Gastrin I
Gastrin 은 펩타이드 호르몬으로, 위산 분비의 주요 생리학적 조절제이면서, 위점막(gastric musocal)의 성장 촉진제입니다. Gastrin은 cholecystokinin B receptors (CCKBR)에 결합하여 세포내 칼슘이온(Ca2+)의 증가, inositol phosphate 생성 및 protein kinase C의 활성화를 촉진합니다. 또한 Gastrin은 위상피세포(gastric epithelial cell) 증식 및 성숙에 관여하며, 위장 organoids 연구에 활용됩니다.
[제품인용 최신논문]
- Ruta V, Naro C, Pieraccioli M, Leccese A, Archibugi L, Cesari E, Panzeri V, Allgöwer C, Arcidiacono PG, Falconi M, Carbone C, Tortora G, Borrelli F, Attili F, Spada C, Quero G, Alfieri S, Doglioni C, Kleger A, Capurso G, Sette C. An alternative splicing signature defines the basal-like phenotype and predicts worse clinical outcome in pancreatic cancer. Cell Rep Med. 2024 Feb 20;5(2):101411. doi: 10.1016/j.xcrm.2024.101411. Epub 2024 Feb 6. PMID: 38325381; PMCID: PMC10897606.
- Yang Z, Zou S, Zhang Y, Zhang J, Zhang P, Xiao L, Xie Y, Meng M, Feng J, Kang L, Lee MH, Fang L. ACTL6A protects gastric cancer cells against ferroptosis through induction of glutathione synthesis. Nat Commun. 2023 Jul 13;14(1):4193. doi: 10.1038/s41467-023-39901-8. PMID: 37443154; PMCID: PMC10345109.
- Wei W, Qin B, Wen W, Zhang B, Luo H, Wang Y, Xu H, Xie X, Liu S, Jiang X, Wang M, Tang Q, Zhang J, Yang R, Fan Z, Lyu H, Lin J, Li K, Lee MH. FBXW7β loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth. Signal Transduct Target Ther. 2023 May 19;8(1):187. doi: 10.1038/s41392-023-01405-8. PMID: 37202390; PMCID: PMC10195794.
- Xu H, Luo H, Zhang J, Li K, Lee MH. Therapeutic potential of Clostridium butyricum anticancer effects in colorectal cancer. Gut Microbes. 2023 Jan-Dec;15(1):2186114. doi: 10.1080/19490976.2023.2186114. PMID: 36941257; PMCID: PMC10038047.
- Zhou G, Da Won Bae S, Nguyen R, Huo X, Han S, Zhang Z, Hebbard L, Duan W, Eslam M, Liddle C, Yuen L, Lam V, Qiao L, George J. An aptamer-based drug delivery agent (CD133-apt-Dox) selectively and effectively kills liver cancer stem-like cells. Cancer Lett. 2021 Mar 31;501:124-132. doi: 10.1016/j.canlet.2020.12.022. Epub 2020 Dec 19. PMID: 33352247.
ADDITIONAL INFORMATION
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Applications:
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FA
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Synonyms:
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GAS, GAST
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Formulation:
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Crystalline solid
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Chemical Name:
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H-Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2
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Molecular Formula:
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C97H124N20O31S |
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Molecular Weight:
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2098.2
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CAS Number
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10047-33-3
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Purity:
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≥95%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Noble, F., Wank, S. A., Crawley, J. N., Bradwejn, J., Seroogy, K. B., Hamon, M., & Roques, B. P. (1999). International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacological Reviews, 51(4), 745-781. Lee, Y., Urbanska, A. M., Hayakawa, Y., Wang, H., Au, A. S., Luna, A. M., … & Friedman, R. A. (2017). Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett’s-like esophagus. Oncotarget, 8(1), 203. Fatehullah, A., Tan, S. H., & Barker, N. (2016). Organoids as an in vitro model of human development and disease. Nature cell biology, 18(3), 246. |
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