7월 2023 - 바이오젬스코리아

Human platelet lysate stimulates neurotrophic properties of human adipose-derived stem cells better than Schwann cell-like cells

#Forskolin; # 6652995 Stem Cell Res Ther. 2023 Jul 21;14(1):179. doi: 10.1186/s13287-023-03407-3. Stefania Brambilla # 1, Martino Guiotto # 2, Enrica Torretta 3, Ilaria Armenia 4, Matteo Moretti 1 5 6 7, Cecilia Gelfi 3 8, Silvia Palombella 9, Pietro G di Summa 2 Affiliations expand Free PMC article Abstract Background: Trauma-associated peripheral nerve injury is a widespread clinical problem causing sensory and motor disabilities. Schwann cells (SCs) contribute to nerve regeneration, mainly by secreting nerve growth factor …

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Inducible HEK293 AAV packaging cell lines expressing Rep proteins

#Recombinant Human Transferrin; #10-366 Mol Ther Methods Clin Dev. 2023,https://doi.org/10.1016/j.omtm.2023.07.002 Lovro Jalsic,1,2 Viktoria Lytvyn,2 Seyyed Mehdy Elahi,2 Sabahudin Hrapovic,3 Nasha Nassoury,2 Parminder Singh Chahal,2 Bruno Gaillet,1 and Rénald Gilbert1,2,4 Packaging or producer cell lines for scalable recombinant adeno-associated virus (rAAV) production have been notoriously difficult to create due in part to the cytostatic nature of …

Inducible HEK293 AAV packaging cell lines expressing Rep proteins 더 보기 »

The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets.

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#Forskolin ; #dorsomorphin ; # Y-27632; #6652995; #8666430; #1293832; Nat Cell Biol (2023). https://doi.org/10.1038/s41556-023-01178-w Abstract Lipid droplets (LDs) are crucial organelles for energy storage and lipid homeostasis. Autophagy of LDs is an important pathway for their catabolism, but the molecular mechanisms mediating LD degradation by selective autophagy (lipophagy) are unknown. Here we identify spartin as a …

The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets. 더 보기 »

CRL4B complex-mediated H2AK119 monoubiquitination restrains Th1 and Th2 cell differentiation.

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#Ionomycin ; #5608212 Cell Death Differ. 2023 Jun;30(6):1488-1502. doi: 10.1038/s41418-023-01155-8 Liping Qin 1, Yu Song 1, Fan Zhang 1, Ru Wang 1, Li Zhou 1, Shiqi Jin 1, Chaojia Chen 2, Chunyang Li 3, Molin Wang 1, Baichun Jiang 1, Gongping Sun 3, Chunhong Ma 2, Yaoqin Gong 4, Peishan Li 5 6 Affiliations expand Abstract CD4+ T helper (Th) cell differentiation is regulated by lineage-specific expression of transcription factors, which is tightly associated with epigenetic modifications, including histone acetylation and methylation. However, the factors regulating …

CRL4B complex-mediated H2AK119 monoubiquitination restrains Th1 and Th2 cell differentiation. 더 보기 »

Periplocin targets low density lipoprotein receptor-related protein 4 to attenuate osteoclastogenesis and protect against osteoporosis.

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#Annexin V Apoptosis Detection Kit; #62700 Biochem Pharmacol. 2023 May;211:115516. doi: 10.1016/j.bcp.2023.115516 Xiaodi Zhang 1, Zhengfang Sun 2, Ying Zhang 2, Liuzhu Pan 2, Wei Jiang 2, Hui Dong 3, Zhengxin Jin 3, Jianning Kang 2, Ronghan Liu 4, Bin Ning 5 Affiliations expand Abstract Osteoporosis is a common inflammaging-related condition, where long-term accumulation of pro-inflammatory cytokines causes massive bone loss. Periplocin, a cardiotonic steroid isolated from Periploca forrestii, has been proved to reduce inflammation …

Periplocin targets low density lipoprotein receptor-related protein 4 to attenuate osteoclastogenesis and protect against osteoporosis. 더 보기 »

Exosomes Derived From Kartogenin-Preconditioned Mesenchymal Stem Cells Promote Cartilage Formation and Collagen Maturation for Enthesis Regeneration in a Rat Model of Chronic Rotator Cuff Tear.

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#Kartogenin; #4723153 Am J Sports Med. 2023 Apr;51(5):1267-1276. doi: 10.1177/03635465231155927 Jiangyu Cai 1, Junjie Xu 1, Zipeng Ye 1, Liren Wang 1, Ting Zheng 1, Tianlun Zhang 1, Yufeng Li 1, Jia Jiang 1, Jinzhong Zhao 1 Affiliations expand Abstract Background: Poor tendon-to-bone healing in chronic rotator cuff tears (RCTs) is related to unsatisfactory outcomes. Exosomes derived from mesenchymal stem cells reportedly enhance rotator cuff healing. However, the difficulty in producing exosomes with a …

Exosomes Derived From Kartogenin-Preconditioned Mesenchymal Stem Cells Promote Cartilage Formation and Collagen Maturation for Enthesis Regeneration in a Rat Model of Chronic Rotator Cuff Tear. 더 보기 »

ACTL6A protects gastric cancer cells against ferroptosis through induction of glutathione synthesis.

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#Gastrin I ; #A83-01; #1003377; #9094360 Nat Commun. 2023 Jul 13;14(1):4193. doi: 10.1038/s41467-023-39901-8. Ziqing Yang # 1 2 3, Shaomin Zou # 1 2 3, Yijing Zhang 1 2 3, Jieping Zhang 1 2 3, Peng Zhang 1 2 3, Lishi Xiao 1 2 3, Yunling Xie 1 2 3, Manqi Meng 1 2 3, Junyan Feng 1 2 3, Liang Kang 4 5, Mong-Hong Lee 6 7 8, Lekun Fang 9 10 11 Affiliations expand Free PMC article Abstract Gastric cancer (GC), one of the most common malignant tumors in the world, exhibits a rapid metastasis rate and causes high mortality. Diagnostic markers and …

ACTL6A protects gastric cancer cells against ferroptosis through induction of glutathione synthesis. 더 보기 »

TREM2 expression promotes liver and peritoneal M2 macrophage polarization in mice infected with Schistosoma japonicum.

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#Anti-Mouse F4/80 Antigen PE; # Anti-Human/Mouse CD11b PE-Cyanine7; #02922-60; #03221-77 J Cell Mol Med. 2023 Jul 10. doi: 10.1111/jcmm.17842. Dandan Zhu 1, Min Huang 1, Pei Shen 2, Bei Zhang 1, Guo Chen 1, Jinling Chen 1, Lian Duan 1 3, Yinong Duan 1 Affiliations expand Free article Abstract Schistosomiasis is a tropical parasitic disease that damages the liver and poses a serious threat to human health. Macrophages play a key role in …

TREM2 expression promotes liver and peritoneal M2 macrophage polarization in mice infected with Schistosoma japonicum. 더 보기 »

Novel method of differentiating human induced pluripotent stem cells to mature cardiomyocytes via Sfrp2.

댓글 달기 / BioGems, extracellular matrix and substrate / 글쓴이 biogems

#BG iMatrix-511; #RL511 Ying-Chang Hsueh 1, Richard E Pratt 1, Victor J Dzau 2, Conrad P Hodgkinson 3 Affiliations expand Free PMC article Abstract Current methods to generate cardiomyocytes from induced pluripotent stem cells (iPSc) utilize broad-spectrum pharmacological inhibitors. These methods give rise to cardiomyocytes which are typically immature. Since we have recently demonstrated that cardiomyogenesis in vitro and in vivo requires Sfrp2, …

Novel method of differentiating human induced pluripotent stem cells to mature cardiomyocytes via Sfrp2. 더 보기 »

Antidepressants escitalopram and venlafaxine up-regulate BDNF promoter IV but down-regulate neurite outgrowth in differentiating SH-SY5Y neurons.

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#All-Trans Retinoic Acid, #3027949 Neurochem Int. 2023 Jul 12;105571. doi: 10.1016/j.neuint.2023.105571. Denis Zosen 1, Elena Kondratskaya 2, Oykum Kaplan-Arabaci 1, Fred Haugen 3, Ragnhild Elisabeth Paulsen 4 Affiliations expand Abstract Antidepressants are used to treat depression and some anxiety disorders, including use in pregnant patients. The pharmacological actions of these drugs generally determine the uptake and metabolism of a series of neurotransmitters, such as serotonin, …

Antidepressants escitalopram and venlafaxine up-regulate BDNF promoter IV but down-regulate neurite outgrowth in differentiating SH-SY5Y neurons. 더 보기 »