Crosstalk between Nutrition, Insulin, Juvenile Hormone, and Ecdysteroid Signaling in the Classical Insect Model, Rhodnius prolixus.

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#LY294002,  #1543664 Int J Mol Sci . 2022 Dec 20;24(1):7. doi: 10.3390/ijms24010007. Jimena Leyria 1, Samiha Benrabaa 1, Marcela Nouzova 2, Fernando G Noriega 3 4, Lilian Valadares Tose 5, Francisco Fernandez-Lima 5, Ian Orchard 1, Angela B Lange 1 Abstract The rigorous balance of endocrine signals that control insect reproductive physiology is crucial for the success of egg production. Rhodnius prolixus, a blood-feeding insect and main vector of Chagas disease, has …

Crosstalk between Nutrition, Insulin, Juvenile Hormone, and Ecdysteroid Signaling in the Classical Insect Model, Rhodnius prolixus. 더 보기 »

Insulin signaling alters antioxidant capacity in the diabetic heart

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Redox Biol. 2021 Nov;47:102140. doi: 10.1016/j.redox.2021.102140. Epub 2021 Sep 20. Satoshi Matsuzaki 1, Craig Eyster 1, Maria F Newhardt 2, Jennifer R Giorgione 1, Caroline Kinter 1, Zachary T Young 1, Michael Kinter 1, Kenneth M Humphries 3 PMID: 34560411 PMCID: PMC8473541 DOI: 10.1016/j.redox.2021.102140 Abstract Diabetic cardiomyopathy is associated with an increase in oxidative stress. However, antioxidant therapy has shown a limited capacity to mitigate disease pathology. The molecular mechanisms responsible for the …

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The involvement of insulin/ToR signaling pathway in reproductive performance of Rhodnius prolixus

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Insect Biochem Mol Biol. 2021 Mar;130:103526. doi: 10.1016/j.ibmb.2021.103526. Epub 2021 Jan 13. Jimena Leyria 1, Ian Orchard 2, Angela B Lange 3 PMID: 33453353 DOI: 10.1016/j.ibmb.2021.103526 Abstract Insulins are peptide hormones widely studied for their important regulatory roles in metabolism, growth and development. In insects, insulin signaling along with the target of rapamycin (ToR) are involved in detecting and interpreting nutrient levels. …

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Eosinophil cytolysis on Immunoglobulin G is associated with microtubule formation and suppression of rho-associated protein kinase signalling

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Clin Exp Allergy. 2020 Feb;50(2):198-212. doi: 10.1111/cea.13538. Epub 2019 Dec 9. Stephane Esnault 1, Jonathan P Leet 1, Mats W Johansson 2, Karina T Barretto 2, Paul S Fichtinger 1, Frances J Fogerty 2, Ksenija Bernau 1, Sameer K Mathur 1, Deane F Mosher 2 3, Nathan Sandbo 1, Nizar N Jarjour 1 Abstract Background: The presence of eosinophils in the airway is associated with asthma severity and risk of exacerbations. Cell-free eosinophil granules are found in tissues …

Eosinophil cytolysis on Immunoglobulin G is associated with microtubule formation and suppression of rho-associated protein kinase signalling 더 보기 »

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