Immune index: a gene and cell prognostic signature for immunotherapy response prediction in hepatocellular carcinoma

#anti-human CD8a (RPA-T8) from BioGems; # anti-human CD56 from BioGems XiuliangCuia1LuHanbc1LongjiuCuid1GongboFuaErdongLiuaDuoweiWangeBinSongfYongxiangZhangbcWenxiaZhoubcHongyangWangaJingFua https://doi.org/10.1016/j.phrs.2022.106583 Abstract The heterogeneity of tumor immune microenvironment (TIME) plays important roles in the development and immunotherapy response of hepatocellular carcinoma (HCC). Using machine learning algorithms, we introduced the immune index (IMI), a prognostic model based on the HCC immune landscape. We found that …

Immune index: a gene and cell prognostic signature for immunotherapy response prediction in hepatocellular carcinoma 더 보기 »

Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models

#SU5402 (Biogems, 2159233) Nat Commun. 2022 Nov 17;13(1):7032. doi: 10.1038/s41467-022-34811-7. Hsueh-Fu Wu 1 2, Wenxin Yu 3, Kenyi Saito-Diaz 1, Chia-Wei Huang 2 4, Joseph Carey 5, Frances Lefcort 5, Gerald W Hart 2 4, Hong-Xiang Liu 3, Nadja Zeltner 6 7 8 Affiliations expand Free PMC article Abstract Familial dysautonomia (FD), a rare neurodevelopmental and neurodegenerative disorder affects the sympathetic and sensory nervous system. Although almost all patients harbor a mutation in ELP1, it remains unresolved exactly …

Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models 더 보기 »

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