Ionomycin Calcium Salt

Ionomycin은 Streptomyces conglobatus에서 발견된 세포 내 칼슘 연구에 사용되는 ionphore 입니다.
또한 IL-2, IL-4 및 perforin의 세포 내 생성을 자극하는 것으로 보고되었습니다. 보관이 용이하도록 칼슘염 형태로 공급됩니다.

SIZE	PRICE(부가세별도)	제품번호
1mg	$35.00	5608212-1mg
10mg	$245.00	5608212-10mg

Preparation & Storage
Soluble in organic solvents such as ethanol or DMSO. DMSO up to 1.5 mg/ml ( 2 mM ).
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[제품 인용 최신 논문]

Zheng SJ, Luo Y, Wang JB, Chen XM, Xu Y, Xiao JH. Regulated intestinal microbiota and gut immunity to ameliorate type 1 diabetes mellitus: A novel mechanism for stem cell-based therapy. Biomed Pharmacother. 2024 Jan;170:116033. doi: 10.1016/j.biopha.2023.116033. Epub 2023 Dec 20. PMID: 38128181.
Niu C, Xu W, Xiong S. Appendectomy Mitigates Coxsackievirus B3-Induced Viral Myocarditis. Viruses. 2023 Sep 22;15(10):1974. doi: 10.3390/v15101974. PMID: 37896753; PMCID: PMC10611117.
Lu L, Zi H, Zhou J, Huang J, Deng Z, Tang Z, Li L, Shi X, Lo PC, Lovell JF, Deng D, Wan C, Jin H. Engineered Microparticles for Treatment of Murine Brain Metastasis by Reprograming Tumor Microenvironment and Inhibiting MAPK Pathway. Adv Sci (Weinh). 2023 Mar;10(8):e2206212. doi: 10.1002/advs.202206212. Epub 2023 Jan 25. PMID: 36698296; PMCID: PMC10015898.
Qin L, Song Y, Zhang F, Wang R, Zhou L, Jin S, Chen C, Li C, Wang M, Jiang B, Sun G, Ma C, Gong Y, Li P. CRL4B complex-mediated H2AK119 monoubiquitination restrains Th1 and Th2 cell differentiation. Cell Death Differ. 2023 Jun;30(6):1488-1502. doi: 10.1038/s41418-023-01155-8. Epub 2023 Apr 6. PMID: 37024604; PMCID: PMC10244459.
Cao W, Sturmlechner I, Zhang H, Jin J, Hu B, Jadhav RR, Fang F, Weyand CM, Goronzy JJ. TRIB2 safeguards naive T cell homeostasis during aging. Cell Rep. 2023 Mar 28;42(3):112195. doi: 10.1016/j.celrep.2023.112195. Epub 2023 Mar 6. PMID: 36884349; PMCID: PMC10118747.
Ma X, Wang Q, Sun C, Agarwal I, Wu H, Chen J, Zhao C, Qi G, Teng Q, Yuan C, Yan S, Peng J, Li R, Song K, Zhang Q, Kong B. Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8⁺ T cell exhaustion via TRIM14-IFN-β axis. Cell Rep. 2023 Aug 29;42(8):112944. doi: 10.1016/j.celrep.2023.112944. Epub 2023 Aug 10. PMID: 37566545.
Tepe ZG, Yazıcı YY, Tank U, Köse LI, Özer M, Aytekin C, Belkaya S. Inherited IRAK-4 Deficiency in Acute Human Herpesvirus-6 Encephalitis. J Clin Immunol. 2023 Jan;43(1):192-205. doi: 10.1007/s10875-022-01369-4. Epub 2022 Oct 7. PMID: 36205835; PMCID: PMC9540208.
Karagiannis F, Peukert K, Surace L, Michla M, Nikolka F, Fox M, Weiss P, Feuerborn C, Maier P, Schulz S, Al B, Seeliger B, Welte T, David S, Grondman I, de Nooijer AH, Pickkers P, Kleiner JL, Berger MM, Brenner T, Putensen C; Bonn COVIMMUNE Consortium; Kato H, Garbi N, Netea MG, Hiller K, Placek K, Bode C, Wilhelm C. Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19. Nature. 2022 Sep;609(7928):801-807. doi: 10.1038/s41586-022-05128-8. Epub 2022 Jul 28. PMID: 35901960; PMCID: PMC9428867.
Zhao X, Zhao R, Nie G. Nanocarriers based on bacterial membrane materials for cancer vaccine delivery. Nat Protoc. 2022 Oct;17(10):2240-2274. doi: 10.1038/s41596-022-00713-7. Epub 2022 Jul 25. PMID: 35879454.
Cardoso A, Martins AC, Maceiras AR, Liu W, Castro I, Castro AG, Bandeira A, Di Santo JP, Cumano A, Li Y, Vieira P, Saraiva M. Interleukin-10 induces interferon-γ-dependent emergency myelopoiesis. Cell Rep. 2021 Oct 26;37(4):109887. doi: 10.1016/j.celrep.2021.109887. PMID: 34706233.
Li W, Chen JY, Sun C, Sparks RP, Pantano L, Rahman RU, Moran SP, Pondick JV, Kirchner R, Wrobel D, Bieler M, Sauer A, Ho Sui SJ, Doerner JF, Rippmann JF, Mullen AC. Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells. Elife. 2022 May 26;11:e74513. doi: 10.7554/eLife.74513. PMID: 35617485; PMCID: PMC9135407.
Tepe ZG, Yazıcı YY, Tank U, Köse LI, Özer M, Aytekin C, Belkaya S. Inherited IRAK-4 Deficiency in Acute Human Herpesvirus-6 Encephalitis. J Clin Immunol. 2023 Jan;43(1):192-205. doi: 10.1007/s10875-022-01369-4. Epub 2022 Oct 7. PMID: 36205835; PMCID: PMC9540208.
Song C, Wang L, Li Q, Liao B, Qiao W, Li Q, Dong N, Li L. Generation of individualized immunocompatible endothelial cells from HLA-I-matched human pluripotent stem cells. Stem Cell Res Ther. 2022 Feb 2;13(1):48. doi: 10.1186/s13287-022-02720-7. Erratum in: Stem Cell Res Ther. 2022 Feb 28;13(1):83. PMID: 35109922; PMCID: PMC8812039.
Liu Q, Xu R, Xu X, Huang Y, Ma Z. Characteristics and significance of T lymphocyte subsets in peripheral blood of osteosarcoma mice. Transl Cancer Res. 2022 Jun;11(6):1503-1509. doi: 10.21037/tcr-22-264. PMID: 35836540; PMCID: PMC9273662.

Catalog Number : 5608212

ADDITIONAL INFORMATION

Applications:	FA
Synonyms:	IONOMYCINCALCIUMSALT
Formulation:	Crystalline solid
Chemical Name:	calcium;(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-19,21-dihydroxy-22-[(2S,5S)-5-[(2R,5S)-5-[(1R)-1-hydroxyethyl]-5-methyloxolan-2-yl]-5-methyloxolan-2-yl]-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxodocosa-10,16-dienoate
Molecular Formula:	C₄₁H₇₀O₉ Ca
Molecular Weight:	747.1
CAS Number	56092-82-1
Purity:	≥98%
Storage Conditions:	Product should be kept at -20°C.
References:	Liu, C. M., & Hermann, T. E. (1978). Characterization of ionomycin as a calcium ionophore. Journal of Biological Chemistry, 253(17), 5892-5894. Morgan, A. J., & Jacob, R. (1994). Ionomycin enhances Ca2+ influx by stimulating store-regulated cation entry and not by a direct action at the plasma membrane. Biochem. J, 300, 665-672. Elzi, D. J., Bjornsen, A. J., MacKenzie, T., Wyman, T. H., & Silliman, C. C. (2001). Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils. American Journal of Physiology-Cell Physiology, 281(1), C350-C360.