Benzosceptrin C induces lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting DHHC3

댓글 달기 / BioGems / 글쓴이

#Anti-Human/Mouse CD11b FITC ;  #03221-50 ;  Cell Rep Med. 2024 Feb 20;5(2):101357. Hongwei Zhang 1, Saisai Tian 2, Guangyong Zheng 1, Dong Lu 1, Jiajia Hu 3, Mengmeng Guo 1, Minchen Cai 1, Xiangxin Geng 1, Yanyan Zhang 1, Jianhua Xia 1, Xing Zhang 1, Ang Li 4, Sanhong Liu 5, Weidong Zhang 6 Affiliations expand Abstract Programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) blockade has become a mainstay of cancer immunotherapy. Targeting the PD-1/PD-L1 axis with small molecules is an attractive …

Benzosceptrin C induces lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting DHHC3 더 보기 »

Upregulated ECM genes and increased synaptic activity in Parkinson’s human DA neurons with PINK1/ PRKN mutations

댓글 달기 / BioGems, CHIR 99021, Small Molecules, Stem cell research / 글쓴이

#L-Ascorbic Acid ; #Dibutyryl-cAMP, sodium salt ; #LDN193189 Hydrochloride ; #Purmorphamine ; #SAG ; #CHIR 99021 ; # 5088177 ; #1698950 ; #1066208 ; #4831086 ; #9128694 ; #2520691 ; NPJ Parkinsons Dis. 2024 May 18;10(1):103. Utkarsh Tripathi 1, Idan Rosh 1, Ran Ben Ezer 1, Ritu Nayak 1, Yara Hussein 1, Ashwani Choudhary 1, Jose Djamus 1, Andreea Manole 2, Henry Houlden 3, Fred H Gage 2, Shani Stern 4 Affiliations expand Abstract Parkinson’s disease (PD) …

Upregulated ECM genes and increased synaptic activity in Parkinson’s human DA neurons with PINK1/ PRKN mutations 더 보기 »

Generation of Skeletal Muscle Organoids from Human Pluripotent Stem Cells

댓글 달기 / BioGems, CHIR 99021, Small Molecules, WNT pathway / 글쓴이

#CHIR 99021 ;  #2520691 ;  Bio Protoc. 2024 May 5;14(9):e4984. doi: 10.21769/BioProtoc.4984. Urs Kindler 1, Holm Zaehres 1, Lampros Mavrommatis 1 2 Affiliations expand Abstract Various protocols have been proven effective in the directed differentiation of mouse and human pluripotent stem cells into skeletal muscles and used to study myogenesis. Current 2D myogenic differentiation protocols can mimic muscle development and its alteration …

Generation of Skeletal Muscle Organoids from Human Pluripotent Stem Cells 더 보기 »

ERK/MEK Pathway Regulates Th17 Cell Differentiation in Patients with Pemphigus Vulgaris

댓글 달기 / BioGems, Flow cytometry / 글쓴이

#Anti-Human CD3 SAFIRE Purified ; #Anti-Human CD28 SAFIRE Purified ;  #05121-25 ; #10311-25 ;  Indian J Dermatol. 2023 Nov-Dec;68(6):724. Kai Han 1, Song-Shan Li 1, Wen Pan 2, Mei-Nian Xu 1, Mei-Zhen Zhong 1, Wen-Jing Zhang 1, Xiao-Wen Huang 1, Kang Zeng 1 Affiliations expand Abstract Background: T helper (Th) cells are involved in the pathogenesis of pemphigus vulgaris (PV). However, the mechanism still needs more exploration. Aims: This study aimed to evaluate …

ERK/MEK Pathway Regulates Th17 Cell Differentiation in Patients with Pemphigus Vulgaris 더 보기 »

A matter of differentiation: equine enteroids as a model for the in vivo intestinal epithelium

댓글 달기 / BioGems, CHIR 99021, Small Molecules, WNT pathway / 글쓴이

#CHIR 99021 ;  #2520691 ;  Vet Res. 2024 Mar 16;55(1):30. Christina Windhaber 1, Anna Heckl 1, Georg Csukovich 2, Barbara Pratscher 2, Iwan Anton Burgener 2, Nora Biermann 3, Franziska Dengler 4 Affiliations expand Abstract Epithelial damage due to gastrointestinal disorders frequently causes severe disease in horses. To study the underlying pathophysiological processes, we aimed to establish equine jejunum and colon enteroids (eqJE, eqCE) mimicking the in vivo epithelium. …

A matter of differentiation: equine enteroids as a model for the in vivo intestinal epithelium 더 보기 »

Mesenchymal stem cells induce an immunosuppressive microenvironment in pituitary tumors

댓글 달기 / BioGems, Flow cytometry / 글쓴이

#Anti-Human CD3 Purified  ; #05131-20 ;  J Clin Endocrinol Metabc. 2024 Apr 9:dgae212.  Daniel Marrero-Rodriguez 1, Victor A Cortes-Morales 1 2, Amayrani Cano-Zaragoza 1, Florencia Martinez-Mendoza 1, Jacobo Kerbel-Suton 1, Sandra Vela-Patiño 1, Alejandra Chavez-Santoscoy 3, Silvia Hinojosa-Alvarez 3, Jesus Hernandez-Perez 3, Erick Gomez-Apo 4, Guadalupe R Fajardo-Orduña 2, Keiko Taniguchi-Ponciano 1, Juan Jose Montesinos 2, Moises Mercado 1 Affiliations expand Abstract Background: The tumor microenvironment (TME) includes diverse cellular components such as mesenchymal stem cells (MSC) and immune cells among others. MSC have been …

Mesenchymal stem cells induce an immunosuppressive microenvironment in pituitary tumors 더 보기 »

ALOX5 drives the pyroptosis of CD4+ T cells and tissue inflammation in rheumatoid arthritis

댓글 달기 / BioGems, Flow cytometry / 글쓴이

#Anti-Rat CD3 SAFIRE Purified ; #Anti-Rat CD28 SAFIRE Purified ;  #05113-25; #10313-25 ;  Sci Signal. 2024 Feb 27;17(825):eadh1178. Hao Cai 1, Jianhua Zhang 1, Hua Xu 1, Weiwei Sun 1, Weijie Wu 1, Chen Dong 2, Ping Zhou 3, Chengbin Xue 4, Yunyi Nan 1, Yingchen Ni 1, Xinyuan Wu 1, Zhifeng Gu 2, Minhao Chen 1, Youhua Wang 1 Affiliations expand Abstract Pyroptosis, an inflammatory form of programmed cell death, is linked to the pathology of rheumatoid arthritis (RA). Here, we investigated …

ALOX5 drives the pyroptosis of CD4+ T cells and tissue inflammation in rheumatoid arthritis 더 보기 »

Metabolic landscape of head and neck squamous cell carcinoma informs a novel kynurenine/Siglec-15 axis in immune escape.

댓글 달기 / Flow cytometry / 글쓴이

#Anti-Human CD3 SAFIRE Purified ; #Anti-Human CD28 SAFIRE Purified ; #Anti-Human CD279 (PD-1) PE ; #Transcription Factor Fixation/Permeabilization Concentrate ;  #05121-25 ; #10311-25 ; #31831-60 ; #92550-00 ; Cancer Commun (Lond). 2024 May 12. doi: 10.1002/cac2.12545. Epub ahead of print. Xin-Yu Zhang 1 2 3, Jian-Bo Shi 1 2 3, Shu-Fang Jin 2 3 4, Rui-Jie Wang 1 2 3, Ming-Yu Li 1 2 3, Zhi-Yuan Zhang 1 2 3, Xi Yang 1 2 3, Hai-Long Ma 1 2 3 Affiliations expand Abstract Background: Metabolic reprograming and immune …

Metabolic landscape of head and neck squamous cell carcinoma informs a novel kynurenine/Siglec-15 axis in immune escape. 더 보기 »

Substrate mechanics unveil early structural and functional pathology in iPSC micro-tissue models of hypertrophic cardiomyopathy

댓글 달기 / BioGems, CHIR 99021, ROCK inhibitor, Small Molecules, Stem cell research, WNT pathway, Y-27632 / 글쓴이

#Y-27632 ; #CHIR 99021 ; #IWP2 ; #1293823 ; #2520691 ; #6866167 ; iScience, 2024, 109954. Jingxuan Guo 1, Huanzhu Jiang 2, David Schuftan 2, Jonathan D. Moreno 4, Ghiska Ramahdita 1 3, Lavanya Aryan 2, Druv Bhagavan 2, Jonathan Silva 2, Nathaniel Huebsch 2 3 5 6 Summary Hypertension is a major cause of morbidity and mortality in patients with hypertrophic cardiomyopathy (HCM), suggesting a potential role for mechanics in HCM pathogenesis. Here, we developed an in vitro physiological model to investigate how mechanics acts together with …

Substrate mechanics unveil early structural and functional pathology in iPSC micro-tissue models of hypertrophic cardiomyopathy 더 보기 »

A Visual, In-Expensive, and Wireless Capillary Rheometer for Characterizing Wholly-Cellular Bioinks

댓글 달기 / ROCK inhibitor, Small Molecules, Y-27632 / 글쓴이

#Y-27632 ; #1293823 ; Small. 2024 Apr;20(17):e2304778. Jianyi Du 1, Stacey Lee 1, Soham Sinha 1, Fredrik S Solberg 2, Debbie L L Ho 1, Joshua P Sampson 1, Qiuling Wang 1, Tony Tam 1, Mark A Skylar-Scott 1 3 4 Affiliations expand Abstract Rheological measurements with in situ visualization can elucidate the microstructural origin of complex flow behaviors of an ink. However, existing commercial rheometers suffer from high costs, the need for dedicated facilities …

A Visual, In-Expensive, and Wireless Capillary Rheometer for Characterizing Wholly-Cellular Bioinks 더 보기 »

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