SB 203580
SB 203580은 p38-specific inhibitor로써 heat shock protein 27 및 MAP kinase-activated protein kinase 2 (MAPKAPK2)의 다운스트림 활성화를 저해합니다. cytokine으로 활성화된 임파구에 대하여 항증식 활성을 나타내며, 심근세포 분화를 촉진시키는데도 사용되는 것으로 보고되었습니다.
- Preparation & Storage
Soluble in organic solvents such as ethanol and DMSO. DMSO up to 20 mg/mL ( 52.9886 mM ). - Download TDS
제품 인용 최신 논문
ADDITIONAL INFORMATION
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Applications:
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FA
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Synonyms:
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SB203580, RWJ 64809, CHEMBL10, CTK8E9223
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Formulation:
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Crystalline solid
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Chemical Name:
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4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
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Molecular Formula:
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C21H16FN3OS |
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Molecular Weight:
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377.4
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CAS Number
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152121-47-6
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Lali, F. V., Hunt, A. E., Turner, S. J., & Foxwell, B. M. (2000). The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase. Journal of Biological Chemistry, 275(10), 7395-7402. Barancik, M., Htun, P., Strohm, C., Kilian, S., & Schaper, W. (2000). Inhibition of the cardiac p38-MAPK pathway by SB203580 delays ischemic cell death.Journal of cardiovascular pharmacology, 35(3), 474-483. Martin, J. L., Avkiran, M., Quinlan, R. A., Cohen, P., & Marber, M. S. (2001). Antiischemic Effects of SB203580 Are Mediated Through the Inhibition of p38α Mitogen-Activated Protein Kinase Evidence From Ectopic Expression of an Inhibition-Resistant Kinase. Circulation research, 89(9), 750-752. |
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