Cyclopamine
Cyclopamine는 배아발달의 필수신호전달 경로인 Hedgehog pathway의 스테로이드성 알칼로이드 inhibitor 입니다. Hedgehog 활성을 억제하여, 줄기세포의 내분비세포로의 분화를 유도하거나, 다양한 항암 효과를 유도할 수 있는 것으로 보고되었습니다.
- Preparation & Storage
Soluble in organic solvents such as ethanol. Ethanol up to 24mM ( 9.8789 mg/mL ) - Download TDS
ADDITIONAL INFORMATION
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Applications:
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FA
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Synonyms:
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11-Deoxojervine, MLS006010945, Jervine
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Formulation:
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Crystalline solid
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Chemical Name:
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(3S,3’R,3’aS,6’S,6aS,6bS,7’aR,9R,11aS,11bR)-3′,6′,10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2′-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol
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Molecular Formula:
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C27H41NO2 |
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Molecular Weight:
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411.6
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CAS Number
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4449-51-8
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Taipale, J., Chen, J. K., Cooper, M. K., Wang, B., Mann, R. K., Milenkovic, L., … & Beachy, P. A. (2000). Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature, 406(6799), 1005-1009. Chen, J. K., Taipale, J., Cooper, M. K., & Beachy, P. A. (2002). Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes & development, 16(21), 2743-2748. Bar, E. E., Chaudhry, A., Lin, A., Fan, X., Schreck, K., Matsui, W., … & Eberhart, C. G. (2007). Cyclopamine‐Mediated Hedgehog Pathway Inhibition Depletes Stem‐Like Cancer Cells in Glioblastoma. Stem cells, 25(10), 2524-2533. |
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