A8301-10mg
A83-01-25mg

A 83-01

카테고리: , , 태그: , , ,

A 83-01

A 83-01은 강력한 ALK 억제제 입니다 (ALK4 IC50 45nM, ALK5 IC50 12nM, ALK7 IC50 7.5nM).

A 83-01은 같은 ALK5 억제제인 SB 431542 보다 더 강력합니다.  A 82-01은 TGFb에 의한 상피세포의 중간엽으로의 전환 (epithelial-to-mesenchymal transfition) 및 Smad 신호전달을 저해하는 것으로 보고되었습니다.

그러나 bone morphogenetic protein type I receptors (골형성 단백질 I형 수용체), p38 MAP kinase, 또는 extracellular regulated kinase에는 거의 또는 전혀 영향을 주지 않습니다. 또한  iPSCs의 분화를 억제하고 시험관 내 세포 자가 재생을 유지하는 데 사용됩니다.

Catalog Number : 9094360
SIZE 가격 (부가세별도) 제품번호
10mg $105.00 9094360-10mg
25mg $240.00 9094360-25mg
  • Preparation & Storage : Soluble in organic solvents such as ethanol or DMSO. DMSO up to 14mg/ml ( 33.2131 mM/mL ).  Product should be kept at -20°C.

  • Download TDS

 

[제품 인용 최신 논문]

  1. Gómez-Álvarez M, Bueno-Fernandez C, Rodríguez-Eguren A, Francés-Herrero E, Agustina-Hernández M, Faus A, Gisbert Roca F, Martínez-Ramos C, Galán A, Pellicer A, Ferrero H, Cervelló I. Hybrid Endometrial-Derived Hydrogels: Human Organoid Culture Models and In Vivo Perspectives. Adv Healthc Mater. 2024 Apr;13(11):e2303838. doi: 10.1002/adhm.202303838. Epub 2023 Nov 27. PMID: 37983675.  [BioGems 제품이나 Peprotech 으로 표기]
  2. Totonji S, Ramos-Triguero A, Willmann D, Sum M, Urban S, Bauer H, Rieder A, Wang S, Greschik H, Metzger E, Schüle R. Lysine Methyltransferase 9 (KMT9) Is an Actionable Target in Muscle-Invasive Bladder Cancer. Cancers (Basel). 2024 Apr 17;16(8):1532. doi: 10.3390/cancers16081532. PMID: 38672614; PMCID: PMC11049522. [BioGems 제품이나 Peprotech 으로 표기]
  3. Stüve P, Nerb B, Harrer S, Wuttke M, Feuerer M, Junger H, Eggenhofer E, Lungu B, Laslau S, Ritter U. Analysis of organoid and immune cell co-cultures by machine learning-empowered image cytometry. Front Med (Lausanne). 2024 Jan 17;10:1274482. doi: 10.3389/fmed.2023.1274482. PMID: 38298516; PMCID: PMC10827864.
  4. Rizo JA, Spencer TE, Kelleher AM. Protocol for the establishment and characterization of an endometrial-derived epithelial organoid and stromal cell co-culture system.  STAR Protoc. 2024 Feb 15;5(1):102894.  PMID: 38363685; PMCID: PMC10879800.
  5. Delacher M, Schmidleithner L, Simon M, Stüve P, Sanderink L, Hotz-Wagenblatt A, Wuttke M, Schambeck K, Ruhland B, Hofmann V, Bittner S, Ritter U, Pant A, Helbich SS, Voss M, Lemmermann NA, Bessiri-Schake L, Bohn T, Eigenberger A, Menevse AN, Gebhard C, Strieder N, Abken H, Rehli M, Huehn J, Beckhove P, Hehlgans T, Junger H, Geissler EK, Prantl L, Werner JM, Schmidl C, Brors B, Imbusch CD, Feuerer M. The effector program of human CD8 T cells supports tissue remodeling. J Exp Med. 2024 Feb 5;221(2):e20230488. doi: 10.1084/jem.20230488. Epub 2024 Jan 16. PMID: 38226976; PMCID: PMC10791561.
  6. Xiong G, Xie N, Nie M, Ling R, Yun B, Xie J, Ren L, Huang Y, Wang W, Yi C, Zhang M, Xu X, Zhang C, Zou B, Zhang L, Liu X, Huang H, Chen D, Cao W, Wang C. Single-cell transcriptomics reveals cell atlas and identifies cycling tumor cells responsible for recurrence in ameloblastoma. Int J Oral Sci. 2024 Feb 29;16(1):21. doi: 10.1038/s41368-024-00281-4. PMID: 38424060; PMCID: PMC10904398.  [BioGems 제품이나 Peprotech 으로 표기]
  7. Liu B, Zhu Y, Yang Z, Yan HHN, Leung SY, Shi J. Deep Learning-Based 3D Single-Cell Imaging Analysis Pipeline Enables Quantification of Cell-Cell Interaction Dynamics in the Tumor Microenvironment. Cancer Res. 2024 Feb 15;84(4):517-526. doi: 10.1158/0008-5472.CAN-23-1100. PMID: 38085180.  [BioGems 제품이나 Peprotech 으로 표기]
  8. Choi SY, Shim J, Gu DE, Kim SY, Kim HJ, Shin DY, Chung MK. Clonal evolution of long-term expanding head and neck cancer organoid: Impact on treatment response for personalized therapeutic screening. Oral Oncol. 2023 Nov;146:106571. doi: 10.1016/j.oraloncology.2023.106571. Epub 2023 Sep 21. PMID: 37741019.
  9. Xu X, Xie J, Ling R, Ouyang S, Xiong G, Lu Y, Yun B, Zhang M, Wang W, Liu X, Chen D, Wang C. Single-cell transcriptomic analysis uncovers the origin and intratumoral heterogeneity of parotid pleomorphic adenoma. Int J Oral Sci. 2023 Sep 7;15(1):38. doi: 10.1038/s41368-023-00243-2. PMID: 37679344; PMCID: PMC10484943.
  10. Karvas RM, Zemke JE, Ali SS, Upton E, Sane E, Fischer LA, Dong C, Park KM, Wang F, Park K, Hao S, Chew B, Meyer B, Zhou C, Dietmann S, Theunissen TW. 3D-cultured blastoids model human embryogenesis from pre-implantation to early gastrulation stages. Cell Stem Cell. 2023 Sep 7;30(9):1148-1165.e7. doi: 10.1016/j.stem.2023.08.005. PMID: 37683602.
  11. Gnecco JS, Brown A, Buttrey K, Ives C, Goods BA, Baugh L, Hernandez-Gordillo V, Loring M, Isaacson KB, Griffith LG. Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk. Med. 2023 Aug 11;4(8):554-579.e9. doi: 10.1016/j.medj.2023.07.004. PMID: 37572651.
  12. Jason A. Rizo, Kimberly M. Davenport, Wipawee Winuthayanon, Thomas E. Spencer, Andrew M. Kelleher, Estrogen receptor alpha regulates uterine epithelial lineage specification and homeostasis, iScience, Volume 26, Issue 9, 2023, 107568. doi.org/10.1016/j.isci.2023.107568.
  13. Yang Z, Zou S, Zhang Y, Zhang J, Zhang P, Xiao L, Xie Y, Meng M, Feng J, Kang L, Lee MH, Fang L. ACTL6A protects gastric cancer cells against ferroptosis through induction of glutathione synthesis. Nat Commun. 2023 Jul 13;14(1):4193. doi: 10.1038/s41467-023-39901-8. PMID: 37443154; PMCID: PMC10345109.
  14. Wei W, Qin B, Wen W, Zhang B, Luo H, Wang Y, Xu H, Xie X, Liu S, Jiang X, Wang M, Tang Q, Zhang J, Yang R, Fan Z, Lyu H, Lin J, Li K, Lee MH. FBXW7β loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth. Signal Transduct Target Ther. 2023 May 19;8(1):187. doi: 10.1038/s41392-023-01405-8. PMID: 37202390; PMCID: PMC10195794.
  15. Ito F, Kato K, Yanatori I, Maeda Y, Murohara T, Toyokuni S. Matrigel-based organoid culture of malignant mesothelioma reproduces cisplatin sensitivity through CTR1. BMC Cancer. 2023 May 31;23(1):487. doi: 10.1186/s12885-023-10966-4. PMID: 37254056; PMCID: PMC10230733.
  16. Xu H, Luo H, Zhang J, Li K, Lee MH. Therapeutic potential of Clostridium butyricum anticancer effects in colorectal cancer. Gut Microbes. 2023 Jan-Dec;15(1):2186114. doi: 10.1080/19490976.2023.2186114. PMID: 36941257; PMCID: PMC10038047.
  17. Zhang B, Liu Q, Wen W, Gao H, Wei W, Tang A, Qin B, Lyu H, Meng X, Li K, Jin H, Yu F, Pan Q, Lin J, Lee MH. The chromatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitochondrial dynamics via EGF and Wnt signaling. Cell Discov. 2022 Dec 6;8(1):130. doi: 10.1038/s41421-022-00478-z. PMID: 36473865; PMCID: PMC9727023.
  18. Sears KE, Gullapalli K, Trivedi D, Mihas A, Bukys MA, Jensen J. Controlling neural territory patterning from pluripotency using a systems developmental biology approach. iScience. 2022 Mar 21;25(4):104133. doi: 10.1016/j.isci.2022.104133. PMID: 35434550; PMCID: PMC9010746.
  19. Hoareau L, Engelsen AST, Aanerud M, Ramnefjell MP, Salminen PR, Gärtner F, Halvorsen T, Raeder H, Bentsen MHL. Induction of alveolar and bronchiolar phenotypes in human lung organoids. Physiol Rep. 2021 Jun;9(11):e14857. doi: 10.14814/phy2.14857. PMID: 34110705; PMCID: PMC8191394.
  20. Zhang J, Huang YJ, Yoon JY, Kemmitt J, Wright C, Schneider K, Sphabmixay P, Hernandez-Gordillo V, Holcomb SJ, Bhushan B, Rohatgi G, Benton K, Carpenter D, Kester JC, Eng G, Breault DT, Yilmaz O, Taketani M, Voigt CA, Carrier RL, Trumper DL, Griffith LG. Primary human colonic mucosal barrier crosstalk with super oxygen-sensitive Faecalibacterium prausnitzii in continuous culture. Med (NY). 2021 Jan 15;2(1):74-98.e9. doi: 10.1016/j.medj.2020.07.001. Epub 2020 Aug 6. PMID: 33511375; PMCID: PMC7839961.
  21. Taketani M, Zhang J, Zhang S, Triassi AJ, Huang YJ, Griffith LG, Voigt CA. Genetic circuit design automation for the gut resident species Bacteroides thetaiotaomicron. Nat Biotechnol. 2020 Aug;38(8):962-969. doi: 10.1038/s41587-020-0468-5. Epub 2020 Mar 30. Erratum in: Nat Biotechnol. 2020 Aug;38(8):1001. PMID: 32231334; PMCID: PMC8922546.

 

Catalog Number : 9094360
product image

ADDITIONAL INFORMATION

Applications:
FA
Synonyms:
A-83-01; A83-01, ALK5 Inhibitor IV, Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor IV, A083
Formulation:
Crystalline solid
Chemical Name:
3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide
Molecular Formula:

C25H19N5S
Molecular Weight:
421.5
CAS Number
909910-43-6
Purity:
≥95%
Storage Conditions:
Product should be kept at -20°C.
References:

Tojo, M., Hamashima, Y., Hanyu, A., Kajimoto, T., Saitoh, M., Miyazono, K., … & Imamura, T. (2005). The ALK‐5 inhibitor A‐83‐01 inhibits Smad signaling and epithelial‐to‐mesenchymal transition by transforming growth factor‐β. Cancer science, 96(11), 791-800.

Li, W., Wei, W., Zhu, S., Zhu, J., Shi, Y., Lin, T., … & Ding, S. (2009). Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell stem cell, 4(1), 16-19.

Zhu, S., Li, W., Zhou, H., Wei, W., Ambasudhan, R., Lin, T., … & Ding, S. (2010). Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell stem cell, 7(6).

상품평

아직 상품평이 없습니다.

“A 83-01”의 첫 상품평을 남겨주세요

연관 상품

Shopping Cart
Scroll to Top