rehman 1 2 6, Salman R Khetani 2, Dawood Darbar 1 2 3 6 Free PMC article Abstract Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) can model heritable arrhythmias to personalize therapies for individual patients. Although …

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Orthogonally induced differentiation of stem cells for the programmatic patterning of vascularized organoids and bioprinted tissues

댓글 달기 / CHIR 99021, Small Molecules, Stem cell research, WNT pathway / 글쓴이

#SB431542 (BioGems, 3014193) , #LDN193189 (BioGems, 1066208), #CHIR99021 (BioGems, 2520691) Nat Biomed Eng. 2022 Apr;6(4):449-462. doi: 10.1038/s41551-022-00856-8. Mark A Skylar-Scott # 1 2 3 4, Jeremy Y Huang # 5 6 7, Aric Lu # 5 6 8, Alex H M Ng 5 7, Tomoya Duenki 5 6, Songlei Liu 5 7, Lucy L Nam 5 6, Sarita Damaraju 5 6, George M Church 5 7, Jennifer A Lewis 9 10 Free PMC article Abstract The generation of organoids and tissues with programmable cellular complexity, architecture and function would benefit from …

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Generation of human tonsil epithelial organoids as an ex vivo model for SARS-CoV-2 infection

댓글 달기 / BioGems, Small Molecules / 글쓴이

#prostaglandin E2 (BioGems) Biomaterials. 2022 Apr;283:121460. doi: 10.1016/j.biomaterials.2022.121460. Epub 2022 Mar 7. Han Kyung Kim 1, Hyeryeon Kim 2, Myoung Kyu Lee 3, Woo Hee Choi 4, Yejin Jang 3, Jin Soo Shin 3, Jun-Yeol Park 4, Dong Hyuck Bae 4, Seong-In Hyun 5, Kang Hyun Kim 6, Hyun Wook Han 6, Byungho Lim 7, Gildon Choi 8, Meehyein Kim 9, Young Chang Lim 10, Jongman Yoo 11 Affiliations expand Free PMC article Abstract The palatine tonsils (hereinafter referred to as “tonsils”) serve as a reservoir for …

Generation of human tonsil epithelial organoids as an ex vivo model for SARS-CoV-2 infection 더 보기 »

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