Discovery of a novel small molecule as CD47/SIRPα and PD-1/PD-L1 dual inhibitor for cancer immunotherapy
anti-human CD3 (OKT3); anti-human CD28 (CD28.2) ; BioGems ; Cell Commun Signal. 2024 Mar 11;22(1):173. doi: 10.1186/s12964-024-01555-4. Shengzhe Jin # 1, Hongfei Wang # 2, Yang Li # 1, Jingwen Yang 1, Beibei Li 1, Peishang Shi 1, Xiangrui Zhang 1, Xiaowen Zhou 1, Xiuman Zhou 3, Xiaoshuang Niu 3, Menghan Wu 1, Yahong Wu 1 4, Wenjie Zhai 1 4, Yuanming Qi 1, Yanfeng Gao 5, Wenshan Zhao 6 Affiliations expand Abstract Background: Targeting the tumor microenvironment (TME) has emerged as a promising strategy in cancer treatment, particularly through the utilization of …