SB 431542
SB 431542는 TGF-beta type I receptor activin receptor-like kinase (ALK) receptors, ALK5, ALK4 및 ALK7의 선택적 억제제이며, BMP type I receptors ALK2, ALK3 및 ALK6에는 작용하지 않습니다. Smad 신호전달을 차단하여 세포 재생을 억제하며, 줄기세포 분화를 촉진하는 것으로 알려져 있습니다.
- Preparation & Storage
Soluble in organic solvents such as ethanol and DMSO. DMSO up to 50 mM ( 19.2195 mg/mL ).
- Download TDS
[ 최신 제품 인용 논문 ]
- Knorr DY, Rodriguez Polo I, Pies HS, Schwedhelm-Domeyer N, Pauls S, Behr R, Heinrich R. The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor. Front Mol Neurosci. 2023 Apr 6;16:1154509. doi: 10.3389/fnmol.2023.1154509. PMID: 37168680; PMCID: PMC10165946.
- Haim-Abadi G, Golan-Lev T, Koren A, Benvenisty N. Generation, genomic characterization, and differentiation of triploid human embryonic stem cells. Stem Cell Reports. 2023 May 9;18(5):1049-1060. doi: 10.1016/j.stemcr.2023.04.001. Epub 2023 Apr 27. PMID: 37116485; PMCID: PMC10202691.
- Tsaytler P, Liu J, Blaess G, Schifferl D, Veenvliet JV, Wittler L, Timmermann B, Herrmann BG, Koch F. BMP4 triggers regulatory circuits specifying the cardiac mesoderm lineage. Development. 2023 May 15;150(10):dev201450. doi: 10.1242/dev.201450. Epub 2023 May 22. PMID: 37082965; PMCID: PMC10233716.
- Welby E, Ebert AD. Diminished motor neuron activity driven by abnormal astrocytic EAAT1 glutamate transporter activity in spinal muscular atrophy is not fully restored after lentiviral SMN delivery. Glia. 2023 May;71(5):1311-1332. doi: 10.1002/glia.24340. Epub 2023 Jan 18. PMID: 36655314.
- Knorr DY, Rodriguez Polo I, Pies HS, Schwedhelm-Domeyer N, Pauls S, Behr R, Heinrich R. The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor. Front Mol Neurosci. 2023 Apr 6;16:1154509. doi: 10.3389/fnmol.2023.1154509. PMID: 37168680; PMCID: PMC10165946. [ BioGems 제품이나 PeproTech 으로 표기 ].
- Skylar-Scott MA, Huang JY, Lu A, Ng AHM, Duenki T, Liu S, Nam LL, Damaraju S, Church GM, Lewis JA. Orthogonally induced differentiation of stem cells for the programmatic patterning of vascularized organoids and bioprinted tissues. Nat Biomed Eng. 2022 Apr;6(4):449-462. doi: 10.1038/s41551-022-00856-8. Epub 2022 Mar 24. PMID: 35332307; PMCID: PMC9506705.
- Ho DLL, Lee S, Du J, Weiss JD, Tam T, Sinha S, Klinger D, Devine S, Hamfeldt A, Leng HT, Herrmann JE, He M, Fradkin LG, Tan TK, Standish D, Tomasello P, Traul D, Dianat N, Ladi R, Vicard Q, Katikireddy K, Skylar-Scott MA. Large-Scale Production of Wholly Cellular Bioinks via the Optimization of Human Induced Pluripotent Stem Cell Aggregate Culture in Automated Bioreactors. Adv Healthc Mater. 2022 Dec;11(24):e2201138. doi: 10.1002/adhm.202201138. Epub 2022 Nov 22. PMID: 36314397; PMCID: PMC10234214.
- Mishra S, Knupp A, Szabo MP, Williams CA, Kinoshita C, Hailey DW, Wang Y, Andersen OM, Young JE. The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons. Cell Mol Life Sci. 2022 Feb 28;79(3):162. doi: 10.1007/s00018-022-04182-9. PMID: 35226190; PMCID: PMC8885486.
- Welby E, Ebert AD. Diminished motor neuron activity driven by abnormal astrocytic EAAT1 glutamate transporter activity in spinal muscular atrophy is not fully restored after lentiviral SMN delivery. Glia. 2023 May;71(5):1311-1332. doi: 10.1002/glia.24340. Epub 2023 Jan 18. PMID: 36655314.Scholz S, Lewis K, Saulich F, Endres M, Boehmerle W, Huehnchen P. Induced pluripotent stem cell-derived brain organoids as potential human model system for chemotherapy induced CNS toxicity. Front Mol Biosci. 2022 Sep 15;9:1006497. doi: 10.3389/fmolb.2022.1006497. PMID: 36188215; PMCID: PMC9520921.
- Scholz S, Lewis K, Saulich F, Endres M, Boehmerle W, Huehnchen P. Induced pluripotent stem cell-derived brain organoids as potential human model system for chemotherapy induced CNS toxicity. Front Mol Biosci. 2022 Sep 15;9:1006497. doi: 10.3389/fmolb.2022.1006497. PMID: 36188215; PMCID: PMC9520921.
- Sears KE, Gullapalli K, Trivedi D, Mihas A, Bukys MA, Jensen J. Controlling neural territory patterning from pluripotency using a systems developmental biology approach. iScience. 2022 Mar 21;25(4):104133. doi: 10.1016/j.isci.2022.104133. PMID: 35434550; PMCID: PMC9010746.
- Deanna Necula, Frances S. Cho, Andrea He, Jeanne T. Paz, Secondary thalamic neuroinflammation after focal cortical stroke and traumatic injury mirrors corticothalamic functional connectivity, Journal of Comparative Neurology, 10.1002/cne.25259, (2021).
Catalog Number : 3014193
ADDITIONAL INFORMATION
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Applications:
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FA
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Synonyms:
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SB-431542, CHEMBL440084, 3tzm, GTPL8216, FHYUGAJXYORMHI-UHFFFAOYSA-N
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Formulation:
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Crystalline solid
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Chemical Name:
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4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
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Molecular Formula:
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C22H16N4O3 |
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Molecular Weight:
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384.4
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CAS Number
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301836-41-9
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Inman, G. J., Nicolás, F. J., Callahan, J. F., Harling, J. D., Gaster, L. M., Reith, A. D., … & Hill, C. S. (2002). SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Molecular pharmacology, 62(1), 65-74. Laping, N. J., Grygielko, E., Mathur, A., Butter, S., Bomberger, J., Tweed, C., … & Olson, B. A. (2002). Inhibition of transforming growth factor (TGF)-β1–induced extracellular matrix with a novel inhibitor of the TGF-β type I receptor kinase activity: SB-431542. Molecular pharmacology, 62(1), 58-64. Halder, S. K., Beauchamp, R. D., & Datta, P. K. (2005). A specific inhibitor of TGF-β receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia, 7(5), 509-521. |
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