FTY720
FTY720은 sphingosine-1-phosphate receptor 조절제로써, 림프절의 림프구를 격리하여 자가 면역 반응에 대한 림프구의 관여를 억제합니다.
또한 cPLA2 억제제, 세라마이드 합성효소(ceramide synthase) 억제제, 칸나비노이드 수용체 길항제로도 보고되어 있습니다.
FTY720은 곰팡이 대사산물인 myriocin(ISP-1)의 유도체입니다.
ADDITIONAL INFORMATION
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Applications:
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FA
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Synonyms:
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Fingolimod hydrochloride, Fty-720, Fingolimod HCl
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Formulation:
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Crystalline solid
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Chemical Name:
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2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol;hydrochloride
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Molecular Formula:
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C19H33NO2 HCl |
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Molecular Weight:
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343.9
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CAS Number
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162359-56-0
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Brinkmann, V., Davis, M. D., Heise, C. E., Albert, R., Cottens, S., Hof, R., … & Lynch, K. R. (2002). The immune modulator FTY720 targets sphingosine 1-phosphate receptors. Journal of Biological Chemistry, 277(24), 21453-21457. Gräler, M. H., & Goetzl, E. J. (2004). The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. The FASEB journal, 18(3), 551-553. Chiba, K., Yanagawa, Y., Masubuchi, Y., Kataoka, H., Kawaguchi, T., Ohtsuki, M., & Hoshino, Y. (1998). FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. The Journal of Immunology, 160(10), 5037-5044. |
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