PD-1 Inhibitor Aggravate Irradiation-Induced Myocardial Fibrosis by Regulating TGF-β1/Smads Signaling Pathway via GSDMD-Mediated Pyroptosis

댓글 달기 / Flow cytometry / 글쓴이

#CD45, CD3, CD4, and CD8 + antibodies were purchased from BioGems  International ; Inflammation. 2024 May 21. doi: 10.1007/s10753-024-02056-9.  Bibo Wu # 1 2 3, Shasha Zhao # 1 2 3, Jing Zhang # 1 2 3, Yao Liu # 1 2 3, Jie Bai 1 2 3, Gang Wang 1 2 3, Yu Wang 1 2 3, Han Jiang 1 2 3, Yinxiang Hu 1 2 3, Weiwei OuYang 1 2 3, Bing Lu 1 2 3, Shengfa Su 4 5 6 Affiliations expand Abstract Cancer therapy has entered a new era with the use of programmed cell death protein 1 (PD-1) immune checkpoint inhibitors. When …

PD-1 Inhibitor Aggravate Irradiation-Induced Myocardial Fibrosis by Regulating TGF-β1/Smads Signaling Pathway via GSDMD-Mediated Pyroptosis 더 보기 »

Generation of mouse and rat xenogeneic ovaries in vitro for production of mouse oocyte

댓글 달기 / ROCK inhibitor, Small Molecules, Y-27632 / 글쓴이

#Y-27632 ; #1293823 ; Anim Cells Syst (Seoul). 2024 Jun 11;28(1):303-314 Si Won Jang 1, Ye Rim Kim 2, Jae Ho Han 1, Hoon Jang 3, Hyun Woo Choi 1 2 Affiliations expand Abstract The system forming ovarian follicles is developed to investigate in vitro folliculogenesis in a confined environment to obtain functional oocytes. Several studies have reported the successful generation of fully functional oocytes using mouse-induced pluripotent …

Generation of mouse and rat xenogeneic ovaries in vitro for production of mouse oocyte 더 보기 »

Integrin activating molecule-talin1 promotes skin fibrosis in systemic sclerosis

댓글 달기 / Annexin V Apoptosis Detectino Kit, Buffers and Solutions, Flow cytometry / 글쓴이

#Annexin V apoptosis detection kit ; #62700 ; Front Immunol. 2024 May 28:15:1400819. doi: 10.3389/fimmu.2024.1400819. eCollection 2024. Dan Xu # 1, Xiandun Yuan # 1, Zhaohua Li 1, Rong Mu 1 Affiliations expand Abstract Background: Integrin-dependent cell adhesion and migration play important roles in systemic sclerosis (SSc). The roles of integrin activating molecules including talins and kindlins, however, are unclear in SSc. Objectives: We aimed to explore …

Integrin activating molecule-talin1 promotes skin fibrosis in systemic sclerosis 더 보기 »

CLN-617 retains IL-2 and IL-12 in injected tumors to drive robust and systemic immune-mediated antitumor activity

댓글 달기 / 10X RBC Lysis Buffer, Buffers and Solutions / 글쓴이

# 10X RBC Lysis Buffer ;  # 64010-00 ;  Cancer Immunol Res. 2024 Jun 6. doi: 10.1158/2326-6066.CIR-23-0636. Online ahead of print. Naveen K Mehta 1, Kavya Rakhra 1, Kristan A Meetze 1, Bochong Li 1, Noor Momin 2, Jason Yh Chang 1, K Dane Wittrup 3, Patrick A Baeuerle 4, Jennifer S Michaelson 1 Affiliations expand Abstract Despite clinical evidence of antitumor activity, the development of cytokine therapies has been hampered by a …

CLN-617 retains IL-2 and IL-12 in injected tumors to drive robust and systemic immune-mediated antitumor activity 더 보기 »

Tobacco-induced hyperglycemia promotes lung cancer progression via cancer cell-macrophage interaction through paracrine IGF2/IR/NPM1-driven PD-L1 expression

댓글 달기 / 10X RBC Lysis Buffer, Buffers and Solutions / 글쓴이

# 10X RBC Lysis Buffer ;  # 64010-00 ;  Nat Commun. 2024 Jun 8;15(1):4909. doi: 10.1038/s41467-024-49199-9. Hyun-Ji Jang # 1, Hye-Young Min # 1 2, Yun Pyo Kang 3, Hye-Jin Boo 1 4, Jisung Kim 1, Jee Hwan Ahn 1 5, Seung Ho Oh 3, Jin Hwa Jung 6, Choon-Sik Park 7, Jong-Sook Park 7, Seog-Young Kim 6 8, Ho-Young Lee 9 10 11 Affiliations expand Abstract Tobacco smoking (TS) is implicated in lung cancer (LC) progression through the development of metabolic syndrome. However, direct evidence linking …

Tobacco-induced hyperglycemia promotes lung cancer progression via cancer cell-macrophage interaction through paracrine IGF2/IR/NPM1-driven PD-L1 expression 더 보기 »

Guidelines for Manufacturing and Application of Organoids: Brain

댓글 달기 / CHIR 99021, ROCK inhibitor, Small Molecules, WNT pathway, Y-27632 / 글쓴이

#Y-27632 ;  #CHIR 99021 ;  #1293823 ;  #2520691 ;  Int J Stem Cells. 2024 May 30;17(2):158-181. Taehwan Kwak 1, Si-Hyung Park 2, Siyoung Lee 1, Yujeong Shin 1, Ki-Jun Yoon 3 4, Seung-Woo Cho 4 5, Jong-Chan Park 4 6, Seung-Ho Yang 4 7, Heeyeong Cho 4 8, Heh-In Im 4 9, Sun-Ju Ahn 4 6, Woong Sun 2 4, Ji Hun Yang 1 4 Affiliations expand Abstract This study offers a comprehensive overview of brain organoids for researchers. It combines expert opinions with technical summaries on organoid definitions, characteristics, …

Guidelines for Manufacturing and Application of Organoids: Brain 더 보기 »

Guidelines for Manufacturing and Application of Organoids: Skin

댓글 달기 / ROCK inhibitor, Small Molecules, Y-27632 / 글쓴이

#Y-27632 ; #1293823 ; Int J Stem Cells. 2024 May 30;17(2):182-193. Seunghee Lee 1 2, Yeri Alice Rim 3 4, Juryun Kim 5, Su Hyon Lee 1 6, Hye Jung Park 1 7, Hyounwoo Kim 7, Sun-Ju Ahn 1 8 9, Ji Hyeon Ju 1 3 4 5 10 Affiliations expand Abstract To address the limitations of animal testing, scientific research is increasingly focused on developing alternative testing methods. These alternative tests utilize cells or tissues derived from animals or humans …

Guidelines for Manufacturing and Application of Organoids: Skin 더 보기 »

Mesenchymal stromal cells ameliorate mitochondrial dysfunction in α cells and hyperglucagonemia in type 2 diabetes via SIRT1/FoxO3a signaling

댓글 달기 / Flow cytometry / 글쓴이

#Anti-Human CD105 (Endoglin) APC ;  #Anti-Human CD73 PE ;  #17111-80 ; #05811-60 ;  Stem Cells Transl Med. 2024 Jun 12:szae038.  Jia Song 1, Lingshu Wang 1, Liming Wang 1, Xinghong Guo 1, Qin He 1, Chen Cui 1, Huiqing Hu 1, Nan Zang 1, Mengmeng Yang 1, Fei Yan 1, Kai Liang 1, Chuan Wang 1, Fuqiang Liu 1, Yujing Sun 1, Zheng Sun 1, Hong Lai 1 2 3 4, Xinguo Hou 1 2 3 4, Li Chen 1 2 3 4 Affiliations expand Free article Abstract Dysregulation of α cells results in hyperglycemia and hyperglucagonemia in type 2 …

Mesenchymal stromal cells ameliorate mitochondrial dysfunction in α cells and hyperglucagonemia in type 2 diabetes via SIRT1/FoxO3a signaling 더 보기 »

Transcription Factor-Mediated Generation of Dopaminergic Neurons from Human iPSCs—A Comparison of Methods

댓글 달기 / Small Molecules / 글쓴이

#DAPT ; #L-Ascorbic Acid  ;  #2088055 ; #5088177 ;  *** BioGems 제품이나 Peprotech 으로 표기 Cells 2024, 13(12), 1016. McDonald KO , Lyons NM , Schoderboeck L , Hughes SM , Basak I Abstract Dopaminergic neurons are the predominant brain cells affected in Parkinson’s disease. With the limited availability of live human brain dopaminergic neurons …

Transcription Factor-Mediated Generation of Dopaminergic Neurons from Human iPSCs—A Comparison of Methods 더 보기 »

Blockage of L2HGDH-mediated S-2HG catabolism orchestrates macrophage polarization to elicit antitumor immunity

댓글 달기 / Flow cytometry / 글쓴이

#Anti-Mouse CD3e SAFIRE Purified ; #Anti-Mouse CD28 SAFIRE Purified ;  #05122-25 ; #10312-25 ;  Cell Rep. 2024 Jun 2;43(6):114300. Shuang Feng 1, Duowei Wang 1, Yanyan Jin 2, Shi Huang 3, Tong Liang 2, Wei Sun 3, Xiuli Du 2, Luoyi Zhuo 3, Chun Shan 3, Wenbo Zhang 2, Tian Jing 4, Sen Zhao 2, Ruisi Hong 2, Linjun You 2, Guilai Liu 2, Leilei Chen 5, Dan Ye 6, Xianjing Li 7, Yong Yang 8 Affiliations expand Free article Abstract The high infiltration of tumor-associated macrophages (TAMs) in the immunosuppressive tumor microenvironment …

Blockage of L2HGDH-mediated S-2HG catabolism orchestrates macrophage polarization to elicit antitumor immunity 더 보기 »

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