StemRegenin 1 (SR1)

StemRegenin 1 (SR1)은 aryl hydrocarbon receptor의 선택적/가역적 길항제로서 CD34+ 세포에서 50% 저해 농도 (IC50)는 127 nM입니다.

CD34의 세포 발현을 유지함으로써 배양 중인 인간 조혈 줄기세포의 자가 재생을 촉진하는 것으로 보고되고 있습니다.

또한 StemRegenin 1 (SR1)은 CD34+ 조혈전구세포의 수지상세포로의 증식 및 분화를 촉진합니다.

**Catalog Number : 1224999**
SIZE	가격 (부가세별도)	제품번호
1mg	$40.00	1224999-1
10mg	$175.00	1224999-10

Catalog Number : 1224999

Applications:	FA
Synonyms:	StemRegenin-1
Formulation:	Crystalline solid
Chemical Name:	4-[2-[[2-(1-benzothiophen-3-yl)-9-propan-2-ylpurin-6-yl]amino]ethyl]phenol
Molecular Formula:	C₂₄H₂₃N₅OS
Molecular Weight:	429.5
CAS Number	1227633-49-9
Purity:	≥98%
Storage Conditions:	Product should be kept at -20°C.
References:	Thordardottir, S., Hangalapura, B. N., Hutten, T., Cossu, M., Spanholtz, J., Schaap, N., … & Dolstra, H. (2013). The aryl hydrocarbon receptor antagonist StemRegenin 1 promotes human plasmacytoid and myeloid dendritic cell development from CD34+ hematopoietic progenitor cells. Stem cells and development, 23(9), 955-967. Boitano, A. E., Wang, J., Romeo, R., Bouchez, L. C., Parker, A. E., Sutton, S. E., … & Schultz, P. G. (2010). Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science,329(5997), 1345-1348. Gori, J. L., Chandrasekaran, D., Kowalski, J. P., Adair, J. E., Beard, B. C., D’Souza, S. L., & Kiem, H. P. (2012). Efficient generation, purification, and expansion of CD34+ hematopoietic progenitor cells from nonhuman primate–induced pluripotent stem cells. Blood, 120(13), e35-e44