Lysine Methyltransferase 9 (KMT9) Is an Actionable Target in Muscle-Invasive Bladder Cancer

#A 83-01 ;  #9094360 ; **** BioGems 제품이나 Peprotech 으로 표기 Cancers (Basel). 2024 Apr 17;16(8):1532. Sainab Totonji 1, Anna Ramos-Triguero 1, Dominica Willmann 1, Manuela Sum 1, Sylvia Urban 1, Helena Bauer 1, Astrid Rieder 1, Sheng Wang 1, Holger Greschik 1, Eric Metzger 1 2, Roland Schüle 1 2 3 Affiliations expand Abstract Novel treatment modalities are imperative for the challenging management of muscle-invasive and metastatic BC to improve patient survival rates. The recently identified KMT9, an obligate …

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Hybrid Endometrial-Derived Hydrogels: Human Organoid Culture Models and In Vivo Perspectives

#A 83-01 ;  #9094360 ; *** BioGems 제품이나 Peprotech 으로 표기 Adv Healthc Mater. 2024 Apr;13(11):e2303838. María Gómez-Álvarez 1, Clara Bueno-Fernandez 1 2, Adolfo Rodríguez-Eguren 1, Emilio Francés-Herrero 1 2, Marcos Agustina-Hernández 1, Amparo Faus 1, Fernando Gisbert Roca 3, Cristina Martínez-Ramos 3 4, Amparo Galán 5 6, Antonio Pellicer 7, Hortensia Ferrero 1, Irene Cervelló 1 Affiliations expand Abstract The endometrium plays a vital role in fertility, providing a receptive environment for embryo implantation and development. Understanding the endometrial physiology is essential …

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Single-cell transcriptomics reveals cell atlas and identifies cycling tumor cells responsible for recurrence in ameloblastoma

#A 83-01 ;  #9094360 ; *** BioGems 제품이나 Peprotech 으로 표기 Int J Oral Sci. 2024 Feb 29;16(1):21.  Gan Xiong # 1 2 3, Nan Xie # 1 2 3, Min Nie 4, Rongsong Ling 5, Bokai Yun 1 2 3, Jiaxiang Xie 1 2 3, Linlin Ren 1 2 3, Yaqi Huang 1 2 3, Wenjin Wang 1 2 3, Chen Yi 1 2 3, Ming Zhang 1 2 3, Xiuyun Xu 1 2 3, Caihua Zhang 6, Bin Zou 7, Leitao Zhang 8, Xiqiang Liu 8, Hongzhang Huang 1 2 3, Demeng Chen 6, Wei Cao 9 10, Cheng Wang 11 12 13 Affiliations expand Abstract Ameloblastoma is a benign tumor characterized by locally invasive phenotypes, leading to facial bone …

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Deep Learning-Based 3D Single-Cell Imaging Analysis Pipeline Enables Quantification of Cell-Cell Interaction Dynamics in the Tumor Microenvironment

#A 83-01 ;  #9094360 ; **** BioGems 제품이나 Peprotech 으로 표기 Cancer Res. 2024 Feb 15;84(4):517-526.  Bodong Liu # 1, Yanting Zhu # 1 2, Zhenye Yang 3, Helen H N Yan 4, Suet Yi Leung 4, Jue Shi 1 2 Affiliations expand Abstract The three-dimensional (3D) tumor microenvironment (TME) comprises multiple interacting cell types that critically impact tumor pathology and therapeutic response. Efficient 3D imaging assays and analysis tools could …

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The effector program of human CD8 T cells supports tissue remodeling

#A 83-01 ;  #9094360 ; J Exp Med. 2024 Feb 5;221(2):e20230488. doi: 10.1084/jem.20230488. Michael Delacher # 1 2 3 4, Lisa Schmidleithner # 1 2, Malte Simon # 1 5 6, Philipp Stüve # 1 2, Lieke Sanderink 1 2, Agnes Hotz-Wagenblatt 7, Marina Wuttke 1 2, Kathrin Schambeck 1 2, Brigitte Ruhland 1 2, Veronika Hofmann 1 2, Sebastian Bittner 1 2, Uwe Ritter 1 2, Asmita Pant 1 2, Sara Salome Helbich 3 4, Morten Voss 3 4, Niels A Lemmermann 4 8 9, Lisa Bessiri-Schake 3 4, Toszka Bohn 3 4, Andreas Eigenberger 10, Ayse Nur Menevse 1 11, Claudia Gebhard 1, Nicholas Strieder 1, Hinrich Abken 1 12, Michael Rehli 1 13, Jochen Huehn 14 15 16, Philipp Beckhove 1 11 13, Thomas Hehlgans 1 2, Henrik Junger 17, Edward K Geissler 17, Lukas Prantl 10, Jens M Werner 17, Christian Schmidl 1, Benedikt Brors 5 18 6 19 20, Charles D Imbusch 3 4 6, Markus Feuerer 1 2 …

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3D-cultured blastoids model human embryogenesis from pre-implantation to early gastrulation stages

#A 83-01 ;  #9094360 ; Cell Stem Cell. 2023 Sep 7;30(9):1148-1165.e7. doi: 10.1016/j.stem.2023.08.005. Rowan M Karvas 1, Joseph E Zemke 1, Syed Shahzaib Ali 2, Eric Upton 1, Eshan Sane 1, Laura A Fischer 1, Chen Dong 1, Kyoung-Mi Park 1, Fei Wang 3, Kibeom Park 3, Senyue Hao 3, Brian Chew 1, Brittany Meyer 1, Chao Zhou 3, Sabine Dietmann 4, Thorold W Theunissen 5 Abstract Naive human pluripotent stem cells have the remarkable ability to self-organize into blastocyst-like structures (“blastoids”) that model lineage segregation …

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Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk

#A 83-01 ;  #9094360 ; Med. 2023 Aug 11;4(8):554-579.e9. doi: 10.1016/j.medj.2023.07.004. Juan S Gnecco 1, Alexander Brown 2, Kira Buttrey 3, Clara Ives 2, Brittany A Goods 4, Lauren Baugh 2, Victor Hernandez-Gordillo 3, Megan Loring 5, Keith B Isaacson 5, Linda G Griffith 6 Affiliations expand Abstract Background: The human endometrium undergoes recurring cycles of growth, differentiation, and breakdown in response to sex hormones. Dysregulation of epithelial-stromal communication during hormone-mediated signaling may be linked to …

Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk 더 보기 »

Single-cell transcriptomic analysis uncovers the origin and intratumoral heterogeneity of parotid pleomorphic adenoma

#A 83-01 ;  #9094360 ; Int J Oral Sci. 2023 Sep 7;15(1):38. doi: 10.1038/s41368-023-00243-2. Xiuyun Xu # 1 2 3, Jiaxiang Xie # 1 2 3, Rongsong Ling 4, Shengqi Ouyang 1 2 3, Gan Xiong 1 2 3, Yanwen Lu 1 2 3, Bokai Yun 1 2 3, Ming Zhang 1 2 3, Wenjin Wang 1 2 3, Xiqiang Liu 5, Demeng Chen 6, Cheng Wang 7 8 9 Affiliations expand Free PMC article Abstract Pleomorphic adenoma (PA) is the most common benign tumour in the salivary gland and has high morphological complexity. However, the origin and intratumoral …

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Matrigel-based organoid culture of malignant mesothelioma reproduces cisplatin sensitivity through CTR1

#A 83-01; #9094360 BMC Cancer. 2023 May 31;23(1):487. doi: 10.1186/s12885-023-10966-4. Fumiya Ito # 1, Katsuhiro Kato # 2, Izumi Yanatori 3, Yuki Maeda 1, Toyoaki Murohara 2, Shinya Toyokuni 4 5 Affiliations expand Free PMC article Abstract Organoids are a three-dimensional (3D) culture system that simulate actual organs. Therefore, tumor organoids are expected to predict precise response to chemotherapy in patients. However, to date, few studies have studied the drug …

Matrigel-based organoid culture of malignant mesothelioma reproduces cisplatin sensitivity through CTR1 더 보기 »

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