Genetic circuit design automation for the gut resident species Bacteroides thetaiotaomicron

댓글 달기 / Small Molecules, Stem cell research / 글쓴이

Nat Biotechnol. 2020 Aug;38(8):962-969. doi: 10.1038/s41587-020-0468-5. Epub 2020 Mar 30. Mao Taketani 1 2, Jianbo Zhang 1, Shuyi Zhang 1, Alexander J Triassi 1, Yu-Ja Huang 1, Linda G Griffith 1, Christopher A Voigt 3Affiliations expand Erratum in Abstract Bacteroides thetaiotaomicron is a human-associated bacterium that holds promise for delivery of therapies in the gut microbiome1. Therapeutic bacteria would benefit from the ability to turn on different programs of gene …

Genetic circuit design automation for the gut resident species Bacteroides thetaiotaomicron 더 보기 »

Gut metabolite trimethylamine N-oxide induces aging-associated phenotype of midbrain organoids for the induced pluripotent stem cell-based modeling of late-onset disease

댓글 달기 / Small Molecules, Stem cell research / 글쓴이

# IWP2 (Biogems), #db-cAMP (Biogems) Front Aging Neurosci. 2022 Aug 16;14:925227. doi: 10.3389/fnagi.2022.925227. eCollection 2022 Youngsun Lee 1 2, Ji Su Kang 1 2, On-Ju Ham 1, Mi-Young Son 1 2, Mi-Ok Lee 1 2 Abstract Brain organoids are valuable research models for human development and disease since they mimic the various cell compositions and structures of the human brain; however, they have challenges in presenting aging phenotypes for …

Gut metabolite trimethylamine N-oxide induces aging-associated phenotype of midbrain organoids for the induced pluripotent stem cell-based modeling of late-onset disease 더 보기 »

Human Palatine Tonsils Are Linked to Alzheimer’s Disease through Function of Reservoir of Amyloid Beta Protein Associated with Bacterial Infection

댓글 달기 / Small Molecules, Stem cell research / 글쓴이

# prostaglandin E2 (3632464; BioGems) Cells. 2022 Jul 24;11(15):2285. doi: 10.3390/cells11152285. Jung Yeon Lim 1, Jung Eun Lee 2, Han Kyung Kim 3, Yeon-Joon Park 4, Jung Ho Jeon 1, Soon-A Park 5, Naeun Lee 6, Il Hwan Lee 1, Do Hyun Kim 1, Seung Ho Yang 2, Jongman Yoo 3, Sung Won Kim 1 Affiliations expand Free PMC article Abstract Amyloid-β (Aβ)-peptide production or deposition in the neuropathology of Alzheimer’s disease (AD) was shown to be caused by …

Human Palatine Tonsils Are Linked to Alzheimer’s Disease through Function of Reservoir of Amyloid Beta Protein Associated with Bacterial Infection 더 보기 »

Decoding the activated stem cell phenotype of the neonatally maturing pituitary

댓글 달기 / Small Molecules, Stem cell research / 글쓴이

# LGK-974 (Biogems) eLife. 2022; 11: e75742. Published online 2022 Jun 14. doi: 10.7554/eLife.75742 Emma Laporte 1, Florian Hermans 1 2, Silke De Vriendt 1, Annelies Vennekens 1, Diether Lambrechts 3 4, Charlotte Nys 1, Benoit Cox 1, Hugo Vankelecom 1 Affiliations expand Free PMC article Abstract The pituitary represents the endocrine master regulator. In mouse, the gland undergoes active maturation immediately after birth. Here, we in detail portrayed the stem cell compartment of neonatal pituitary. …

Decoding the activated stem cell phenotype of the neonatally maturing pituitary 더 보기 »

Controlling neural territory patterning from pluripotency using a systems developmental biology approach

댓글 달기 / CHIR 99021, Small Molecules, Stem cell research, WNT pathway / 글쓴이

#A83-01 9094360 BioGems, #LDN-193189 1066208 BioGems, #CHIR 99021 Biogems Cat# 2520691, #XAV939 Biogems Cat# 2848932 iScience. 2022 Mar 21;25(4):104133. doi: 10.1016/j.isci.2022.104133. eCollection 2022 Apr 15. Katie E Sears 1 2 3, Keerthi Gullapalli 3, Divya Trivedi 3, Alexander Mihas 2, Michael A Bukys 2 3, Jan Jensen 1 2 3 Abstract Successful manufacture of specialized human cells requires process understanding of directed differentiation. Here, we apply high-dimensional Design of Experiments (HD-DoE) …

Controlling neural territory patterning from pluripotency using a systems developmental biology approach 더 보기 »

Mutant ANP induces mitochondrial and ion channel remodeling in a human iPSC-derived atrial fibrillation model

댓글 달기 / Small Molecules, Stem cell research / 글쓴이

#dexamethasone (Biogems) JCI Insight. 2022 Apr 8;7(7):e155640. doi: 10.1172/jci.insight.155640. Olivia T Ly 1 2, Hanna Chen 1, Grace E Brown 2, Liang Hong 1, Xinge Wang 1 2, Yong Duk Han 2, Mahmud Arif Pavel 1, Arvind Sridhar 1 3, Mark Maienschein-Cline 4, Brandon Chalazan 1, Sang-Ging Ong 1 5, Khaled Abdelhady 6, Malek Massad 6, Lona Ernst Rizkallah 6, Jalees Rehman 1 2 6, Salman R Khetani 2, Dawood Darbar 1 2 3 6 Free PMC article Abstract Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) can model heritable arrhythmias to personalize therapies for individual patients. Although …

Mutant ANP induces mitochondrial and ion channel remodeling in a human iPSC-derived atrial fibrillation model 더 보기 »

Orthogonally induced differentiation of stem cells for the programmatic patterning of vascularized organoids and bioprinted tissues

댓글 달기 / CHIR 99021, Small Molecules, Stem cell research, WNT pathway / 글쓴이

#SB431542 (BioGems, 3014193) , #LDN193189 (BioGems, 1066208), #CHIR99021 (BioGems, 2520691) Nat Biomed Eng. 2022 Apr;6(4):449-462. doi: 10.1038/s41551-022-00856-8. Mark A Skylar-Scott # 1 2 3 4, Jeremy Y Huang # 5 6 7, Aric Lu # 5 6 8, Alex H M Ng 5 7, Tomoya Duenki 5 6, Songlei Liu 5 7, Lucy L Nam 5 6, Sarita Damaraju 5 6, George M Church 5 7, Jennifer A Lewis 9 10 Free PMC article Abstract The generation of organoids and tissues with programmable cellular complexity, architecture and function would benefit from …

Orthogonally induced differentiation of stem cells for the programmatic patterning of vascularized organoids and bioprinted tissues 더 보기 »

A protocol to differentiate nociceptors, mechanoreceptors, and proprioceptors from human pluripotent stem cells

댓글 달기 / ROCK inhibitor, Small Molecules, Stem cell research, Y-27632 / 글쓴이

#SU5402 Biogems Cat## 2159233, #Y-27632 Biogems Cat# #1293823 STAR Protoc. 2022 Mar 18;3(2):101187. doi: 10.1016/j.xpro.2022.101187. eCollection 2022 Jun 17. Kenyi Saito-Diaz 1, Nadja Zeltner 1 2 3 Abstract Human pluripotent stem cells (hPSCs) show promise for studying diseases affecting cell populations that are not easily available, including sensory neurons (SNs). Here, we present a differentiation protocol in chemically defined conditions …

A protocol to differentiate nociceptors, mechanoreceptors, and proprioceptors from human pluripotent stem cells 더 보기 »

Optogenetic Control of Engrafted Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Live Mice: A Proof-of-Concept Study

댓글 달기 / CHIR 99021, Small Molecules, Stem cell research, WNT pathway / 글쓴이

# CHIR99021 (Biogems, #2520691), #  IWR1 (Biogems, #1128234) Cells. 2022 Mar 10;11(6):951. doi: 10.3390/cells11060951. Jyotsna Joshi 1, Bing Xu 1 2, Michael Rubart 3, Yun Chang 4, Xiaoping Bao 4, Hari P Chaliki 1, Luis R Scott 1, Wuqiang Zhu 1 5 6 Abstract Background: Cellular transplantation has emerged as promising approach for treating cardiac diseases. However, a poor engraftment rate limits our understanding on how transplanted cardiomyocytes contribute to cardiac function in the …

Optogenetic Control of Engrafted Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Live Mice: A Proof-of-Concept Study 더 보기 »

Generation of individualized immunocompatible endothelial cells from HLA-I-matched human pluripotent stem cells

댓글 달기 / Small Molecules, Stem cell research / 글쓴이

#PMA (phorbol 12-myristate-13-acetate) (Biogems, 1652981) # ionomycin (Biogems, 5608212) Stem Cell Res Ther. 2022 Feb 2;13(1):48. doi: 10.1186/s13287-022-02720-7. Chanchan Song # 1, Linli Wang # 2 3, Qingyang Li 1, Baoyi Liao 1, Weihua Qiao 4, Qiang Li 2 3, Nianguo Dong 5, Liangping Li 6 Affiliations expand Free PMC article Erratum in Abstract Background: Endothelial cells (ECs) derived from human-induced pluripotent stem cell (iPSC) are a valuable cell resource for cardiovascular regeneration. To avoid time-consuming …

Generation of individualized immunocompatible endothelial cells from HLA-I-matched human pluripotent stem cells 더 보기 »

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