ALK5 Inhibitor (RepSox)
ALK5 inhibitor는 TGF-beta receptor 신호를 선택적으로 억제하여 세포 재프로그래밍의 효율을 증가시킵니다.
또한 췌장 전구세포의 인슐린 생산 세포로의 분화를 유도하는 것으로 보고되고 있습니다.
또한 췌장 전구세포의 인슐린 생산 세포로의 분화를 유도하는 것으로 보고되고 있습니다.
- Preparation & Storage
Soluble in organic solvents such as ethanol or DMSO. For 10 mM, dilute 10 mg with 3.48 mL of DMSO. -
Catalog Number : 4463325
ADDITIONAL INFORMATION
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Applications:
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FA
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Synonyms:
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RepSox, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine, ALK5 Inhibitor II, E616452
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Formulation:
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Crystalline solid
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Chemical Name:
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2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine
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Molecular Formula:
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C17H13N5 |
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Molecular Weight:
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287.3
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CAS Number
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446859-33-2
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Woltjen, K., & Stanford, W. L. (2009). Inhibition of Tgf-β Signaling Improves Mouse Fibroblast Reprogramming. Cell stem cell, 5(5), 457-458. Larsen, D. M. (2013). Evaluation of the TGF-beta inhibitor RepSox on the expression of pluripotency pathways in murine and bovine cells. UTAH STATE UNIVERSITY. Jajosky, A. N., Coad, J. E., Vos, J. A., Martin, K. H., Senft, J. R., Wenger, S. L., & Gibson, L. F. (2014). RepSox Slows Decay of CD34+ Acute Myeloid Leukemia Cells and Decreases T Cell Immunoglobulin Mucin-3 Expression.Stem cells translational medicine, 3(7), 836. |
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