Wnt-C59
Wnt-C59는 매우 강력한 Porcupine (PORCN) inhibitor로써, Wnt-3a의 팔미토일화(palmitoylation), 분비 및 활성화를 방해합니다 (IC50=74pM). Wnt-C59는 Wnt 활성 암세포주의 세포 증식을 억제하는 것으로 보고되었습니다. CHIR 99021과 함께 Wnt-C59는 인간 유도 만능줄기세포(iPSC)로부터 심근세포 분화를 유도하는 데 사용됩니다.
- Preparation & Storage
Soluble in organic solvents such as DMF and DMSO. DMSO up to 20mg/ml. ( 52.7079 mM ). - Download TDS
[제품 인용 최신 논문]
- Karbassi E, Padgett R, Bertero A, Reinecke H, Klaiman JM, Yang X, Hauschka SD, Murry CE. Targeted CRISPR activation is functional in engineered human pluripotent stem cells but undergoes silencing after differentiation into cardiomyocytes and endothelium. Cell Mol Life Sci. 2024 Feb 19;81(1):95. doi: 10.1007/s00018-023-05101-2. PMID: 38372898; PMCID: PMC10876724.
- Liang F, Wang B, Geng J, You G, Fa J, Zhang M, Sun H, Chen H, Fu Q, Zhang X, Zhang Z. SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients. Elife. 2021 Jun 8;10:e67481. doi: 10.7554/eLife.67481. PMID: 34099102; PMCID: PMC8186900.
ADDITIONAL INFORMATION
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Applications:
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FA
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Synonyms:
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WNTC59
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Formulation:
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Crystalline solid
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Chemical Name:
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2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide
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Molecular Formula:
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C25H21N3O |
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Molecular Weight:
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379.5
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CAS Number
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1243243-89-1
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Cheng, Y., Phoon, Y. P., Jin, X., Chong, S. Y. S., Ip, J. C. Y., Wong, B. W. Y., & Lung, M. L. (2015). Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment. Oncotarget, 6(16), 14428. Proffitt, K. D., Madan, B., Ke, Z., Pendharkar, V., Ding, L., Lee, M. A., … & Virshup, D. M. (2013). Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer research, 73(2), 502-507. Kadari, A., Mekala, S., Wagner, N., Malan, D., Köth, J., Doll, K., … & Sasse, P. (2015). Robust generation of cardiomyocytes from human iPS cells requires precise modulation of BMP and WNT signaling. Stem Cell Reviews and Reports, 11(4), 560-569. |
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