Forskolin
Forskolin은 adenylyl cyclase를 활성화시켜 세포내 cyclic AMP(cAMP) 수준을 증가시킵니다. 혈관확장(vasodilator) 및 저혈압 특성이 있으며, 줄기 세포의 신경세포로의 분화를 유도하는 데 사용됩니다. 다른 small molecule과 함께 사용하여 배아의 섬유아세포(embryonic fibroblast)를 유도만능줄기세포(induced pluripotent stem cell)로 화학적 재프로그래밍하는데 사용할 수 있는 것으로 보고되어 있습니다.
- Preparation & Storage
Soluble in organic solvents such as ethanol or DMSO. For 2.5mM, 10 mg is dissolved with 9.74 mL of solvent. - Download TDS
- Mazza T, Roumeliotis TI, Garitta E, Drew D, Rashid ST, Indiveri C, Choudhary JS, Linton KJ, Beis K. Structural basis for the modulation of MRP2 activity by phosphorylation and drugs. Nat Commun. 2024 Mar 4;15(1):1983. doi: 10.1038/s41467-024-46392-8. PMID: 38438394; PMCID: PMC10912322.
- Helena GA, Watanabe T, Kato Y, Shiraki N, Kume S. Activation of cAMP (EPAC2) signaling pathway promotes hepatocyte attachment. Sci Rep. 2023 Jul 31;13(1):12352. doi: 10.1038/s41598-023-39712-3. PMID: 37524826; PMCID: PMC10390557.
- Chung, J., Park, J., Lai, Z.W. et al. The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets. Nat Cell Biol (2023). https://doi.org/10.1038/s41556-023-01178-w.
- Brambilla S, Guiotto M, Torretta E, Armenia I, Moretti M, Gelfi C, Palombella S, di Summa PG. Human platelet lysate stimulates neurotrophic properties of human adipose-derived stem cells better than Schwann cell-like cells. Stem Cell Res Ther. 2023 Jul 21;14(1):179. doi: 10.1186/s13287-023-03407-3. PMID: 37480149; PMCID: PMC10362751. [ BioGems 제품이나 PeproTech 으로 표기 ].
- Overeem AW, Chang YW, Moustakas I, Roelse CM, Hillenius S, Helm TV, Schrier VFV, Gonçalves MAFV, Mei H, Freund C, Chuva de Sousa Lopes SM. Efficient and scalable generation of primordial germ cells in Helena GA, Watanabe T, Kato Y, Shiraki N, Kume S. Activation of cAMP (EPAC2) signaling pathway promotes hepatocyte attachment. Sci Rep. 2023 Jul 31;13(1):12352. doi: 10.1038/s41598-023-39712-3. PMID: 37524826; PMCID: PMC10390557.2D culture using basement membrane extract overlay. Cell Rep Methods. 2023 May 23;3(6):100488. doi: 10.1016/j.crmeth.2023.100488. PMID: 37426764; PMCID: PMC10326346.
- Xie X, Tong X, Li Z, Cheng Q, Wang X, Long Y, Liu F, Wang Y, Wang J, Liu L. Use of mouse primary epidermal organoids for USA300 infection modeling and drug screening. Cell Death Dis. 2023 Jan 11;14(1):15. doi: 10.1038/s41419-022-05525-x. PMID: 36631452; PMCID: PMC9833019.
- Zhou G, Da Won Bae S, Nguyen R, Huo X, Han S, Zhang Z, Hebbard L, Duan W, Eslam M, Liddle C, Yuen L, Lam V, Qiao L, George J. An aptamer-based drug delivery agent (CD133-apt-Dox) selectively and effectively kills liver cancer stem-like cells. Cancer Lett. 2021 Mar 31;501:124-132. doi: 10.1016/j.canlet.2020.12.022. Epub 2020 Dec 19. PMID: 33352247.
- Ze Zhong Wang, Matthew D. Wood, Susan E. Mackinnon, Shelly E. Sakiyama-Elbert, A microfluidic platform to study the effects of GDNF on neuronal axon entrapment, Journal of Neuroscience Methods, 308:183-191, ISSN 0165-0270, https://doi.org/10.1016/j.jneumeth.2018.08.002.
- Chiaradonna F, Pirola Y, Ricciardiello F, Palorini R. Transcriptional profiling of immortalized and K-ras-transformed mouse fibroblasts upon PKA stimulation by forskolin in low glucose availability. Genom Data. 2016 Jul 7;9:100-4. doi: 10.1016/j.gdata.2016.07.004. PMID: 27486565; PMCID: PMC4957573.
ADDITIONAL INFORMATION
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Applications:
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FA
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Synonyms:
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Coleonol, colforsin, NKH-477, NSC 375489
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Formulation:
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Crystalline solid
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Chemical Name:
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[(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate
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Molecular Formula:
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C22H34O7 |
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Molecular Weight:
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410.5
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CAS Number
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66575-29-9
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Seamon, K. B., & Daly, J. W. (1980). Forskolin: a unique diterpene activator of cyclic AMP-generating systems. Journal of cyclic nucleotide research, 7(4), 201-224. Laurenza, A., Sutkowski, E. M., & Seamon, K. B. (1989). Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?.Trends in Pharmacological Sciences, 10(11), 442-447. Shamblott, M. J., Axelman, J., Wang, S., Bugg, E. M., Littlefield, J. W., Donovan, P. J., … & Gearhart, J. D. (1998). Derivation of pluripotent stem cells from cultured human primordial germ cells. Proceedings of the National Academy of Sciences, 95(23), 13726-13731. |
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