CHIR99021-10mg

CHIR 99021

CHIR 99021

CHIR 99021은 aminopyrimidine 유도체로써, glycogen synthase kinase 3 (GSK-3)의 선택적이고 강력한 억제제 입니다. 인간 및 마우스 줄기세포주 유지에 사용되며, 다른 시약과 함께 체세포를 줄기세포로 화학적으로 재프로그래밍하는 데 사용됩니다.

카테고리: , , 태그: , , , ,

CHIR 99021

CHIR 99021은 aminopyrimidine 유도체로써, glycogen synthase kinase 3 (GSK-3)의 선택적이고 강력한 억제제 입니다.

인간 및 마우스 줄기세포주 유지에 사용되며, 다른 시약과 함께 화학적으로 체세포를 줄기세포로 재프로그래밍하는 데 사용됩니다.

Catalog Number : 2520691
SIZE 가격 (부가세별도) 제품번호
1mg
$40.00
2520691-1mg
10mg
$160.00
2520691-10mg
  • Preparation & Storage : Soluble in organic solvents such as DMSO . DMSO up to 2.5 mg/ml  (  5.3724  mM ). Product should be kept at -20°C.
  • Download TDS

 

[제품 인용 최신 논문]
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  13. Detraux D, Caruso M, Feller L, Fransolet M, Meurant S, Mathieu J, Arnould T, Renard P. A critical role for heme synthesis and succinate in the regulation of pluripotent states transitions. Elife. 2023 Jul 10;12:e78546. doi: 10.7554/eLife.78546. PMID: 37428012; PMCID: PMC10425175.
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  17. Perréard M, Florent R, Divoux J, Grellard JM, Lequesne J, Briand M, Clarisse B, Rousseau N, Lebreton E, Dubois B, Harter V, Lasne-Cardon A, Drouet J, Johnson A, Le Page AL, Bazille C, Jeanne C, Figeac M, Goardon N, Vaur D, Micault E, Humbert M, Thariat J, Babin E, Poulain L, Weiswald LB, Bastit V. ORGAVADS: establishment of tumor organoids from head and neck squamous cell carcinoma to assess their response to innovative therapies. BMC Cancer. 2023 Mar 9;23(1):223. doi: 10.1186/s12885-023-10692-x. PMID: 36894916; PMCID: PMC9999487.
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  19. Welby E, Ebert AD. Diminished motor neuron activity driven by abnormal astrocytic EAAT1 glutamate transporter activity in spinal muscular atrophy is not fully restored after lentiviral SMN delivery. Glia. 2023 May;71(5):1311-1332. doi: 10.1002/glia.24340. Epub 2023 Jan 18. PMID: 36655314.
  20. Luo Q, Pui HP, Chen J, Yu L, Jannig PR, Pei Y, Zhao L, Chen X, Petropoulos S, Ruas JL, Wu J, Deng Q. Epiblast-like stem cells established by Wnt/β-catenin signaling manifest distinct features of formative pluripotency and germline competence. Cell Rep. 2023 Jan 31;42(1):112021. doi: 10.1016/j.celrep.2023.112021. Epub 2023 Jan 23. PMID: 36848234; PMCID: PMC10026833.
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  23. Ho DLL, Lee S, Du J, Weiss JD, Tam T, Sinha S, Klinger D, Devine S, Hamfeldt A, Leng HT, Herrmann JE, He M, Fradkin LG, Tan TK, Standish D, Tomasello P, Traul D, Dianat N, Ladi R, Vicard Q, Katikireddy K, Skylar-Scott MA. Large-Scale Production of Wholly Cellular Bioinks via the Optimization of Human Induced Pluripotent Stem Cell Aggregate Culture in Automated Bioreactors. Adv Healthc Mater. 2022 Dec;11(24):e2201138. doi: 10.1002/adhm.202201138. Epub 2022 Nov 22. PMID: 36314397; PMCID: PMC10234214.
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  27. [IF 14] Skylar-Scott MA, Uzel SGM, Nam LL, Ahrens JH, Truby RL, Damaraju S, Lewis JA. Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channels. Sci Adv. 2019 Sep 6;5(9):eaaw2459. doi: 10.1126/sciadv.aaw2459. PMID: 31523707; PMCID: PMC6731072.
  28. Napiwocki, B. N., Stempien, A., Lang, D., Kruepke, R. A., Kim, G., Zhang, J., Eckhardt, L. L., Glukhov, A. V., Kamp, T. J., & Crone, W. C. (2021). Micropattern platform promotes extracellular matrix remodeling by human PSC-derived cardiac fibroblasts and enhances contractility of co-cultured cardiomyocytes. Physiological Reports, 9, e15045. https://doi.org/10.14814/phy2.15045.

 

Catalog Number : 2520691
product image

ADDITIONAL INFORMATION

Applications:
FA
Synonyms:
Chir99021, CHEMBL412142, GSK-3 Inhibitor XVI, AGN-PC-0MWAEX
Formulation:
Crystalline solid
Chemical Name:
6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile
Molecular Formula:

C22H18Cl2N8
Molecular Weight:
465.3
CAS Number
252917-06-9
Purity:
≥95%
Storage Conditions:
Product should be kept at -20°C.
References:

Li, W., Wei, W., Zhu, S., Zhu, J., Shi, Y., Lin, T., … & Ding, S. (2009). Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell stem cell, 4(1), 16-19.

Ye, S., Tan, L., Yang, R., Fang, B., Qu, S., Schulze, E. N., … & Li, P. (2012). Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PloS one,7(4), e35892.

Wu, Y., Ai, Z., Yao, K., Cao, L., Du, J., Shi, X., … & Zhang, Y. (2013). CHIR99021 promotes self-renewal of mouse embryonic stem cells by modulation of protein-encoding gene and long intergenic non-coding RNA expression. Experimental cell research, 319(17), 2684-2699.

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