A 83-01
A 83-01은 강력한 ALK 억제제 입니다 (ALK4 IC50 45nM, ALK5 IC50 12nM, ALK7 IC50 7.5nM). A 83-01은 같은 ALK5 억제제인 SB 431542 보다 더 강력합니다. A 82-01은 TGFb에 의한 상피세포의 중간엽으로의 전환 (epithelial-to-mesenchymal transfition) 및 Smad 신호전달을 저해하는 것으로 보고되었습니다. 그러나 bone morphogenetic protein type I receptors (골형성 단백질 I형 수용체), p38 MAP kinase, 또는 extracellular regulated kinase에는 거의 또는 전혀 영향을 주지 않습니다. 또한 iPSCs의 분화를 억제하고 시험관 내 세포 자가 재생을 유지하는 데 사용됩니다.
- Preparation & Storage
Soluble in organic solvents such as ethanol or DMSO. DMSO up to 14mg/ml. ( 33.2131 mM/mL ). - Download TDS
[제품 인용 최신 논문]
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Catalog Number : 9094360
ADDITIONAL INFORMATION
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Applications:
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FA
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Synonyms:
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A-83-01; A83-01, ALK5 Inhibitor IV, Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor IV, A083
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Formulation:
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Crystalline solid
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Chemical Name:
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3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide
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Molecular Formula:
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C25H19N5S |
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Molecular Weight:
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421.5
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CAS Number
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909910-43-6
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Purity:
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≥95%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Tojo, M., Hamashima, Y., Hanyu, A., Kajimoto, T., Saitoh, M., Miyazono, K., … & Imamura, T. (2005). The ALK‐5 inhibitor A‐83‐01 inhibits Smad signaling and epithelial‐to‐mesenchymal transition by transforming growth factor‐β. Cancer science, 96(11), 791-800. Li, W., Wei, W., Zhu, S., Zhu, J., Shi, Y., Lin, T., … & Ding, S. (2009). Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell stem cell, 4(1), 16-19. Zhu, S., Li, W., Zhou, H., Wei, W., Ambasudhan, R., Lin, T., … & Ding, S. (2010). Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell stem cell, 7(6). |
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