Early host immune responses in a human organoid-derived gallbladder monolayer to Salmonella Typhi strains from patients with acute and chronic infections: a comparative analysis

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Y-27632 ; 1293823 ; Front Immunol. 2024 Mar 12:15:1334762. doi: 10.3389/fimmu.2024.1334762. eCollection 2024 Rosângela Salerno-Goncalves 1, Haiyan Chen 1, Andrea C Bafford 2, Mariana Izquierdo 1, Juan Carlos Hormazábal 3, Rosanna Lagos 3, Hervé Tettelin 4, Adonis D’Mello 4, Jayaum S Booth 1, Alessio Fasano 5, Myron M Levine 1, Marcelo B Sztein 1 6 Affiliations expand Abstract Salmonella enterica serovar Typhi (S. Typhi), a human-restricted pathogen, invades the host through the gut to cause typhoid fever. Recent calculations of the …

Early host immune responses in a human organoid-derived gallbladder monolayer to Salmonella Typhi strains from patients with acute and chronic infections: a comparative analysis 더 보기 »

Three-Dimensional Cell Culture of Epididymal Basal Cells and Organoids: A Novel Tool for Toxicology

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#Y-27632 ; #1293823 ; #ROCK inhibitor ; Curr Protoc. 2024 Jan;4(1):e975. doi: 10.1002/cpz1.975. Julie Dufresne 1, Mary Gregory 1, Laurie Pinel 1, Daniel G Cyr 1 Affiliations expand Abstract Spermatozoa are formed in the testis but must transit through the epididymis to acquire motility and the ability to fertilize. The epididymis is a single convoluted tubule comprising several anatomically and physiologically distinct regions. …

Three-Dimensional Cell Culture of Epididymal Basal Cells and Organoids: A Novel Tool for Toxicology 더 보기 »

Epigenetic repression of CHCHD2 enhances survival from single cell dissociation through attenuated Rho A kinase activity

댓글 달기 / ROCK inhibitor, Small Molecules, Y-27632 / 글쓴이

#Y-27632 ; #1293823 ; Jumee Kim # 1, Eun-Ji Kwon # 1, Yun-Jeong Kim 1, Dayeon Kim 1, Yoon-Ze Shin 1, Dayeon Gil 2 3, Jung-Hyun Kim 2 3, Hyoung Doo Shin 4 5, Lyoung Hyo Kim 6, Mi-Ok Lee 7, Young-Hyun Go 8 9, Hyuk-Jin Cha 10 11 Abstract During in vitro culture, human pluripotent stem cells (hPSCs) often acquire survival advantages characterized by decreased susceptibility to mitochondrial cell death, known as “culture adaptation.” This adaptation is associated with genetic and epigenetic abnormalities, including …

Epigenetic repression of CHCHD2 enhances survival from single cell dissociation through attenuated Rho A kinase activity 더 보기 »

Endometrial organoids: a reservoir of functional mitochondria for uterine repair

댓글 달기 / ROCK inhibitor, Small Molecules, Y-27632 / 글쓴이

#Y-27632 ; #Nicotinamide ; #1293823 ; #9899208 ; Theranostics. 2024 Jan 1;14(3):954-972. doi: 10.7150/thno.90538. Sun-Young Hwang 1, Danbi Lee 1, Gaeun Lee 1, Jungho Ahn 2, Yu-Gyeong Lee 1, Hwa Seon Koo 3, Youn-Jung Kang 1 2 Abstract Background: Asherman’s syndrome (AS) is a dreadful gynecological disorder of the uterus characterized by intrauterine adhesion with severe fibrotic lesions, resulting in a damaged basalis layer with infertility. Despite extensive research on …

Endometrial organoids: a reservoir of functional mitochondria for uterine repair 더 보기 »

Abnormal developmental trajectory and vulnerability to cardiac arrhythmias in tetralogy of Fallot with DiGeorge syndrome

댓글 달기 / BioGems, ROCK inhibitor, Small Molecules, Stem cell research, Y-27632 / 글쓴이

#Y-27632 ; #1293823 ; Cells 2023, 12(18), 2319; https://doi.org/10.3390/cells12182319 Chun-Ho Chan 1, Yin-Yu Lam 1, Nicodemus Wong 1, Lin Geng 1, Jilin Zhang 2, Virpi Ahola 2, Aman Zare 2, Ronald Adolphus Li 2 3, Fredrik Lanner 4 5 6, Wendy Keung 3, Yiu-Fai Cheung 7 8 9 Affiliations expand Abstract Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. Ventricular dysfunction and cardiac arrhythmias are well-documented complications in patients with repaired TOF. Whether intrinsic abnormalities exist in TOF …

Abnormal developmental trajectory and vulnerability to cardiac arrhythmias in tetralogy of Fallot with DiGeorge syndrome 더 보기 »

Modeling of FAN1-Deficient Kidney Disease Using a Human Induced Pluripotent Stem Cell-Derived Kidney Organoid System

댓글 달기 / BioGems, ROCK inhibitor, Small Molecules, Stem cell research, Y-27632 / 글쓴이

#Y-27632 ; #1293823 ; Commun Biol. 2023 Sep 22;6(1):969. doi: 10.1038/s42003-023-05344-6. Sun Woo Lim, Dohyun Na, Hanbi Lee, Xianying Fang, Sheng Cui, Yoo Jin Shin, Kang In Lee, Jae Young Lee, Chul Woo Yang and Byung Ha Chung Abstract Karyomegalic interstitial nephritis (KIN) is a genetic kidney disease caused by mutations in the FANCD2/FANCI-Associated Nuclease …

Modeling of FAN1-Deficient Kidney Disease Using a Human Induced Pluripotent Stem Cell-Derived Kidney Organoid System 더 보기 »

Disruption of the primocolonizing microbiota alters epithelial homeostasis and imprints stem cells in the colon of neonatal piglets

댓글 달기 / BioGems, ROCK inhibitor, Small Molecules, Y-27632 / 글쓴이

#Y-27632 ; #1293823 FASEB J. 2023 Oct;37(10):e23149. doi: 10.1096/fj.202301182R. Martin Beaumont 1, Corinne Lencina 1, Katia Fève 1, Céline Barilly 1, Laurence Le-Normand 2, Sylvie Combes 1, Guillaume Devailly 1, Gaëlle Boudry 2 Affiliations expand Abstract The gut microbiota plays a key role in the postnatal development of the intestinal epithelium. However, the bacterial members of the primocolonizing microbiota driving these effects are not fully identified and the mechanisms underlying their …

Disruption of the primocolonizing microbiota alters epithelial homeostasis and imprints stem cells in the colon of neonatal piglets 더 보기 »

PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems

댓글 달기 / BioGems, ROCK inhibitor, Small Molecules, Y-27632 / 글쓴이

#Y-27632 ; #1293823 EMBO Rep. 2023 Aug 3;24(8):e56399. doi: 10.15252/embr.202256399 Felix Kraus 1 2, Ellen A Goodall 1 2, Ian R Smith 1, Yizhi Jiang 1, Julia C Paoli 1, Frank Adolf 2 3, Jiuchun Zhang 1, Joao A Paulo 1, Brenda A Schulman 2 3, J Wade Harper 1 2 Affiliations expand Free PMC article Abstract The protein kinase PINK1 and ubiquitin ligase Parkin promote removal of damaged mitochondria via a feed-forward mechanism involving ubiquitin (Ub) phosphorylation (pUb), Parkin …

PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems 더 보기 »

Network-informed discovery of multidrug combinations for ERα+/HER2-/PI3Kα-mutant breast cancer

댓글 달기 / BioGems, ROCK inhibitor, Small Molecules, Stem cell research, Y-27632 / 글쓴이

#Y-27632;  #SB 202190; #1293823;  #1523072 Cell Mol Life Sci. 2023 Mar 3;80(3):80. doi: 10.1007/s00018-023-04730-x. Dina Hany 1 2, Marloes Zoetemelk 3 4 5, Kaushik Bhattacharya 1, Patrycja Nowak-Sliwinska 3 4 5, Didier Picard 6 Affiliations expand Free PMC article Abstract Breast cancer is a persistent threat to women worldwide. A large proportion of breast cancers are dependent on the estrogen receptor α (ERα) for tumor progression. Therefore, targeting ERα with …

Network-informed discovery of multidrug combinations for ERα+/HER2-/PI3Kα-mutant breast cancer 더 보기 »

Enhanced axonal regeneration of ALS patient iPSC-derived motor neurons harboring SOD1A4V mutation

댓글 달기 / BioGems, ROCK inhibitor, Small Molecules, Y-27632 / 글쓴이

#Y-27632; #1293823 Sci Rep. 2023 Apr 5;13(1):5597. doi: 10.1038/s41598-023-31720-7. Katherine L Marshall 1, Labchan Rajbhandari 1, Arun Venkatesan 1, Nicholas J Maragakis 1, Mohamed H Farah 2 Affiliations expand Free PMC article Abstract Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, characterized by degeneration of upper and lower motor neurons that leads to muscle weakness, paralysis, and death, but the effects of disease-causing mutations …

Enhanced axonal regeneration of ALS patient iPSC-derived motor neurons harboring SOD1A4V mutation 더 보기 »

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