SB 202190
SB 202190은 ATP 포켓에 결합하는 선택적이고 강력한 p38 MAP kinase inhibitor입니다. ERK 및 JNK와 같은 다른 MAP kinase 에 대한 억제 특성은 거의 없어 무시할 수 있습니다. SB 202190은 인간 배아줄기세포로부터 심근세포 분화를 유도하고 신경줄기세포의 자가재생을 증가시키는 데 사용되는 것으로 보고되고 있습니다.
- Preparation & Storage
Soluble in organic solvents such as ethanol or DMSO. DMSO up to 45mM. ( 14.9108 mg/mL ).
- Download TDS
[제품 인용 최신 논문]
- Hany D, Zoetemelk M, Bhattacharya K, Nowak-Sliwinska P, Picard D. Network-informed discovery of multidrug combinations for ERα+/HER2-/PI3Kα-mutant breast cancer. Cell Mol Life Sci. 2023 Mar 3;80(3):80. doi: 10.1007/s00018-023-04730-x. PMID: 36869202; PMCID: PMC10032341. [ BioGems 제품이지만 PeproTech 으로 표기 ].
- Gomez-Martinez I, Bliton RJ, Breau KA, Czerwinski MJ, Williamson IA, Wen J, Rawls JF, Magness ST. A Planar Culture Model of Human Absorptive Enterocytes Reveals Metformin Increases Fatty Acid Oxidation and Export. Cell Mol Gastroenterol Hepatol. 2022;14(2):409-434. doi: 10.1016/j.jcmgh.2022.04.009. Epub 2022 Apr 28. PMID: 35489715; PMCID: PMC9305019. [ BioGems 제품이나 PeproTech 으로 표기 ].
- [IF 39.4] Lo YH, Kolahi KS, Du Y, Chang CY, Krokhotin A, Nair A, Sobba WD, Karlsson K, Jones SJ, Longacre TA, Mah AT, Tercan B, Sockell A, Xu H, Seoane JA, Chen J, Shmulevich I, Weissman JS, Curtis C, Califano A, Fu H, Crabtree GR, Kuo CJ. A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation. Cancer Discov. 2021 Jun;11(6):1562-1581. doi: 10.1158/2159-8290.CD-20-1109. Epub 2021 Jan 15. PMID: 33451982; PMCID: PMC8346515.
- Hoareau L, Engelsen AST, Aanerud M, Ramnefjell MP, Salminen PR, Gärtner F, Halvorsen T, Raeder H, Bentsen MHL. Induction of alveolar and bronchiolar phenotypes in human lung organoids. Physiol Rep. 2021 Jun;9(11):e14857. doi: 10.14814/phy2.14857. PMID: 34110705; PMCID: PMC8191394.
- Trapecar M, Wogram E, Svoboda D, Communal C, Omer A, Lungjangwa T, Sphabmixay P, Velazquez J, Schneider K, Wright CW, Mildrum S, Hendricks A, Levine S, Muffat J, Lee MJ, Lauffenburger DA, Trumper D, Jaenisch R, Griffith LG. Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases. Sci Adv. 2021 Jan 29;7(5):eabd1707. doi: 10.1126/sciadv.abd1707. PMID: 33514545; PMCID: PMC7846169. [ BioGems 제품이나 PeproTech 으로 표기 ].
- Zhang J, Huang YJ, Yoon JY, Kemmitt J, Wright C, Schneider K, Sphabmixay P, Hernandez-Gordillo V, Holcomb SJ, Bhushan B, Rohatgi G, Benton K, Carpenter D, Kester JC, Eng G, Breault DT, Yilmaz O, Taketani M, Voigt CA, Carrier RL, Trumper DL, Griffith LG. Primary human colonic mucosal barrier crosstalk with super oxygen-sensitive Faecalibacterium prausnitzii in continuous culture. Med. 2021 Jan 15;2(1):74-98.e9. doi: 10.1016/j.medj.2020.07.001. Epub 2020 Aug 6. PMID: 33511375; PMCID: PMC7839961.
- Kester JC, Brubaker DK, Velazquez J, Wright C, Lauffenburger DA, Griffith LG. Clostridioides difficile-Associated Antibiotics Alter Human Mucosal Barrier Functions by Microbiome-Independent Mechanisms. Antimicrob Agents Chemother. 2020 Mar 24;64(4):e01404-19. doi: 10.1128/AAC.01404-19. PMID: 31988098; PMCID: PMC7179307. [ BioGems 제품이나 PeproTech 으로 표기 ].
Catalog Number : 1523072
Additional Information
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Applications:
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FA
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Synonyms:
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SB-202190, SB202190, FHPI, 4-[4-(4-Fluorphenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol
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Formulation:
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Crystalline solid
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Chemical Name:
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4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1,3-dihydroimidazol-2-ylidene]cyclohexa-2,5-dien-1-one
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Molecular Formula:
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C20H14FN3O |
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Molecular Weight:
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331.3
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CAS Number
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152121-30-7
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Nemoto, S., Xiang, J., Huang, S., & Lin, A. (1998). Induction of apoptosis by SB202190 through inhibition of p38β mitogen-activated protein kinase. Journal of Biological Chemistry, 273(26), 16415-16420. Manthey, C. L., Wang, S. W., Kinney, S. D., & Yao, Z. (1998). SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNAs in monocytes. Journal of leukocyte biology,64(3), 409-417. Hirosawa, M., Nakahara, M., Otosaka, R., Imoto, A., Okazaki, T., & Takahashi, S. (2009). The p38 pathway inhibitor SB202190 activates MEK/MAPK to stimulate the growth of leukemia cells. Leukemia research,33(5), 693-699. |
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