Dibutyryl-cAMP, sodium salt
Dibutyryl-cAMP는 cAMP-dependent protein kinases 및 phosphodiesterase 저해제로써 세포투과되는 활성형의, 내인성 cyclic adenosine monophosphate (cAMP)의 유사체입니다. Dibutyryl-cAMP는 vascullar smooth muscle cell의 세포자멸사를 유도하고, neurite growth를 유도하는 것으로 보고되었습니다.
- Preparation & Storage
Soluble in PBS pH 7.2 up to 6.5mM. ( 3.2 mg/mL )
- Download TDS
[제품 인용 최신 논문]
- Szewczyk B, Günther R, Japtok J, Frech MJ, Naumann M, Lee HO, Hermann A. FUS ALS neurons activate major stress pathways and reduce translation as an early protective mechanism against neurodegeneration. Cell Rep. 2023 Jan 24;42(2):112025. PMID: 36696267.
- Glaß H, Jonitz-Heincke A, Petters J, Lukas J, Bader R, Hermann A. Corrosion Products from Metallic Implants Induce ROS and Cell Death in Human Motoneurons In Vitro. J Funct Biomater. 2023 Jul 25;14(8):392. doi: 10.3390/jfb14080392. PMID: 37623637; PMCID: PMC10455184.
- Lee Y, Kang JS, Ham OJ, Son MY, Lee MO. Gut metabolite trimethylamine N-oxide induces aging-associated phenotype of midbrain organoids for the induced pluripotent stem cell-based modeling of late-onset disease. Front Aging Neurosci. 2022 Aug 16;14:925227. doi: 10.3389/fnagi.2022.925227. PMID: 36051303; PMCID: PMC9426463.
- Leclercq A, Ranefall P, Sjunnesson YCB, Hallberg I. Occurrence of late-apoptotic symptoms in porcine preimplantation embryos upon exposure of oocytes to perfluoroalkyl substances (PFASs) under in vitro meiotic maturation. PLoS One. 2022 Dec 28;17(12):e0279551. doi: 10.1371/journal.pone.0279551. PMID: 36576940; PMCID: PMC9797085.
- Valatkaitė E, Baušytė R, Vitkevičienė A, Ramašauskaitė D, Navakauskienė R. Decidualization Potency and Epigenetic Changes in Human Endometrial Origin Stem Cells During Propagation. Front Cell Dev Biol. 2021 Nov 19;9:765265. doi: 10.3389/fcell.2021.765265. PMID: 34869358; PMCID: PMC8640123.
Catalog Number : 1698950
ADDITIONAL INFORMATION
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Applications:
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FA
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Synonyms:
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Bucladesine sodium salt, Actosin, MLS001148197
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Formulation:
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Crystalline solid
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Chemical Name:
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sodium;[(4aR,6R,7R,7aR)-6-[6-(butanoylamino)purin-9-yl]-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl] butanoate
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Molecular Formula:
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C18H23N5O8P Na |
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Molecular Weight:
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491.4
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CAS Number
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16980-89-5
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Purity:
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≥95%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Kahn, A. M., Dolson, G. M., Hise, M. K., Bennett, S. C., & Weinman, E. J. (1985). Parathyroid hormone and dibutyryl cAMP inhibit Na+/H+ exchange in renal brush border vesicles. American Journal of Physiology-Renal Physiology, 248(2), F212-F218. Leonard, J. L. (1988). Dibutyryl cAMP induction of type II 5′ deiodinase activity in rat brain astrocytes in culture. Biochemical and biophysical research communications, 151(3), 1164-1172. Rundfeldt, C., Steckel, H., Sörensen, T., & Wlaz, P. (2012). The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation. Archives of dermatological research, 304(4), 313-317. |
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