Dorsomorphin
Dorsomorphin은 ALK2, ALK3 및 ALK6 수용체를 통한 BMP pathway의 강력하고 선택적인 억제제입니다. 또한 AMP 활성 단백질 키나아제(AMPK)의 선택적이고 가역적인 억제제입니다. Dorsomorphin은 특정 세포 분화를 촉진하고 암세포주의 자가포식(autophagy)을 유도하는 데 유용한 것으로 보고되었습니다.
- Preparation & Storage
Soluble in organic solvents such as DMSO or DMF. Can be dissolved in DMSO up to 3mg/ml ( 7.5096 mM ) with sonication. - Download TDS
[ 최신 제품 인용 논문]
- Knorr DY, Rodriguez Polo I, Pies HS, Schwedhelm-Domeyer N, Pauls S, Behr R, Heinrich R. The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor. Front Mol Neurosci. 2023 Apr 6;16:1154509. doi: 10.3389/fnmol.2023.1154509. PMID: 37168680; PMCID: PMC10165946.
- Chung, J., Park, J., Lai, Z.W. et al. The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets. Nat Cell Biol (2023). https://doi.org/10.1038/s41556-023-01178-w
ADDITIONAL INFORMATION
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Applications:
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FA
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Synonyms:
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Compound C, AMPK Inhibitor, BML-275
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Formulation:
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Crystalline solid
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Chemical Name:
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6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
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Molecular Formula:
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C24H25N5O |
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Molecular Weight:
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399.5
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CAS Number
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866405-64-3
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Paul, B. Y., Hong, C. C., Sachidanandan, C., Babitt, J. L., Deng, D. Y., Hoyng, S. A., … & Peterson, R. T. (2008). Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nature chemical biology, 4(1), 33-41. Hao, J., Daleo, M. A., Murphy, C. K., Yu, P. B., Ho, J. N., Hu, J., … & Hong, C. C. (2008). Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PloS one, 3(8), e2904. Boergermann, J. H., Kopf, J., Yu, P. B., & Knaus, P. (2010). Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. The international journal of biochemistry & cell biology, 42(11), 1802-1807. |
상품평
아직 상품평이 없습니다.