2’3’-cGAMP
2’3′-cGAMP는 STING(stimulator of IFN genes)에 결합하여 내인성 2차 전달자 역할을 하여 선천성 면역 체계를 활성화합니다. 이것은 cytosolic DNA 자극 시 ATP와 GTP로부터 cyclic GMP-AMP synthase (cGAS)에 의해 생성됩니다.
Additional Information
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Applications:
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FA
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Synonyms:
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cGAMP, cyclic GMP-AMP, cyclic guanosine monophosphate-adenosine monophosphate, Cyclic guanosine monophosphate-adenosine monophosphate
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Formulation:
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Crystalline solid
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Chemical Name:
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2′-O,5′-O-((adenosine-3′-O,5′-O-diyl)bisphosphinico)guanosine
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Molecular Formula:
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C20H24N10O13P2 |
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Molecular Weight:
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674.4
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CAS Number
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1441190-66-4
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Li, X. D., Wu, J., Gao, D., Wang, H., Sun, L., & Chen, Z. J. (2013). Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science, 341(6152), 1390-1394. Kranzusch, P. J., Wilson, S. C., Lee, A. S., Berger, J. M., Doudna, J. A., & Vance, R. E. (2015). Ancient origin of cGAS-STING reveals mechanism of universal 2′, 3′ cGAMP signaling. Molecular cell, 59(6), 891-903. Gao, D., Wu, J., Wu, Y. T., Du, F., Aroh, C., Yan, N., … & Chen, Z. J. (2013). Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science, 341(6148), 903-906. |
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