IWP-2
IWP-2 는 Wnt 신호전달경로를 억제하며, 이는 Wnt 단백질을 팔미토일화하는 Porcupine O-acyltransferase를 불활성함으로써 이루어 집니다. IWP-2는 배아줄기세포의 자가재생을 억제하며, 인간줄기세포의 심근세포로의 분화를 촉진하는 것으로 보고되었습니다.
- Preparation & Storage
Soluble in organic solvents such as ethanol or DMSO. DMSO up to 5mM. ( 2.33 mg /mL ). - Download TDS
[제품 인용 최신 논문]
- Kim MS, Ra EA, Kweon SH, Seo BA, Ko HS, Oh Y, Lee G. Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation. Cell Stem Cell. 2023 Jul 6;30(7):973-986.e11. doi: 10.1016/j.stem.2023.05.015. Epub 2023 Jun 19. PMID: 37339636.
- Turner DGP, De Lange WJ, Zhu Y, Coe CL, Simcox J, Ge Y, Kamp TJ, Ralphe JC, Glukhov AV. Neutral sphingomyelinase regulates mechanotransduction in human engineered cardiac tissues and mouse hearts. J Physiol. 2023 Oct 27. doi: 10.1113/JP284807. Epub ahead of print. PMID: 37889115.
- Lee Y, Kang JS, Ham OJ, Son MY, Lee MO. Gut metabolite trimethylamine N-oxide induces aging-associated phenotype of midbrain organoids for the induced pluripotent stem cell-based modeling of late-onset disease. Front Aging Neurosci. 2022 Aug 16;14:925227. doi: 10.3389/fnagi.2022.925227. PMID: 36051303; PMCID: PMC9426463.
- Fiorenzano A, Sozzi E, Birtele M, Kajtez J, Giacomoni J, Nilsson F, Bruzelius A, Sharma Y, Zhang Y, Mattsson B, Emnéus J, Ottosson DR, Storm P, Parmar M. Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids. Nat Commun. 2021 Dec 15;12(1):7302. doi: 10.1038/s41467-021-27464-5. PMID: 34911939; PMCID: PMC8674361.
ADDITIONAL INFORMATION
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Applications:
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FA
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Synonyms:
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CHEMBL1257064, F0579-0037
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Formulation:
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Crystalline solid
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Chemical Name:
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N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide
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Molecular Formula:
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C22H18N4O2S3 |
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Molecular Weight:
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466.6
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CAS Number
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686770-61-6
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Purity:
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≥95%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Chen, B., Dodge, M. E., Tang, W., Lu, J., Ma, Z., Fan, C. W., … & Lum, L. (2009). Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature chemical biology, 5(2), 100-107. Loh, Y. N., Hedditch, E. L., Baker, L. A., Jary, E., Ward, R. L., & Ford, C. E. (2013). The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer. BMC cancer, 13(1), 174. Mo, M. L., Li, M. R., Chen, Z., Liu, X. W., Sheng, Q., & Zhou, H. M. (2013). Inhibition of the Wnt palmitoyltransferase porcupine suppresses cell growth and downregulates the Wnt/β-catenin pathway in gastric cancer. Oncology letters,5(5), 1719-1723. |
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