LY294002
LY294002는 phosphoinositide 3-kinases (PI3K) 및 BET단백질에 대한 morpholine을 함유한 강력한 가역적 억제제입니다. 배아 세포로부터 인슐린 생산 세포로의 분화를 촉진하고 난소암의 성장을 억제하는 것으로 보고되어 있습니다.
- Preparation & Storage
Soluble in organic solvents such as ethanol or DMSO. DMSO up to 50mM ( 15.367 mg/mL ) - Download TDS
[제품 인용 최신 논문]
- Leyria J, Benrabaa S, Nouzova M, Noriega FG, Tose LV, Fernandez-Lima F, Orchard I, Lange AB. Crosstalk between Nutrition, Insulin, Juvenile Hormone, and Ecdysteroid Signaling in the Classical Insect Model, Rhodnius prolixus. Int J Mol Sci. 2022 Dec 20;24(1):7. doi: 10.3390/ijms24010007. PMID: 36613451; PMCID: PMC9819625.
- Chen, B., Zhang, M., Ji, M. et al. The neuroprotective mechanism of lithium after ischaemic stroke. Commun Biol 5, 105 (2022). https://doi.org/10.1038/s42003-022-03051-2 [BioGems 제품이나 PeproTech 으로 표기].
- Matsuzaki S, Eyster C, Newhardt MF, Giorgione JR, Kinter C, Young ZT, Kinter M, Humphries KM. Insulin signaling alters antioxidant capacity in the diabetic heart. Redox Biol. 2021 Nov;47:102140. doi: 10.1016/j.redox.2021.102140. Epub 2021 Sep 20. PMID: 34560411; PMCID: PMC8473541.
- Leyria J, Orchard I, Lange AB. The involvement of insulin/ToR signaling pathway in reproductive performance of Rhodnius prolixus. Insect Biochem Mol Biol. 2021 Mar;130:103526. doi: 10.1016/j.ibmb.2021.103526. Epub 2021 Jan 13. PMID: 33453353.
- Esnault S, Leet JP, Johansson MW, Barretto KT, Fichtinger PS, Fogerty FJ, Bernau K, Mathur SK, Mosher DF, Sandbo N, Jarjour NN. Eosinophil cytolysis on Immunoglobulin G is associated with microtubule formation and suppression of rho-associated protein kinase signalling. Clin Exp Allergy. 2020 Feb;50(2):198-212. doi: 10.1111/cea.13538. Epub 2019 Dec 9. PMID: 31750580; PMCID: PMC6994386.
ADDITIONAL INFORMATION
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Applications:
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FA
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Synonyms:
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, LY-294002
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Formulation:
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Crystalline solid
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Chemical Name:
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2-morpholin-4-yl-8-phenylchromen-4-one
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Molecular Formula:
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C19H17NO3 |
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Molecular Weight:
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307.3
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CAS Number
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154447-36-6
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Gharbi, S., Zvelebil, M., Shuttleworth, S., Hancox, T., Saghir, N., Timms, J., & Waterfield, M. (2007). Exploring the specificity of the PI3K family inhibitor LY294002. Biochem. J, 404, 15-21. Vlahos, C. J., Matter, W. F., Hui, K. Y., & Brown, R. F. (1994). A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). Journal of Biological Chemistry, 269(7), 5241-5248. Sanchezmargalet, V., Goldfine, I. D., Vlahos, C. J., & Sung, C. K. (1994). Role of phosphatidylinositol-3-kinase in insulin receptor signaling: studies with inhibitor, LY294002. Biochemical and biophysical research communications,204(2), 446-452 |
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