Structure-based design, synthesis and biological evaluation of aminopyrazines as highly potent, selective, and cellularly active allosteric SHP2 inhibitors

댓글 달기 / Buffers and Solutions / 글쓴이

Eur J Med Chem. 2022 Feb 15;230:114106. doi: 10.1016/j.ejmech.2022.114106. Epub 2022 Jan 12. Kai Tang 1, Min Zhao 1, Ya-Hong Wu 2, Qiong Wu 1, Shu Wang 1, Yu Dong 2, Bin Yu 3, Yihui Song 4, Hong-Min Liu 5 Abstract Src homology-2-containing protein tyrosine phosphatase 2 (SHP2) encoded by the proto-oncogene PTPN11 is the first identified non-receptor protein tyrosine phosphatase. SHP2 dysregulation contributes to the pathogenesis of different cancers, making SHP2 …

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Assessment of source material for human intestinal organoid culture for research and clinical use

댓글 달기 / ROCK inhibitor, Small Molecules, Y-27632 / 글쓴이

https://pubmed.ncbi.nlm.nih.gov/35144661/ Paulo C M Urbano 1 2, Hamish C K Angus 1, Safina Gadeock 3, Michael Schultz 2 4, Roslyn A Kemp 5Affiliations expand PMID: 35144661 PMCID: PMC8830126 DOI: 10.1186/s13104-022-05925-4 Abtract Objective: Human intestinal organoids (hIOs) have potential as a model for investigating intestinal diseases. The hIO system faces logistic challenges including limited access to biopsies or low expression of epithelial cell types. Previous research identified the feasibility of tissue from …

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Generation of individualized immunocompatible endothelial cells from HLA-I-matched human pluripotent stem cells

댓글 달기 / Small Molecules, Stem cell research / 글쓴이

#PMA (phorbol 12-myristate-13-acetate) (Biogems, 1652981) # ionomycin (Biogems, 5608212) Stem Cell Res Ther. 2022 Feb 2;13(1):48. doi: 10.1186/s13287-022-02720-7. Chanchan Song # 1, Linli Wang # 2 3, Qingyang Li 1, Baoyi Liao 1, Weihua Qiao 4, Qiang Li 2 3, Nianguo Dong 5, Liangping Li 6 Affiliations expand Free PMC article Erratum in Abstract Background: Endothelial cells (ECs) derived from human-induced pluripotent stem cell (iPSC) are a valuable cell resource for cardiovascular regeneration. To avoid time-consuming …

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