# Y-27632 dihydrochloride (BioGems 1293823) Xianying Fang a1, Ji Hyun Kim b1, Sheng Cui a, Yoo Jin Shin a, Hanbi Lee b, Eun Jeong Ko b, Hae Il Cheong c, Sejoong Kim d, Hoon Seok Kim e, Myungshin Kim e, Chul Woo Yang af, Sun Woo Lim a1, Byung Ha Chung af1 Abstract Dent disease, an X-linked tubular disorder, is a rare condition that leads to low-molecular-weight proteinuria, hypercalciuria, kidney stones, and chronic kidney disease. Here, we successfully established a human induced pluripotent stem cells (hiPSC) line from peripheral blood mononuclear cells of …

Generation of a human induced pluripotent stem cell line from a patient with dent disease 더 보기 »

# Y-27632 dihydrochloride (BioGems 1293823) Cell Death Dis. 2023 Jan 11;14(1):15. doi: 10.1038/s41419-022-05525-x. Xiaorui Xie # 1 2, Xuebo Tong # 3, Zhihong Li 2, Quan Cheng 2, Xiaowei Wang 2, Yin Long 4, Fangbo Liu 2, Yonghui Wang 5, Juan Wang 6, Li Liu 7 Abstract Skin infections caused by drug-resistant Staphylococcus aureus occur at high rates nationwide. Mouse primary epidermal organoids (mPEOs) possess stratified histological and morphological characteristics of epidermis and are highly similar to …

Use of mouse primary epidermal organoids for USA300 infection modeling and drug screening 더 보기 »

# Y-27632 dihydrochloride (BioGems 1293823) J Transl Med. 2023 Feb 22;21(1):138. doi: 10.1186/s12967-023-03992-0 Sheng Cui 1, Xianying Fang 1, Hanbi Lee 1 2, Yoo Jin Shin 1, Eun-Sil Koh 3, Sungjin Chung 3, Hoon Suk Park 4, Sun Woo Lim 1, Kang In Lee 5, Jae Young Lee 5, Chul Woo Yang 1 2, Byung Ha Chung 6 7 Abstract Objectives: To explore the possibility of kidney organoids generated using patient derived human induced pluripotent stem cells (hiPSC) for modeling of Fabry …

Modeling of Fabry disease nephropathy using patient derived human induced pluripotent stem cells and kidney organoid system 더 보기 »

# Y-27632 dihydrochloride (BioGems 1293823) Int J Mol Sci. 2023 Feb 3;24(3):3019. doi: 10.3390/ijms24033019. Sun Woo Lim 1, Xianying Fang 1, Sheng Cui 1, Hanbi Lee 1 2, Yoo Jin Shin 1, Eun Jeong Ko 1 2, Kang In Lee 3, Jae Young Lee 3, Byung Ha Chung 1 2, Chul Woo Yang 1 2 Abstract The aim of this study is to explore the possibility of modeling Gitelman’s disease (GIT) with human-induced pluripotent stem cell (hiPSC)-derived kidney …

CRISPR-Cas9-Mediated Correction of SLC12A3 Gene Mutation Rescues the Gitelman’s Disease Phenotype in a Patient-Derived Kidney Organoid System 더 보기 »

# Y-27632 dihydrochloride (BioGems 21293823) Front Oncol. 2023 Feb 10;13:1070485. doi: 10.3389/fonc.2023.1070485. eCollection 2023. Lennox Chitsike 1, Antonella Bertucci 2, Marcelo Vazquez 1 2, Steve Lee 3, Juli J Unternaehrer 4, Penelope J Duerksen-Hughes 1 Abstract Introduction: Treatment-related toxicity following either chemo- or radiotherapy can create significant clinical challenges for HNSCC cancer patients, particularly those with HPV-associated oropharyngeal squamous cell carcinoma. Identifying and characterizing targeted therapy agents that …

GA-OH enhances the cytotoxicity of photon and proton radiation in HPV⁺ HNSCC cells 더 보기 »