CLN-617 retains IL-2 and IL-12 in injected tumors to drive robust and systemic immune-mediated antitumor activity

# 10X RBC Lysis Buffer ;  # 64010-00 ;  Cancer Immunol Res. 2024 Jun 6. doi: 10.1158/2326-6066.CIR-23-0636. Online ahead of print. Naveen K Mehta 1, Kavya Rakhra 1, Kristan A Meetze 1, Bochong Li 1, Noor Momin 2, Jason Yh Chang 1, K Dane Wittrup 3, Patrick A Baeuerle 4, Jennifer S Michaelson 1 Affiliations expand Abstract Despite clinical evidence of antitumor activity, the development of cytokine therapies has been hampered by a …

CLN-617 retains IL-2 and IL-12 in injected tumors to drive robust and systemic immune-mediated antitumor activity 더 보기 »

Tobacco-induced hyperglycemia promotes lung cancer progression via cancer cell-macrophage interaction through paracrine IGF2/IR/NPM1-driven PD-L1 expression

# 10X RBC Lysis Buffer ;  # 64010-00 ;  Nat Commun. 2024 Jun 8;15(1):4909. doi: 10.1038/s41467-024-49199-9. Hyun-Ji Jang # 1, Hye-Young Min # 1 2, Yun Pyo Kang 3, Hye-Jin Boo 1 4, Jisung Kim 1, Jee Hwan Ahn 1 5, Seung Ho Oh 3, Jin Hwa Jung 6, Choon-Sik Park 7, Jong-Sook Park 7, Seog-Young Kim 6 8, Ho-Young Lee 9 10 11 Affiliations expand Abstract Tobacco smoking (TS) is implicated in lung cancer (LC) progression through the development of metabolic syndrome. However, direct evidence linking …

Tobacco-induced hyperglycemia promotes lung cancer progression via cancer cell-macrophage interaction through paracrine IGF2/IR/NPM1-driven PD-L1 expression 더 보기 »

Hyperactivation of β-catenin signal in hepatocellular carcinoma recruits myeloid-derived suppressor cells through PF4-CXCR3 axis

# 10X RBC Lysis Buffer ;  # 64010-00 ;  Cancer Lett. 2024 Apr 1:586:216690. doi: 10.1016/j.canlet.2024.216690. Epub 2024 Feb 1. Kaiting Wang 1, Jianmin Wu 2, Zhao Yang 3, Bo Zheng 4, Siyun Shen 4, Rui-Ru Wang 5, Yani Zhang 2, Hong-Yang Wang 6, Lei Chen 7, Xinyao Qiu 8 Affiliations expand Free article Abstract The high mutation rate of CTNNB1 (37 %) and Wnt-β-catenin signal-associated genes (54 %) has been notified in hepatocellular carcinoma …

Hyperactivation of β-catenin signal in hepatocellular carcinoma recruits myeloid-derived suppressor cells through PF4-CXCR3 axis 더 보기 »

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