Prostaglandin E2
Prostaglandin E2는 생물학적으로 활성도가 가장 높은 prostaglandin 으로, 거의 모든 세포 유형에 일정 수준으로 존재합니다. EP1, EP2, EP3 및 EP4 수용체에 결합하여 평활근(smooth muscle) 이완, 염증, 생식, 수면 주기 조절, 위점막(gastric mucosal)의 무결성 등 에 관여합니다.
- Preparation & Storage
Soluble in ethanol and DMSO. 10mg in 2.84 mL DMSO or ethanol is 10mM. - Download TDS
[ 최신 제품 인용 논문 ]
- Shen Z, Luo W, Tan B, Nie K, Deng M, Wu S, Xiao M, Wu X, Meng X, Tong T, Zhang C, Ma K, Liao Y, Xu J, Wang X. Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn’s disease. EBioMedicine. 2022 Nov;85:104285. doi: 10.1016/j.ebiom.2022.104285. Epub 2022 Sep 28. PMID: 36182776; PMCID: PMC9526137.
- Lim JY, Lee JE, Kim HK, Park YJ, Jeon JH, Park SA, Lee N, Lee IH, Kim DH, Yang SH, Yoo J, Kim SW. Human Palatine Tonsils Are Linked to Alzheimer’s Disease through Function of Reservoir of Amyloid Beta Protein Associated with Bacterial Infection. Cells. 2022 Jul 24;11(15):2285. doi: 10.3390/cells11152285. PMID: 35892582; PMCID: PMC9330135.
- Gomez-Martinez I, Bliton RJ, Breau KA, Czerwinski MJ, Williamson IA, Wen J, Rawls JF, Magness ST. A Planar Culture Model of Human Absorptive Enterocytes Reveals Metformin Increases Fatty Acid Oxidation and Export. Cell Mol Gastroenterol Hepatol. 2022;14(2):409-434. doi: 10.1016/j.jcmgh.2022.04.009. Epub 2022 Apr 28. PMID: 35489715; PMCID: PMC9305019. [ BioGems 제품이나 PeproTech 으로 표기 ]
- Kim HK, Kim H, Lee MK, Choi WH, Jang Y, Shin JS, Park JY, Bae DH, Hyun SI, Kim KH, Han HW, Lim B, Choi G, Kim M, Chang Lim Y, Yoo J. Generation of human tonsil epithelial organoids as an ex vivo model for SARS-CoV-2 infection. Biomaterials. 2022 Apr;283:121460. doi: 10.1016/j.biomaterials.2022.121460. Epub 2022 Mar 7. PMID: 35286852; PMCID: PMC8901203.
- Urbano, P., Angus, H. C., Gadeock, S., Schultz, M., & Kemp, R. A. (2022). Assessment of source material for human intestinal organoid culture for research and clinical use. BMC research notes, 15(1), 1-8.
- Zhang J, Huang YJ, Yoon JY, Kemmitt J, Wright C, Schneider K, Sphabmixay P, Hernandez-Gordillo V, Holcomb SJ, Bhushan B, Rohatgi G, Benton K, Carpenter D, Kester JC, Eng G, Breault DT, Yilmaz O, Taketani M, Voigt CA, Carrier RL, Trumper DL, Griffith LG. Primary human colonic mucosal barrier crosstalk with super oxygen-sensitive Faecalibacterium prausnitzii in continuous culture. Med. 2021 Jan 15;2(1):74-98.e9. doi: 10.1016/j.medj.2020.07.001. Epub 2020 Aug 6. PMID: 33511375; PMCID: PMC7839961.
ADDITIONAL INFORMATION
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Applications:
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FA
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Synonyms:
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Dinoprostone, PGE2, 13E-dien-1-oic acid
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Formulation:
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Crystalline solid
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Chemical Name:
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(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid
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Molecular Formula:
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C20H32O5 |
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Molecular Weight:
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352.5
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CAS Number
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363-24-6
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at-20°C.
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References:
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Sheng, H., Shao, J., Morrow, J. D., Beauchamp, R. D., & DuBois, R. N. (1998). Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Research, 58(2), 362-366. Betz, M., & Fox, B. S. (1991). Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. The Journal of Immunology, 146(1), 108-113. Kunkel, S. L., Spengler, M., May, M. A., Spengler, R., Larrick, J., & Remick, D. (1988). Prostaglandin E2 regulates macrophage-derived tumor necrosis factor gene expression. Journal of Biological Chemistry, 263(11), 5380-5384. |
상품평
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