In vitro and in vivo models define a molecular signature reference for human embryonic notochordal cells

댓글 달기 / ROCK inhibitor, Small Molecules, Y-27632 / 글쓴이

#Y-27632 ; #1293823 ; iScience,Volume 27, Issue 2, 2024,109018. Julie Warin 19, Nicolas Vedrenne 189, Vivian Tam 2, Mengxia Zhu 2, Danqing Yin 23, Xinyi Lin 23, Bluwen Guidoux-D’halluin 1, Antoine Humeau 8, Luce Roseiro 1, Lily Paillat 1, Claire Chédeville 1, Caroline Chariau 4, Frank Riemers 5, Markus Templin 6, Jérôme Guicheux 1, Marianna A. Tryfonidou 5, Joshua W.K. Ho 23, Laurent David 47, Danny Chan 2, Anne Camus 110 Summary Understanding the emergence of human notochordal cells (NC) is essential for the development of regenerative approaches. We present a comprehensive investigation into the specification and generation of bona fide NC using a straightforward pluripotent stem cell (PSC)-based system benchmarked with human fetal notochord. By …

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Peptide-Guided Nanoparticle Drug Delivery for Cardiomyocytes

댓글 달기 / CHIR 99021, Small Molecules, WNT pathway / 글쓴이

#CHIR 99021 ; #IWR1 ; #2520691 ;  #1128234 ; Biology 2024, 13(1), 47 Dong Li 1, Austin Taylor 2, Haiwang Shi 1, Fang Zhou 2, Pengsheng Li 1, Jyotsna Joshi 1, Wuqiang Zhu 1, Shu Wang 2 Affiliations expand Abstract Background: Nanoparticles (NPs) have been extensively utilized as a drug delivery system to control the release of therapeutic agents to treat cardiac injuries. However, despite the advantages of utilizing NP-based drug delivery …

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Postnatal development of mouse spermatogonial stem cells as determined by immunophenotype, regenerative capacity, and long-term culture-initiating ability: a model for practical applications

댓글 달기 / Buffers and Solutions, viability dye 780 / 글쓴이

#Viability dye 506 ;  #62210-00 ;  Sci Rep. 2024 Jan 27;14(1):2299. doi: 10.1038/s41598-024-52824-8. Youngmin Song 1, Xiangfan Zhang 1, Joëlle A Desmarais 1 2, Makoto Nagano 3 Affiliations expand Abstract Spermatogonial stem cells (SSCs) are the foundation of life-long spermatogenesis. While SSC research has advanced greatly over the past two decades, characterization of SSCs during postnatal development has not been well documented. Using the …

Postnatal development of mouse spermatogonial stem cells as determined by immunophenotype, regenerative capacity, and long-term culture-initiating ability: a model for practical applications 더 보기 »

Optimized and Scalable Precoating-Free Reprogramming of Human Peripheral Blood Mononuclear Cells into iPSCs

댓글 달기 / extracellular matrix and substrate, Stem cell research / 글쓴이

#BG iMatrix-511 Silk ;  #RL511S ; #ECM ; Curr Protoc. 2024 Jan;4(1):e979. doi: 10.1002/cpz1.979. Elisabetta Fiacco 1, Sara Landi 1, Jacopo Zasso 1, Chiara Ambrosini 1, Giovanni Faga 1 Affiliations expand Abstract Human disease modeling has been profoundly transformed by the introduction of human induced pluripotent stem cells (iPSCs), marking the onset of a new era. This ground-breaking development offers a tailored framework for generating …

Optimized and Scalable Precoating-Free Reprogramming of Human Peripheral Blood Mononuclear Cells into iPSCs 더 보기 »

Three-Dimensional Cell Culture of Epididymal Basal Cells and Organoids: A Novel Tool for Toxicology

댓글 달기 / ROCK inhibitor, Small Molecules, Y-27632 / 글쓴이

#Y-27632 ; #1293823 ; #ROCK inhibitor ; Curr Protoc. 2024 Jan;4(1):e975. doi: 10.1002/cpz1.975. Julie Dufresne 1, Mary Gregory 1, Laurie Pinel 1, Daniel G Cyr 1 Affiliations expand Abstract Spermatozoa are formed in the testis but must transit through the epididymis to acquire motility and the ability to fertilize. The epididymis is a single convoluted tubule comprising several anatomically and physiologically distinct regions. …

Three-Dimensional Cell Culture of Epididymal Basal Cells and Organoids: A Novel Tool for Toxicology 더 보기 »

Tumor cell senescence-induced macrophage CD73 expression is a critical metabolic immune checkpoint in the aging tumor microenvironment

댓글 달기 / Small Molecules / 글쓴이

# Ionomycin Calcium Salt ;  #5608212 ;  *** BioGems 제품이나 Peprotech 으로 표기 Theranostics. 2024 Jan 20;14(3):1224-1240. Yue Deng 1 2 3, Qinyan Chen 1 2 3, Xiao Yang 1 2 3, Yajie Sun 1 2 3, Bin Zhang 1 2 3, Wenwen Wei 1 2 3, Suke Deng 1 2 3, Jingshu Meng 1 2 3, Yan Hu 1 2 3, Yijun Wang 1 2 3, Zhanjie Zhang 1 2 3, Lu Wen 1 2 3, Fang Huang 1 2 3, Chao Wan 1 2 3, Kunyu Yang 1 2 3 Affiliations expand Abstract Background: The role of senescent cells in the tumor microenvironment (TME) is usually bilateral, and diverse therapeutic approaches, such as radiotherapy and …

Tumor cell senescence-induced macrophage CD73 expression is a critical metabolic immune checkpoint in the aging tumor microenvironment 더 보기 »

Reduction of Activin A gives rise to comparable expression of key definitive endoderm and mature beta cell markers

댓글 달기 / CHIR 99021, Small Molecules, WNT pathway / 글쓴이

#CHIR99021 ;  #2520691 ;  *** BioGems 제품이나 Peprotech 으로 표기 Regen Med. 2024 Jan;19(1):47-63.  Aldyn Wildey 1, Stephen Harrington 1, Lisa Stehno-Bittel 1 2, Francis Karanu 1 Affiliations expand Abstract Aim: Cell therapies for diabetes rely on differentiation of stem cells into insulin-producing cells, which is complex and expensive. Our goal was to evaluate production costs and test ways to reduce it. Methods: Cost of Goods (COGs) …

Reduction of Activin A gives rise to comparable expression of key definitive endoderm and mature beta cell markers 더 보기 »

Regulated intestinal microbiota and gut immunity to ameliorate type 1 diabetes mellitus: A novel mechanism for stem cell-based therapy

댓글 달기 / BioGems, Small Molecules / 글쓴이

#Phorbol 12-myristate 13-acetate (PMA) ; #Ionomycin Calcium Salt ; #Brefeldin A; #1652981 ; #5608212 ; #2031560 ; Biomed Pharmacother. 2024 Jan:170:116033. Shu-Juan Zheng 1, Yi Luo 2, Jian-Bin Wang 2, Xue-Mei Chen 3, Yan Xu 2, Jian-Hui Xiao 4 Affiliations expand Free article Abstract Although stem cell transplantation is an effective strategy in the treatment of type 1 diabetes mellitus (T1DM), the mechanisms underlying its therapeutic effects …

Regulated intestinal microbiota and gut immunity to ameliorate type 1 diabetes mellitus: A novel mechanism for stem cell-based therapy 더 보기 »

Engineered cocultures of iPSC-derived atrial cardiomyocytes and atrial fibroblasts for modeling atrial fibrillation

댓글 달기 / Small Molecules / 글쓴이

#Dexamethasone ; #5000222 ; Sci Adv. 2024 Jan 19;10(3):eadg1222. doi: 10.1126/sciadv.adg1222. Grace E Brown 1, Yong Duk Han 1, Ashlin R Michell 1, Olivia T Ly 1 2, Carlos G Vanoye 3, Emanuele Spanghero 1, Alfred L George Jr 3, Dawood Darbar 1 2 4 5, Salman R Khetani 1 Abstract Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia treatable with antiarrhythmic drugs; however, patient responses remain highly variable. Human induced pluripotent stem cell-derived …

Engineered cocultures of iPSC-derived atrial cardiomyocytes and atrial fibroblasts for modeling atrial fibrillation 더 보기 »

Development of Polarity-Reversed Endometrial Epithelial Organoids

댓글 달기 / ROCK inhibitor, Small Molecules, Y-27632 / 글쓴이

#Y-27632 ; #1293823 ; Reproduction. 2024 Jan 1;167(3):e230478. Vakil Ahmad 1, Sai Goutham Reddy Yeddula 2, Bhanu Telugu 3, Thomas E Spencer 4, Andrew M Kelleher 5 Affiliations expand Abstract The uterine epithelium is composed of a single layer of hormone responsive polarized epithelial cells that line the lumen and form tubular glands. Endometrial epithelial organoids (EEO) can be generated from uterine epithelia and recapitulate …

Development of Polarity-Reversed Endometrial Epithelial Organoids 더 보기 »

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