Novel method of differentiating human induced pluripotent stem cells to mature cardiomyocytes via Sfrp2.
#BG iMatrix-511; #RL511 Ying-Chang Hsueh 1, Richard E Pratt 1, Victor J Dzau 2, Conrad P Hodgkinson 3 Affiliations expand Free PMC article Abstract Current methods to generate cardiomyocytes from induced pluripotent stem cells (iPSc) utilize broad-spectrum pharmacological inhibitors. These methods give rise to cardiomyocytes which are typically immature. Since we have recently demonstrated that cardiomyogenesis in vitro and in vivo requires Sfrp2, …